Skin science article
PCA Skin Pro-Max Age Renewal Advanced Serum Versus PCA Skin Exlinea Pro Peptide Serum
PCA Skin Pro-Max Age Renewal Advanced Serum Versus PCA Skin Exlinea Pro Peptide Serum This anti-aging serum is formulated around Sodium Hyaluronate and Acetyl Octapeptide-3 to soften the look of wrinkles and hydrate skin. This anti-aging serum is formulated ar
PCA Skin Pro-Max Age Renewal Advanced Serum Versus PCA Skin Exlinea Pro Peptide Serum
This anti-aging serum is formulated around Sodium Hyaluronate and Acetyl Octapeptide-3 to soften the look of wrinkles and hydrate skin.
This anti-aging serum is formulated around Acetyl Octapeptide-3 and Acetyl Hexapeptide-8 to soften the look of wrinkles.
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Polysilicone-11
Propanediol
Glycerin
Butylene Glycol
PPG-3 Benzyl Ether Myristate
Polysorbate 20
Sodium Polyacryloyldimethyl Taurate
Caprylyl Glycol
Sodium Benzoate
Hydroxypropyl Methylcellulose
Sodium Hyaluronate
Ethylene Brassylate
Pullulan
Hydrolyzed Hyaluronic Acid
Potassium Sorbate
Sodium Acetylated Hyaluronate
Lactic Acid
Laureth-12
Carnosine
Tricholoma Matsutake Extract
Phenoxyethanol
Hdi/Trimethylol Hexyllactone Crosspolymer
Polymethylsilsesquioxane
Anigozanthos Flavidus Extract
Porphyridium Cruentum Extract
Pentylene Glycol
Ethylhexylglycerin
Bacillus Ferment
Sodium Hyaluronate Crosspolymer
Acetyl Octapeptide-3
Acetyl Tripeptide-54 Amide
Acetyl Tripeptide-74 Amide
Palmitoyl Sh-Tripeptide-1 Amide
Palmitoyl Sh-Tripeptide-3 Amide
Ergothioneine
Water, Polysilicone-11, Propanediol, Glycerin, Butylene Glycol, PPG-3 Benzyl Ether Myristate, Polysorbate 20, Sodium Polyacryloyldimethyl Taurate, Caprylyl Glycol, Sodium Benzoate, Hydroxypropyl Methylcellulose, Sodium Hyaluronate, Ethylene Brassylate, Pullulan, Hydrolyzed Hyaluronic Acid, Potassium Sorbate, Sodium Acetylated Hyaluronate, Lactic Acid, Laureth-12, Carnosine, Tricholoma Matsutake Extract, Phenoxyethanol, Hdi/Trimethylol Hexyllactone Crosspolymer, Polymethylsilsesquioxane, Anigozanthos Flavidus Extract, Porphyridium Cruentum Extract, Pentylene Glycol, Ethylhexylglycerin, Bacillus Ferment, Sodium Hyaluronate Crosspolymer, Acetyl Octapeptide-3, Acetyl Tripeptide-54 Amide, Acetyl Tripeptide-74 Amide, Palmitoyl Sh-Tripeptide-1 Amide, Palmitoyl Sh-Tripeptide-3 Amide, Ergothioneine
Glyceryl Isostearate
Isostearyl Isostearate
C13-15 Alkane
Betaine
Acrylates/C10-30 Alkyl Acrylate Crosspolymer
Xanthan Gum
Methyl Gluceth-20
Oryza Sativa Starch
Polyglyceryl-3 Laurate
Sodium Levulinate
Levulinic Acid
Polyglyceryl-6 Oleate
Hydrolyzed Wheat Protein
Hydrolyzed Soy Protein
Sodium Hydroxide
Tetrasodium Glutamate Diacetate
Pectin
Hydroxyethylcellulose
Arginine
Proline
Serine
Glucose
Bacillus/Soybean Ferment Extract
Chondrus Crispus Extract
Acetyl Hexapeptide-8
Disodium Phosphate
Polysorbate 60
Sodium Phosphate
Water, Glycerin, Pentylene Glycol, Glyceryl Isostearate, Isostearyl Isostearate, C13-15 Alkane, Betaine, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Xanthan Gum, Methyl Gluceth-20, Oryza Sativa Starch, Polyglyceryl-3 Laurate, Sodium Levulinate, Caprylyl Glycol, Levulinic Acid, Polyglyceryl-6 Oleate, Hydrolyzed Wheat Protein, Ethylhexylglycerin, Hydrolyzed Soy Protein, Sodium Hydroxide, Tetrasodium Glutamate Diacetate, Butylene Glycol, Pectin, Hydroxyethylcellulose, Arginine, Proline, Serine, Glucose, Acetyl Octapeptide-3, Bacillus/Soybean Ferment Extract, Sodium Hyaluronate, Chondrus Crispus Extract, Acetyl Hexapeptide-8, Disodium Phosphate, Polysorbate 60, Sodium Phosphate
Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Acetyl Octapeptide-3 is a synthetic peptide also commonly known as SNAP-8. It is a lab-made peptide often marketed as a gentler, topical alternative to Botox.
It works by mimicking part of a protein involved in muscle contractions, which may help relax facial tension and reduce the appearance of fine lines (mostly around the eyes and forehead).
It’s considered a “next-gen” version of Argireline (Acetyl Hexapeptide-8), an older peptide with more research behind it that also supports collagen production.
SNAP-8 showed slightly better results than Argireline in one small manufacturer-funded study, but there’s limited independent research. Plus, most tests use concentrations higher than what’s typically found in skincare products.
This ingredient might offer a subtle smoothing effect but it won't don’t deliver the dramatic results of actual Botox injections.
Think of it more like a supporting actor in your skincare lineup.
Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.
Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.
Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).
Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:
The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.
Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.
Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Pentylene Glycol (1,2-pentanediol) is a multitasking little diol with three main roles in a formula:
Research on alkanediols (the family pentylene glycol belongs to) show they work by disrupting microbial cell membranes. This disruption helps the primary preservative system in a product work more effectively at lower doses.
On the safety side, the Cosmetic Ingredient Review Expert Panel has concluded this ingredient to be safe as used in current cosmetic practices + concentrations.
Typical use levels in a formula run about 1-5%.
Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.
In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.
Interestingly, the size of the molecule affects its behavior:
Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.
Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.
You'll typically see concentrations between 0.1-2% for this ingredient.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!