Nooance Copper Peptide Serum 2% Versus Medik8 Liquid Peptides

Nooance Copper Peptide Serum 2% Versus Medik8 Liquid Peptides

This anti-aging serum is formulated around Copper Tripeptide-1 to soften the look of wrinkles and strengthen the skin barrier.

This anti-aging serum is formulated around Carnosine and Palmitoyl Tripeptide-5 to soften the look of wrinkles and refine skin texture.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Glycerin

Pentylene Glycol

Methylpropanediol

1,2-Hexanediol

Panthenol

Alpha-Glucan Oligosaccharide

Bis(Tripeptide-1) Copper Acetate

Copper Tripeptide-1

Sodium Hyaluronate

Myristoyl Nonapeptide-3

Acetyl Tetrapeptide-2

N-Prolyl Palmitoyl Tripeptide-56 Acetate

Trifluoroacetyl Tripeptide-2

Palmitoyl Tetrapeptide-50

Tripeptide-1

Heptapeptide-15 Palmitate

Copper Palmitoyl Heptapeptide-14

Hydrolyzed Beta-Glucan

Sodium Carboxymethyl Beta-Glucan

Butylene Glycol

Citric Acid

Caprylyl Glycol

Sodium Benzoate

Potassium Sorbate

Dextran

Lactic Acid/Glycolic Acid Copolymer

Polyvinyl Alcohol

Sodium Hydroxide

Water, Glycerin, Pentylene Glycol, Methylpropanediol, 1,2-Hexanediol, Panthenol, Alpha-Glucan Oligosaccharide, Bis(Tripeptide-1) Copper Acetate, Copper Tripeptide-1, Sodium Hyaluronate, Myristoyl Nonapeptide-3, Acetyl Tetrapeptide-2, N-Prolyl Palmitoyl Tripeptide-56 Acetate, Trifluoroacetyl Tripeptide-2, Palmitoyl Tetrapeptide-50, Tripeptide-1, Heptapeptide-15 Palmitate, Copper Palmitoyl Heptapeptide-14, Hydrolyzed Beta-Glucan, Sodium Carboxymethyl Beta-Glucan, Butylene Glycol, Citric Acid, Caprylyl Glycol, Sodium Benzoate, Potassium Sorbate, Dextran, Lactic Acid/Glycolic Acid Copolymer, Polyvinyl Alcohol, Sodium Hydroxide

Inulin

Carnosine

Carbomer

Polysorbate 20

Phenoxyethanol

Hydroxypropyl Cyclodextrin

Dunaliella Salina Extract

Ethylhexylglycerin

Palmitoyl Tripeptide-5

Acetyl Hexapeptide-8

Tetrapeptide-21

Pentapeptide-18

Palmitoyl Tripeptide-1

Pantolactone

Palmitoyl Tripeptide-38

Palmitoyl Tetrapeptide-7

Glyceryl Caprylate

Phenylpropanol

Xanthan Gum

Water, Glycerin, Butylene Glycol, Inulin, Sodium Hyaluronate, Panthenol, Alpha-Glucan Oligosaccharide, Carnosine, Carbomer, Polysorbate 20, Caprylyl Glycol, Phenoxyethanol, Hydroxypropyl Cyclodextrin, Dunaliella Salina Extract, Ethylhexylglycerin, Citric Acid, Palmitoyl Tripeptide-5, Sodium Benzoate, Acetyl Hexapeptide-8, Tetrapeptide-21, Pentapeptide-18, Palmitoyl Tripeptide-1, Pantolactone, Palmitoyl Tripeptide-38, Palmitoyl Tetrapeptide-7, Glyceryl Caprylate, Lactic Acid/Glycolic Acid Copolymer, Polyvinyl Alcohol, Phenylpropanol, Copper Palmitoyl Heptapeptide-14, Heptapeptide-15 Palmitate, Potassium Sorbate, Xanthan Gum

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Alpha-Glucan Oligosaccharide is a prebiotic. It prevents harmful bacteria from growing on skin by keeping the skin's microbiome in balance.

Another benefit of this ingredient is its antioxidant properties. Antioxidants protect our skin from oxidative damage.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.

Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.

Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).

Citric Acid is an alpha hydroxy acid (AHA) naturally found in citrus fruits like oranges, lemons, and limes.

Like other AHAs, citric acid can exfoliate skin by breaking down the bonds that hold dead skin cells together. This helps reveal smoother and brighter skin underneath.

However, this exfoliating effect only happens at high concentrations (20%) which can be hard to find in cosmetic products.

Due to this, citric acid is usually included in small amounts as a pH adjuster. This helps keep products slightly more acidic and compatible with skin's natural pH.

