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Skin science article

Paula's Choice 1% Retinol Treatment Versus Drunk Elephant C-Firma Fresh Day Serum

Paula's Choice 1% Retinol Treatment Versus Drunk Elephant C-Firma Fresh Day Serum This anti-aging treatment is formulated around Retinol and Tetrahexyldecyl Ascorbate to soften the look of wrinkles and refine skin texture. This brightening serum is formulated

Paula's Choice 1% Retinol Treatment Versus Drunk Elephant C-Firma Fresh Day Serum

This anti-aging treatment is formulated around Retinol and Tetrahexyldecyl Ascorbate to soften the look of wrinkles and refine skin texture.

This brightening serum is formulated around Ascorbic Acid and Tocopherol to brighten dull-looking skin and soften the look of wrinkles.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Dimethicone

Glycerin

Butylene Glycol

Isononyl Isononanoate

Castor Isostearate Succinate

Glyceryl Stearate

C12-15 Alkyl Benzoate

Dimethicone Crosspolymer

PEG-33

Polysorbate 20

Behenyl Alcohol

PEG-100 Stearate

Pentaerythrityl Tetraisostearate

Polymethylsilsesquioxane

Tetrahexyldecyl Ascorbate

Retinol

Ceramide Ng

Palmitoyl Tetrapeptide-7

Palmitoyl Hexapeptide-12

Sodium Hyaluronate

Dipotassium Glycyrrhizate

Glycyrrhiza Glabra Root Extract

Avena Sativa Kernel Extract

Arctium Lappa Seed Oil

Salix Alba Extract

Glycine Soja Sterols

Lecithin

Allantoin

Tocopheryl Acetate

Hydrolyzed Soy Protein

Sorbitan Laurate

Acetyl Dipeptide-1 Cetyl Ester

Disodium EDTA

Hydroxyethylcellulose

Palmitoyl Tripeptide-1

Sodium Hydroxide

Tribehenin

Caprylyl Glycol

Ethylhexylglycerin

Pentylene Glycol

PEG-75 Shea Butter Glycerides

PPG-12/Smdi Copolymer

PEG-10 Phytosterol

PEG-8 Dimethicone

PEG-14

Magnesium Aluminum Silicate

Arachidyl Glucoside

Arachidyl Alcohol

Sclerotium Gum

Carbomer

Phenoxyethanol

Benzoic Acid

Water, Dimethicone, Glycerin, Butylene Glycol, Isononyl Isononanoate, Castor Isostearate Succinate, Glyceryl Stearate, C12-15 Alkyl Benzoate, Dimethicone Crosspolymer, PEG-33, Polysorbate 20, Behenyl Alcohol, PEG-100 Stearate, Pentaerythrityl Tetraisostearate, Polymethylsilsesquioxane, Tetrahexyldecyl Ascorbate, Retinol, Ceramide Ng, Palmitoyl Tetrapeptide-7, Palmitoyl Hexapeptide-12, Sodium Hyaluronate, Dipotassium Glycyrrhizate, Glycyrrhiza Glabra Root Extract, Avena Sativa Kernel Extract, Arctium Lappa Seed Oil, Salix Alba Extract, Glycine Soja Sterols, Lecithin, Allantoin, Tocopheryl Acetate, Hydrolyzed Soy Protein, Sorbitan Laurate, Acetyl Dipeptide-1 Cetyl Ester, Disodium EDTA, Hydroxyethylcellulose, Palmitoyl Tripeptide-1, Sodium Hydroxide, Tribehenin, Caprylyl Glycol, Ethylhexylglycerin, Pentylene Glycol, PEG-75 Shea Butter Glycerides, PPG-12/Smdi Copolymer, PEG-10 Phytosterol, PEG-8 Dimethicone, PEG-14, Magnesium Aluminum Silicate, Arachidyl Glucoside, Arachidyl Alcohol, Sclerotium Gum, Carbomer, Phenoxyethanol, Benzoic Acid

