Numbuzin 9+ NAD Bio Lifting-Sil Essence Versus SkinCeuticals P-Tiox Wrinkle Modulating Peptide Serum

Numbuzin 9+ NAD Bio Lifting-Sil Essence Versus SkinCeuticals P-Tiox Wrinkle Modulating Peptide Serum

This anti-aging essence is formulated around Niacinamide and Adenosine to soften the look of wrinkles and refine skin texture.

This anti-aging serum is formulated around Dipeptide Diaminobutyroyl Benzylamide Diacetate and Acetyl Hexapeptide-8 to soften the look of wrinkles and refine skin texture.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Glycerin

Hydrogenated Poly(C6-14 Olefin)

Polyglycerin-3

Butylene Glycol

Pentaerythrityl Tetraethylhexanoate

Propanediol

Dimethicone

1,2-Hexanediol

Niacinamide

Methylpropanediol

Cetearyl Alcohol

Glyceryl Stearate

Hydrogenated Vegetable Oil

Polyglyceryl-3 Methylglucose Distearate

Butyrospermum Parkii Butter

Dimethicone Crosspolymer

Ammonium Acryloyldimethyltaurate/Vp Copolymer

Sodium Polyacrylate

Hydrogenated Lecithin

Carbomer

Xanthan Gum

Pentylene Glycol

Tromethamine

Ethylhexylglycerin

Adenosine

Palmitic Acid

Stearic Acid

Sodium Phytate

Cholesterol

Sodium Hyaluronate

Adenosine Triphosphate

Hydroxypropyl Cyclodextrin

Nicotinamide Adenine Dinucleotide

Beta-Glucan

Tocopherol

Palmitoyl Tripeptide-5

Copper Gluconate

Saccharomyces/Copper Ferment

Saccharomyces/Iron Ferment

Saccharomyces/Magnesium Ferment

Saccharomyces/Silicon Ferment

Saccharomyces/Zinc Ferment

Capryloyl Dipeptide-17

Thioctic Acid

Leuconostoc/Radish Root Ferment Filtrate

Glutathione

Tremella Fuciformis Extract

Haematococcus Pluvialis Oil

Potassium Hydroxide

Resveratrol

Hesperidin Methyl Chalcone

Sorbitan Laurate

Steareth-20

Astaxanthin

Sodium Lactate

Hydroxyethylcellulose

Acetyl Dipeptide-1 Cetyl Ester

Dipeptide Diaminobutyroyl Benzylamide Diacetate

Heptasodium Hexacarboxymethyl Dipeptide-12

Panthenol

Polysorbate 20

Sodium Citrate

Chlorhexidine Digluconate

Dextran

Hexapeptide-2

Magnesium Chloride

Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate

Acetyl Tetrapeptide-5

Dipeptide-2

Potassium Sorbate

Acetyl Hexapeptide-8

Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine

Citric Acid

Biotin

Palmitoyl Tetrapeptide-7

Biotinoyl Tripeptide-1

Acetyl Tetrapeptide-3

Trifolium Pratense Flower Extract

Tocopheryl Acetate

Palmitoyl Tripeptide-8

Dipeptide-4

Hexapeptide-11

Pentapeptide-18

Tripeptide-3

Sh-Decapeptide-7

Sh-Octapeptide-4

Palmitoyl Tripeptide-1

Ascorbic Acid Polypeptide

Hexapeptide-9

Oligopeptide-3

Palmitoyl Hexapeptide-12

Tripeptide-1

Palmitoyl Pentapeptide-4

Ubiquinone

Copper Tripeptide-1

Caffeoyl Tripeptide-1

Caffeoyl Sh-Octapeptide-4

Galloyl Pentapeptide-33

Kojyl Carboxy Dipeptide-23

Nicotinoyl Tripeptide-1

Octapeptide-7

Oligopeptide-1

Sh-Decapeptide-9

Sh-Oligopeptide-9

Sh-Pentapeptide-19

Asparagine

Glutamine

Tryptophan

Oligopeptide-2

Sh-Oligopeptide-1

Sh-Oligopeptide-2

Sh-Polypeptide-1

Sh-Polypeptide-22

Sh-Polypeptide-3

Acetyl Octapeptide-3

Acetyl Tetrapeptide-2

Acetyl Tetrapeptide-9

Carnosine

Nonapeptide-1

