Paula's Choice Clinical Niacinamide 20% Treatment Versus Tula Skincare Sensitive Skin Treatment Drops Calming Vitamin B Serum

Paula's Choice Clinical Niacinamide 20% Treatment Versus Tula Skincare Sensitive Skin Treatment Drops Calming Vitamin B Serum

This pore-care treatment is formulated around Niacinamide and Acetyl Glucosamine to refine the look of pores and refine skin texture.

This calming serum is formulated around Lactococcus Ferment Lysate and Niacinamide to calm redness and strengthen the skin barrier.

What's inside

Key Ingredients

Benefits

Concerns

No concerns

Ingredients Side-by-side

Water

Niacinamide 20%

Pentylene Glycol

Butylene Glycol

Glycerin

Acetyl Glucosamine

Ascorbyl Glucoside

Glycyrrhiza Glabra Root Extract

Spiraea Ulmaria Extract

Portulaca Oleracea Extract

Camellia Japonica Flower Extract

Epigallocatechin Gallate

Boerhavia Diffusa Root Extract

Camellia Sinensis Leaf Extract

Allantoin

Lecithin

Pullulan

Panthenol

Silica

Xanthan Gum

Sclerotium Gum

Propanediol

Sodium Phytate

Phenoxyethanol

Ethylhexylglycerin

Water, Niacinamide 20%, Pentylene Glycol, Butylene Glycol, Glycerin, Acetyl Glucosamine, Ascorbyl Glucoside, Glycyrrhiza Glabra Root Extract, Spiraea Ulmaria Extract, Portulaca Oleracea Extract, Camellia Japonica Flower Extract, Epigallocatechin Gallate, Boerhavia Diffusa Root Extract, Camellia Sinensis Leaf Extract, Allantoin, Lecithin, Pullulan, Panthenol, Silica, Xanthan Gum, Sclerotium Gum, Propanediol, Sodium Phytate, Phenoxyethanol, Ethylhexylglycerin

Lactococcus Ferment Lysate

Polysorbate 20

Niacinamide

Cucumis Sativus Fruit Extract

Beta Vulgaris Root Extract

Daucus Carota Sativa Extract

Avena Sativa Bran Extract

Hydrolyzed Hemp Seed Protein

Aloe Barbadensis Leaf Extract

Zingiber Officinale Root Extract

Sodium Hyaluronate

Fructooligosaccharides

Biotin

Acrylates/C10-30 Alkyl Acrylate Crosspolymer

Cetyl Stearate

Pyridoxine Hcl

Cetyl Alcohol

Isostearyl Isostearate

Potassium Cetyl Phosphate

Sodium PCA

Hydroxyphenyl Propamidobenzoic Acid

Stearic Acid

Potassium Lactate

Sodium Chloride

Citric Acid

Lactic Acid

Sodium Hydroxide

Potassium Sorbate

Sodium Benzoate

Caprylyl Glycol

Decyl Glucoside

Lauryl Glucoside

Water, Lactococcus Ferment Lysate, Glycerin, Butylene Glycol, Polysorbate 20, Niacinamide, Panthenol, Cucumis Sativus Fruit Extract, Beta Vulgaris Root Extract, Daucus Carota Sativa Extract, Avena Sativa Bran Extract, Hydrolyzed Hemp Seed Protein, Aloe Barbadensis Leaf Extract, Zingiber Officinale Root Extract, Sodium Hyaluronate, Fructooligosaccharides, Biotin, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Cetyl Stearate, Pyridoxine Hcl, Pentylene Glycol, Cetyl Alcohol, Isostearyl Isostearate, Potassium Cetyl Phosphate, Sodium PCA, Sodium Phytate, Hydroxyphenyl Propamidobenzoic Acid, Stearic Acid, Potassium Lactate, Sodium Chloride, Citric Acid, Lactic Acid, Sodium Hydroxide, Potassium Sorbate, Sodium Benzoate, Caprylyl Glycol, Phenoxyethanol, Decyl Glucoside, Lauryl Glucoside

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Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Niacinamide is a multitasking form of vitamin B3 that strengthens the skin barrier, reduces pores and dark spots, regulates oil, and improves signs of aging.

And the best part? It's gentle and well-tolerated by most skin types, including sensitive and reactive skin.

You might have heard of "niacin flush", or the reddening of skin that causes itchiness. Niacinamide has not been found to cause this.

In very rare cases, some individuals may not be able to tolerate niacinamide at all or experience an allergic reaction to it.

If you are experiencing flaking, irritation, and dryness with this ingredient, be sure to double check all your products as this ingredient can be found in all categories of skincare.

When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.

When you apply niacinamide to your skin, your body converts it into nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme that is already found in your cells as "fuel" and powers countless biological processes.

In your skin, NAD helps repair cell damage, produce new healthy cells, support collagen production, strengthen the skin barrier, and fight environmental stressors (like UV and pollution).

Our natural NAD levels start to decline with age, leading to slower skin repair, visible aging, and a weaker skin barrier. By providing your skin niacinamide, you're recharging your skin's NAD levels. This leads to stronger, healthier, and younger looking skin.

Another name for vitamin B3 is nicotinamide. This vitamin is water-soluble and our bodies don't store it. We obtain Vitamin B3 from either food or skincare. Meat, fish, wheat, yeast, and leafy greens contain vitamin B3.

The type of niacinamide used in skincare is synthetically created.

Panthenol is a common ingredient that helps hydrate and soothe the skin. It is found naturally in our skin and hair.

There are two forms of panthenol: D and L.

D-panthenol is also known as dexpanthenol. Most cosmetics use dexpanthenol or a mixture of D and L-panthenol.

Panthenol is famous due to its ability to go deeper into the skin's layers. Using this ingredient has numerous pros (and no cons):

Like hyaluronic acid, panthenol is a humectant. Humectants are able to bind and hold large amounts of water to keep skin hydrated.

This ingredient works well for wound healing. It works by increasing tissue in the wound and helps close open wounds.

Once oxidized, panthenol converts to pantothenic acid. Panthothenic acid is found in all living cells.

This ingredient is also referred to as pro-vitamin B5.

Pentylene Glycol (1,2-pentanediol) is a multitasking little diol with three main roles in a formula:

Research on alkanediols (the family pentylene glycol belongs to) show they work by disrupting microbial cell membranes. This disruption helps the primary preservative system in a product work more effectively at lower doses.

On the safety side, the Cosmetic Ingredient Review Expert Panel has concluded this ingredient to be safe as used in current cosmetic practices + concentrations.

Typical use levels in a formula run about 1-5%.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Sodium Phytate is the synthetic salt form of phytic acid. Phytic acid is an antioxidant and can be found in plant seeds.

Sodium Phytate is a chelating agent. Chelating agents help prevent metals from binding to water. This helps stabilize the ingredients and the product.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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