Dimethyl Isosorbide

Ascorbic Acid

Laureth-23

Tocopherol

Lactobacillus/Pumpkin Ferment Extract

Sclerocarya Birrea Seed Oil

Vitis Vinifera Juice Extract

Ferulic Acid

Phyllanthus Emblica Fruit Extract

Camellia Sinensis Leaf Extract

Lactobacillus/Punica Granatum Fruit Ferment Extract

Propanediol

Gluconolactone

Sodium Hyaluronate Crosspolymer

Oryza Sativa Bran Extract

Glutamylamidoethyl Imidazole

Tetrahydrobisdemethoxydiferuloylmethane

Tetrahydrodemethoxydiferuloylmethane

Tetrahydrodiferuloylmethane

Caprylhydroxamic Acid

Leuconostoc/Radish Root Ferment Filtrate

Sorbic Acid

Sodium Benzoate

Chondrus Crispus Extract

Water, Dimethyl Isosorbide, Ascorbic Acid, Laureth-23, Glycerin, Tocopherol, Lactobacillus/Pumpkin Ferment Extract, Sclerocarya Birrea Seed Oil, Dipotassium Glycyrrhizate, Glycyrrhiza Glabra Root Extract, Vitis Vinifera Juice Extract, Ferulic Acid, Phyllanthus Emblica Fruit Extract, Camellia Sinensis Leaf Extract, Lactobacillus/Punica Granatum Fruit Ferment Extract, Propanediol, Gluconolactone, Sodium Hyaluronate Crosspolymer, Sodium Hyaluronate, Oryza Sativa Bran Extract, Glutamylamidoethyl Imidazole, Tetrahydrobisdemethoxydiferuloylmethane, Tetrahydrodemethoxydiferuloylmethane, Tetrahydrodiferuloylmethane, Pentylene Glycol, Caprylhydroxamic Acid, Leuconostoc/Radish Root Ferment Filtrate, Sorbic Acid, Phenoxyethanol, Sodium Benzoate, Caprylyl Glycol, Chondrus Crispus Extract, Ethylhexylglycerin

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.

Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.

Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).

Dipotassium Glycyrrhizate comes from licorice root.

Extracts of licorice have demonstrated to have antibacterial, anti‐inflammatory, antiviral, antioxidant properties.

One component, glabridin, has extra potent antioxidant and soothing properties. It has also been found to block pigmentation from UVB rays in guinea pigs.

Licorice Root also contains a flavonoid. Flavonoids are a natural substance from in plants. Flavonoids also have antioxidant properties.

Another component, glycyrrhizin, has been found to have anti-inflammatory and antimicrobial benefits. This may make licorice root extract effective at treating acne. However, more research is needed to support this.

Liquiritin is one of the flavone compounds found in licorice. It has been found to help lighten skin by preventing tyrosinase from reacting with tyrosine. When the two react, protein is converted to melanin. Melanin is the substance in your body that gives your features pigmentation.

Licorice root is native to Southern Europe and Asia. It has been used in traditional Chinese medicine to help with respiratory issues.

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Glycyrrhiza Glabra Root Extract is an extract of the roots of Licorice. It has been found to have several benefits such as skin hydrating, conditioning, and soothing.

Pentylene Glycol (1,2-pentanediol) is a multitasking little diol with three main roles in a formula:

Research on alkanediols (the family pentylene glycol belongs to) show they work by disrupting microbial cell membranes. This disruption helps the primary preservative system in a product work more effectively at lower doses.

On the safety side, the Cosmetic Ingredient Review Expert Panel has concluded this ingredient to be safe as used in current cosmetic practices + concentrations.

Typical use levels in a formula run about 1-5%.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Similar Comparisons

The reference edit

Ingredients, questions
& further reading.

Connected source records selected through this article’s public topic index.

01

Formula cabinet

Ingredients & structured notes

Ingredient index

Ingredients Explained

  1. 01These ingredients are found in both products.
  2. 02Ingredients higher up in an ingredient list are typically present in a larger amount.
  3. 03Also known as Avobenzone, this ingredient is an oil-soluble used to absorb the full spectrum of UVA rays (peak 357 nm).
  4. 04It's one of the most effective UVA filters available but has a major caveat of photostability: avobenzone is susceptible to photodegradation.
  5. 05This means it can lose efficacy when exposed to sunlight without the help of a stabilizing agent.
  6. 06Studies show antioxidants (like vitamin E or vitamin C) and some UV filters (like octocrylene and Tinosorb S) can meaningfully improve its stability in a formulation.
  7. 07The maximum allowable concentration according to regulation is 3% in the US + Canada, and 5% in the EU, Australia, China, Korea, and ASEAN countries.
  8. 08It has a well-support safety profile: a comprehensive 2025 review found minimal toxicity with no evidence of carcinogenicity.
  9. 09Overall, avobenzone is a safe and regulated ingredient used in sunscreen for over 40 years.
  10. 10Dimethicone is a type of synthetic silicone created from natural materials such as quartz. It is also known as polydimethylsiloxane.
  11. 11What it does:
  12. 12Dimethicone comes in different viscosities:
  13. 13Depending on the viscosity, dimethicone has different properties.
  14. 14Ingredients lists don't always show which type is used, so we recommend reaching out to the brand if you have questions about the viscosity.
  15. 15This ingredient is unlikely to cause irritation because it does not get absorbed into skin. However, people with silicone allergies should be careful about using this ingredient.
  16. 16Note: Dimethicone may contribute to pilling. This is because it is not oil or water soluble, so pilling may occur when layered with products. When mixed with heavy oils in a formula, the outcome is also quite greasy.
  17. 17Disodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air.
  18. 18This ingredient mainly works behind the scenes and helps with:
  19. 19On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it.
  20. 20One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too st…
Source · skinsort.com
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Product index

Related product references

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Comparison edit

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