Water, Glycerin, Hydrogenated Poly(C6-14 Olefin), Polyglycerin-3, Butylene Glycol, Pentaerythrityl Tetraethylhexanoate, Propanediol, Dimethicone, 1,2-Hexanediol, Niacinamide, Methylpropanediol, Cetearyl Alcohol, Glyceryl Stearate, Hydrogenated Vegetable Oil, Polyglyceryl-3 Methylglucose Distearate, Butyrospermum Parkii Butter, Dimethicone Crosspolymer, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Sodium Polyacrylate, Hydrogenated Lecithin, Carbomer, Xanthan Gum, Pentylene Glycol, Tromethamine, Ethylhexylglycerin, Adenosine, Palmitic Acid, Stearic Acid, Sodium Phytate, Cholesterol, Sodium Hyaluronate, Adenosine Triphosphate, Hydroxypropyl Cyclodextrin, Nicotinamide Adenine Dinucleotide, Beta-Glucan, Tocopherol, Palmitoyl Tripeptide-5, Copper Gluconate, Saccharomyces/Copper Ferment, Saccharomyces/Iron Ferment, Saccharomyces/Magnesium Ferment, Saccharomyces/Silicon Ferment, Saccharomyces/Zinc Ferment, Capryloyl Dipeptide-17, Thioctic Acid, Leuconostoc/Radish Root Ferment Filtrate, Glutathione, Tremella Fuciformis Extract, Haematococcus Pluvialis Oil, Potassium Hydroxide, Resveratrol, Hesperidin Methyl Chalcone, Sorbitan Laurate, Steareth-20, Astaxanthin, Sodium Lactate, Hydroxyethylcellulose, Acetyl Dipeptide-1 Cetyl Ester, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Heptasodium Hexacarboxymethyl Dipeptide-12, Panthenol, Polysorbate 20, Sodium Citrate, Chlorhexidine Digluconate, Dextran, Hexapeptide-2, Magnesium Chloride, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Acetyl Tetrapeptide-5, Dipeptide-2, Potassium Sorbate, Acetyl Hexapeptide-8, Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine, Citric Acid, Biotin, Palmitoyl Tetrapeptide-7, Biotinoyl Tripeptide-1, Acetyl Tetrapeptide-3, Trifolium Pratense Flower Extract, Tocopheryl Acetate, Palmitoyl Tripeptide-8, Dipeptide-4, Hexapeptide-11, Pentapeptide-18, Tripeptide-3, Sh-Decapeptide-7, Sh-Octapeptide-4, Palmitoyl Tripeptide-1, Ascorbic Acid Polypeptide, Hexapeptide-9, Oligopeptide-3, Palmitoyl Hexapeptide-12, Tripeptide-1, Palmitoyl Pentapeptide-4, Ubiquinone, Copper Tripeptide-1, Caffeoyl Tripeptide-1, Caffeoyl Sh-Octapeptide-4, Galloyl Pentapeptide-33, Kojyl Carboxy Dipeptide-23, Nicotinoyl Tripeptide-1, Octapeptide-7, Oligopeptide-1, Sh-Decapeptide-9, Sh-Oligopeptide-9, Sh-Pentapeptide-19, Asparagine, Glutamine, Tryptophan, Oligopeptide-2, Sh-Oligopeptide-1, Sh-Oligopeptide-2, Sh-Polypeptide-1, Sh-Polypeptide-22, Sh-Polypeptide-3, Acetyl Octapeptide-3, Acetyl Tetrapeptide-2, Acetyl Tetrapeptide-9, Carnosine, Nonapeptide-1

Gluconolactone

PEG/PPG/Polybutylene Glycol-8/5/3 Glycerin

Alcohol Denat.

Methyl Gluceth-20

Salicylic Acid

Chlorphenesin

Phytic Acid

Sodium Benzoate

Laminaria Digitata Extract

Water, Niacinamide, Gluconolactone, Butylene Glycol, PEG/PPG/Polybutylene Glycol-8/5/3 Glycerin, Alcohol Denat., Pentylene Glycol, Methyl Gluceth-20, Glycerin, Potassium Hydroxide, Hydroxyethylcellulose, Salicylic Acid, Chlorphenesin, Phytic Acid, Adenosine, Sodium Benzoate, Laminaria Digitata Extract, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Acetyl Hexapeptide-8

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Acetyl Hexapeptide-8 (also known as Argireline) is a synthetic hexapeptide that is often called a "topical Botox alternative".

It works by mimicking how Botox relaxes muscles; it interferes with the signaling process that tells your facial muscles to contract. This can help soften expression lines like forehead wrinkles or crow's feet over time.

The comparison to Botox does have limits because the molecule is water-loving and relatively large.

Acetyl Hexapeptide-8 has a hard time absorbing deeply enough through the skin's outer barrier to actually reach the muscles.

So whether it truly works the way Botox does at a biological level is still up for debate, but early clinical outcomes are fairly encouraging.

