Skin science article
Paula's Choice C5 Super Boost Moisturizer Versus Kiehl's Ultra Facial Moisturizer
Paula's Choice C5 Super Boost Moisturizer Versus Kiehl's Ultra Facial Moisturizer This brightening moisturizer is formulated around 3-O-Ethyl Ascorbic Acid and Ascorbyl Glucoside to brighten dull-looking skin. This day moisturizer is formulated around Squalene
Paula's Choice C5 Super Boost Moisturizer Versus Kiehl's Ultra Facial Moisturizer
This brightening moisturizer is formulated around 3-O-Ethyl Ascorbic Acid and Ascorbyl Glucoside to brighten dull-looking skin.
This day moisturizer is formulated around Squalene to hydrate skin.
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Dicaprylyl Carbonate
3-O-Ethyl Ascorbic Acid
Dimethicone
Butylene Glycol
Polyglyceryl-6 Distearate
Ascorbyl Glucoside
Squalane
Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer
Acetyl Sh-Hexapeptide-5 Amide Acetate
Citrullus Lanatus Seed Oil
Hydrogenated Lecithin
Theobroma Cacao Seed Butter
Hydrogenated Phosphatidylcholine
Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate
Sodium Hyaluronate
Oryza Sativa Bran Extract
Propanediol
Jojoba Esters
Tocopherol
Acetyl Zingerone
Cetyl Palmitate
Caprylyl Glycol
Cetyl Alcohol
Polyglyceryl-3 Beeswax
Sodium Hydroxide
Sorbitan Olivate
Sorbitan Palmitate
Helianthus Annuus Extract
Ethylhexylglycerin
Hexylene Glycol
Sodium Phytate
Polysorbate 60
Sorbitan Isostearate
Lecithin
Rosmarinus Officinalis Leaf Extract
Glycine Soja Oil
Lysolecithin
Bacillus Ferment
Citric Acid
Polyglutamic Acid
Beta-Sitosterol
Phytic Acid
Squalene
Phenoxyethanol
Sodium Benzoate
Potassium Sorbate
Water, Dicaprylyl Carbonate, 3-O-Ethyl Ascorbic Acid, Dimethicone, Butylene Glycol, Polyglyceryl-6 Distearate, Ascorbyl Glucoside, Squalane, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Acetyl Sh-Hexapeptide-5 Amide Acetate, Citrullus Lanatus Seed Oil, Hydrogenated Lecithin, Theobroma Cacao Seed Butter, Hydrogenated Phosphatidylcholine, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, Sodium Hyaluronate, Oryza Sativa Bran Extract, Propanediol, Jojoba Esters, Tocopherol, Acetyl Zingerone, Cetyl Palmitate, Caprylyl Glycol, Cetyl Alcohol, Polyglyceryl-3 Beeswax, Sodium Hydroxide, Sorbitan Olivate, Sorbitan Palmitate, Helianthus Annuus Extract, Ethylhexylglycerin, Hexylene Glycol, Sodium Phytate, Polysorbate 60, Sorbitan Isostearate, Lecithin, Rosmarinus Officinalis Leaf Extract, Glycine Soja Oil, Lysolecithin, Bacillus Ferment, Citric Acid, Polyglutamic Acid, Beta-Sitosterol, Phytic Acid, Squalene, Phenoxyethanol, Sodium Benzoate, Potassium Sorbate
Propylene Glycol
Dicaprylyl Ether
Glycerin
PEG-100 Stearate
Glyceryl Stearate
Hydrogenated Polyisobutene
Sorbitan Oleate
Acrylates/C10-30 Alkyl Acrylate Crosspolymer
Triethanolamine
Beeswax
Disodium EDTA
Stearic Acid
Myristyl Alcohol
Prunus Amygdalus Dulcis Oil
Prunus Armeniaca Kernel Oil
Persea Gratissima Oil
Water, Propylene Glycol, Dicaprylyl Ether, Glycerin, PEG-100 Stearate, Glyceryl Stearate, Squalene, Hydrogenated Polyisobutene, Phenoxyethanol, Sorbitan Oleate, Caprylyl Glycol, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Triethanolamine, Beeswax, Tocopherol, Disodium EDTA, Stearic Acid, Myristyl Alcohol, Prunus Amygdalus Dulcis Oil, Prunus Armeniaca Kernel Oil, Persea Gratissima Oil
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Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.
Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.
Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).
Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).
It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.
On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.
Another perk of this ingredient is that it stays functional across a wide pH range (3-10).
You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.
Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.
Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.
Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.
Squalene is one of the main components of skin surface lipids. It is naturally found in our skin and makes up about 13% of sebum.
Topically, it is an emollient and skin conditioning agent.
Research highlights its role in antioxidant activity, anti-inflammatory effects, skin barrier protection, and wound healing support.
In vivo research has shown that transepidermal water loss (TEWL) caused by irritant exposure can be reverse with squalene supplementation (pointing to barrier recovery support).
Its antioxidant activity is backed by ex vivo and cell-based evidence showing it can scavenge free radicals but large-scale human clinical trials isolating this effect remain limited.
One study found squalene regulated proinflammatory behavior in ways relevant to wound healing, and in vitro fibroblast studies also shows it stimulates cell migration which is a key step in skin repair.
There's just one nuance to know about this ingredient:
Squalene is particularly vulnerable to oxidation; it breaks down from UV exposure 10x faster than the other lipids on your skin's surface. The byproducts of that breakdown can clog pores and trigger inflammation, potentially worsening acne.
This is why squalene is often hydrogenated into its stable counterpart: squalane (with an "a"). Most great formulations will have alreadu kept this in mind.
Squalene has shown no significant clinical evidence of sensitization and is a great hydrating ingredient.
Tocopherol is a fat-soluble antioxidant known as Vitamin E.
You'll find this ingredient in the vast majority of skincare (for good reason). It works to neutralize free radicals, or unstable molecules generated by UV exposure, pollution, and other environmental stressors, before they can cause oxidative damage to your skin cells.
Topically applied tocopherol has been shown to protect against UV damage by ramping up the skin's own natural defense enzymes.
It also acts as a skin conditioning agent; some studies show that regular topical use can improve the skin's water-binding capacity over 2-4 weeks.
This ingredient is especially loved for being a team player. When combined with Vitamin C, the photoprotective effect of both ingredients roughly doubles and the combo also helps reduce UV-induced DNA damage.
This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.
In formulations, it also serves as a stabilizer that helps protect other oxidation-prone ingredients from degrading.
Concentrations usually range from 0.1-1% in most leave-on products.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!