In skincare formulas, citric acid can:

While it can provide some skin benefits, research shows lactic acid and glycolic acid are generally more effective and less irritating exfoliants.

Most citric acid used in skincare today is made by fermenting sugars (usually from molasses). This synthetic version is identical to the natural citrus form but easier to stabilize and use in formulations.

Rosacea skin has a lower threshold for acids generally, with 62.5% of rosacea subjects in one study reacting to lactic acid in a sting test. This is why we mark citric acid as a potential rosacea trigger.

However, this ingredient shows up as a pH adjuster or chelator at roughly 0.1-1% in many products. These low levels are unlikely to be an issue for rosacea skin and becomes a potential trigger at exfoliating concentrations (20%). Because everybody's skin is unique, we recommend a patch test if you are unsure.

This peptide is the copper salt and formed by reacting palmitic acid and heptapeptide-14.

This uses a high-tech delivery system called The Cosmetic Drone, where the peptide is enclosed in a shell made from Lactic Acid/Glycolic Acid Copolymer and Polyvinyl Alcohol. Another peptide on the outside guides the capsule to fibroblast cells, the collagen-producing cells in the skin.

Once it reaches the fibroblasts, Copper Palmitoyl Heptapeptide-14 boosts the production of collagen and elastin.

This advanced system works at an incredibly low concentration of just 0.001%.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Heptapeptide-15 Palmitate is a synthetic targeting peptide. It's made up of seven amino acids with a palmitic acid tail attached.

This fatty acid attachment increases the molecule's hydrophobicity, improves stability, reduces enzyme degradation, and enhances its ability to cross the skin's lipid barrier (this is a common challenge for peptides).

As a targeting peptide, it sits on the outer shell of an encapsulated ingredient system and seeks out receptors on collagen and elastin producing cells in skin.

Once it binds, the cell internalizes the capsule and releases the active payload inside; it essentially acts as a GPS guiding ingredients to the right place.

It also mimicks the skin's natural growth factors to support skin firmness by upping production of collagen, elastin, glycosaminoglycans (GAGs).

Most of the evidence for this ingredient comes from manufacturer in vitro data, so independent clinical trials are still limited. However, the underlying mechanism is well-supported by the broader cosmetic peptide literature.

Fungal acne note: Usually a palmitic acid component can feed Malassezia in unbound form, but here is is covalently bonded to the peptide. This means it is very difficult for Malassezia to access, and therefore very unlikely to cause fungal acne.

This ingredient is a combination of two AHAs, lactic acid and glycolic acid. It has exfoliating properties

Panthenol is a common ingredient that helps hydrate and soothe the skin. It is found naturally in our skin and hair.

There are two forms of panthenol: D and L.

D-panthenol is also known as dexpanthenol. Most cosmetics use dexpanthenol or a mixture of D and L-panthenol.

Panthenol is famous due to its ability to go deeper into the skin's layers. Using this ingredient has numerous pros (and no cons):

Like hyaluronic acid, panthenol is a humectant. Humectants are able to bind and hold large amounts of water to keep skin hydrated.

This ingredient works well for wound healing. It works by increasing tissue in the wound and helps close open wounds.

Once oxidized, panthenol converts to pantothenic acid. Panthothenic acid is found in all living cells.

This ingredient is also referred to as pro-vitamin B5.

We don't have a description for Polyvinyl Alcohol yet.

Potassium Sorbate is a preservative used to prevent yeast and mold in products. It is commonly found in both cosmetic and food products.

This ingredient comes from potassium salt derived from sorbic acid. Sorbic acid is a natural antibiotic and effective against fungus.

Both potassium sorbate and sorbic acid can be found in baked goods, cheeses, dried meats, dried fruit, ice cream, pickles, wine, yogurt, and more.

You'll often find this ingredient used with other preservatives.

Sodium Benzoate is a preservative. It's used in both cosmetic and food products to inhibit the growth of mold and bacteria. It is typically produced synthetically.

Both the US FDA and EU Health Committee have approved the use of sodium benzoate. In the US, levels of 0.1% (of the total product) are allowed.

Sodium benzoate works as a preservative by inhibiting the growth of bacteria inside of cells. It prevents the cell from fermenting a type of sugar using an enzyme called phosphofructokinase.

It is the salt of benzoic acid. Foods containing sodium benzoate include soda, salad dressings, condiments, fruit juices, wines, and snack foods.

Studies for using ascorbic acid and sodium benzoate in cosmetics are lacking, especially in skincare routines with multiple steps.

We always recommend speaking with a professional, such as a dermatologist, if you have any concerns.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Similar Comparisons