A 12 week human study of a multi-ingredient regimen containing this ingredient saw:

While some studies have observed improvements in wrinkle appearance, it is important to note that more consistent results are seen in multi-ingredient formulations (vs just Acetyl Hexapeptide-8 alone).

Some research studies also used higher concentrations (up to 10%) while this ingredient is usually found in concentrations up to 0.005% in leave-on formulations.

Adenosine is a purine nucleoside that your body already makes in every cell. In skincare, it acts mainly as a skin conditioning and anti-aging agent.

The way it works is fairly well mapped out:

Your skin has cells called fibroblasts that build collagen (the stuff that keeps skin firm and smooth). Adenosine basically flips a switch on these cells that tells them to get to work making more collagen and other proteins. These cells slow down on their own as skin ages, so Adenosine helps give them a little nudge to keep going.

The clinical backing is pretty solid too.

A blind, randomized, placebo-controlled trial of 126 women aged 45-65 tested a 0.1% cream twice daily and found real improvements in crow's feet and frown lines using a precise 3D skin-mapping technique; these changes showed up by week 3 and held at 2 months.

A later study using Adenosine-loaded dissolving microneedle patches reported gains in wrinkle depth, dermal density, elasticity, and hydration.

On concentrations, South Korea's Ministry of Food and Drug Safety has set 0.04% as the approved functional anti-wrinkle level. You'll typically see this ingredient used somewhere in the 0.04-0.1% range since it works at low doses.

This ingredient has been found safe for cosmetics with the data showing no irritation or sensitization.

Overall, this is a great ingredient for any anti-aging routine and has no photosensitizing effect, so it suits both AM and PM use.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

This small molecule peptide has similar benefits to Argireline, the "botox" peptide.

According to the manufacturer, this peptide mimics snake venom to freeze muscles. This prevents muscle movement and contractions to prohibit the formation of fine lines and wrinkles.

While this seems promising, research is lacking in proving this ingredient to be as effective as botox.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Hydroxyethylcellulose is used to improve the texture of products. It is created from a chemical reaction involving ethylene oxide and alkali-cellulose. Cellulose is a sugar found in plant cell walls and help give plants structure.

This ingredient helps stabilize products by preventing ingredients from separating. It can also help thicken the texture of a product.

This ingredient can also be found in pill medicines to help our bodies digest other ingredients.

Niacinamide is a multitasking form of vitamin B3 that strengthens the skin barrier, reduces pores and dark spots, regulates oil, and improves signs of aging.

And the best part? It's gentle and well-tolerated by most skin types, including sensitive and reactive skin.

You might have heard of "niacin flush", or the reddening of skin that causes itchiness. Niacinamide has not been found to cause this.

In very rare cases, some individuals may not be able to tolerate niacinamide at all or experience an allergic reaction to it.

If you are experiencing flaking, irritation, and dryness with this ingredient, be sure to double check all your products as this ingredient can be found in all categories of skincare.

When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.

When you apply niacinamide to your skin, your body converts it into nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme that is already found in your cells as "fuel" and powers countless biological processes.

In your skin, NAD helps repair cell damage, produce new healthy cells, support collagen production, strengthen the skin barrier, and fight environmental stressors (like UV and pollution).

Our natural NAD levels start to decline with age, leading to slower skin repair, visible aging, and a weaker skin barrier. By providing your skin niacinamide, you're recharging your skin's NAD levels. This leads to stronger, healthier, and younger looking skin.

Another name for vitamin B3 is nicotinamide. This vitamin is water-soluble and our bodies don't store it. We obtain Vitamin B3 from either food or skincare. Meat, fish, wheat, yeast, and leafy greens contain vitamin B3.

The type of niacinamide used in skincare is synthetically created.

Pentylene Glycol (1,2-pentanediol) is a multitasking little diol with three main roles in a formula:

Research on alkanediols (the family pentylene glycol belongs to) show they work by disrupting microbial cell membranes. This disruption helps the primary preservative system in a product work more effectively at lower doses.

On the safety side, the Cosmetic Ingredient Review Expert Panel has concluded this ingredient to be safe as used in current cosmetic practices + concentrations.

Typical use levels in a formula run about 1-5%.

Potassium Hydroxide (also known as potash) is a strong alkaline ingredient that does one job: it nudges a product's pH up so the whole formula lands in a skin-friendly range.

It's also the base that turns oils into liquid soap during the soap making process.

An expert safety panel reviewed it and found it safe when formulations are made to be non-irritating.

As a pH adjuster, it's typically used well under 1% though regulatory caps go much higher: 5% in nail cuticle removers and 2-4.5% in hair straighteners.

Though there is some concern for irritation from raw or high pH material, a well-balanced formula will be a non-issue for the vast majority of people.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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