Peptide Skincare & BeautySkin science and ingredient guides

Skin science article

Numbuzin No.3 Skin Softening Serum Versus Paula's Choice Regular Strength Daily Skin Clearing Treatment with 2.5% Benzoyl Peroxide

Numbuzin No.3 Skin Softening Serum Versus Paula's Choice Regular Strength Daily Skin Clearing Treatment with 2.5% Benzoyl Peroxide This smoothing serum is formulated around Bifida Ferment Lysate and Galactomyces Ferment Filtrate to refine skin texture and stre

Numbuzin No.3 Skin Softening Serum Versus Paula's Choice Regular Strength Daily Skin Clearing Treatment with 2.5% Benzoyl Peroxide

This smoothing serum is formulated around Bifida Ferment Lysate and Galactomyces Ferment Filtrate to refine skin texture and strengthen the skin barrier.

This acne treatment is formulated around Benzoyl Peroxide and Bisabolol to clear breakouts and calm redness.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Bifida Ferment Lysate

Galactomyces Ferment Filtrate

Butylene Glycol

Methyl Gluceth-20

Water

Niacinamide

PEG-90

1,2-Hexanediol

Glycerin

Squalane

Alteromonas Ferment Extract

Silk Extract

Goat Milk Extract

Sodium Hyaluronate

Panthenol

Adenosine

Glycereth-26

Xanthan Gum

Polyglyceryl-3 Distearate

Glyceryl Stearate Se

Glyceryl Stearate Citrate

Polyglyceryl-3 Methylglucose Distearate

Carbomer

Tromethamine

Caprylyl Glycol

Tropolone

Disodium EDTA

Bifida Ferment Lysate, Galactomyces Ferment Filtrate, Butylene Glycol, Methyl Gluceth-20, Water, Niacinamide, PEG-90, 1,2-Hexanediol, Glycerin, Squalane, Alteromonas Ferment Extract, Silk Extract, Goat Milk Extract, Sodium Hyaluronate, Panthenol, Adenosine, Glycereth-26, Xanthan Gum, Polyglyceryl-3 Distearate, Glyceryl Stearate Se, Glyceryl Stearate Citrate, Polyglyceryl-3 Methylglucose Distearate, Carbomer, Tromethamine, Caprylyl Glycol, Tropolone, Disodium EDTA

Propylene Glycol

Benzoyl Peroxide

Bisabolol

Allantoin

Acrylates/C10-30 Alkyl Acrylate Crosspolymer

Hydroxyethylcellulose

Sodium Citrate

Laureth-4

Sodium Hydroxide

Hexylene Glycol

Phenoxyethanol

Water, Propylene Glycol, Benzoyl Peroxide, Bisabolol, Allantoin, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Hydroxyethylcellulose, Sodium Citrate, Laureth-4, Caprylyl Glycol, Sodium Hydroxide, Disodium EDTA, Hexylene Glycol, Phenoxyethanol

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.

Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.

Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).

Disodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air.

This ingredient mainly works behind the scenes and helps with:

On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it.

One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin).

Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption.

You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Similar Comparisons

The reference edit

Ingredients, questions
& further reading.

Connected source records selected through this article’s public topic index.

01

Formula cabinet

Ingredients & structured notes

Ingredient index

Ingredients Explained

  1. 01These ingredients are found in both products.
  2. 02Ingredients higher up in an ingredient list are typically present in a larger amount.
  3. 03Dimethicone is a type of synthetic silicone created from natural materials such as quartz. It is also known as polydimethylsiloxane.
  4. 04What it does:
  5. 05Dimethicone comes in different viscosities:
  6. 06Depending on the viscosity, dimethicone has different properties.
  7. 07Ingredients lists don't always show which type is used, so we recommend reaching out to the brand if you have questions about the viscosity.
  8. 08This ingredient is unlikely to cause irritation because it does not get absorbed into skin. However, people with silicone allergies should be careful about using this ingredient.
  9. 09Note: Dimethicone may contribute to pilling. This is because it is not oil or water soluble, so pilling may occur when layered with products. When mixed with heavy oils in a formula, the outcome is also quite greasy.
  10. 10Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
  11. 11Topically, glycerin does several things at once:
  12. 12Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
  13. 13Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
  14. 14This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
  15. 15Just know very high concentrations (>40%) can feel tacky in low humidity.
  16. 16Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
  17. 17Glyceryl Stearate is made by reacting glycerin with stearic acid (typically sourced from plant oils like palm or coconut). It's an emulsifier, emollient, and mild occlusive.
  18. 18Emulsifiers help ingredients like oil and water stay mixed so your formula stays nicely blended and uniform in texture.
  19. 19This ingredient is typically used in concentrations between 1-10%. Studies have found it to be non-sensitizing, non-phototoxic, and non-photoallergenic.
  20. 20A close cousin of this ingredient is Glyceryl Stearate SE ("self-emulsifying"). This just has a small amount of sodium or potassium stearate added so it can emulsify without a co-emulsifier.
Source · skinsort.com
02

Product index

Related product references

03

Comparison edit

Read side by side