Skin science article
Peter Thomas Roth Potent-C Power Serum Versus Paula's Choice Resist Ultra-Light Super Antioxidant Concentrate Serum
Peter Thomas Roth Potent-C Power Serum Versus Paula's Choice Resist Ultra-Light Super Antioxidant Concentrate Serum This brightening serum is formulated around Tetrahexyldecyl Ascorbate and Tocopheryl Acetate to brighten dull-looking skin and soften the look o
Peter Thomas Roth Potent-C Power Serum Versus Paula's Choice Resist Ultra-Light Super Antioxidant Concentrate Serum
This brightening serum is formulated around Tetrahexyldecyl Ascorbate and Tocopheryl Acetate to brighten dull-looking skin and soften the look of wrinkles.
This anti-aging serum is formulated around Resveratrol and Niacinamide to soften the look of wrinkles and calm redness.
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Tetrahexyldecyl Ascorbate
Butylene Glycol
C9-12 Alkane
Caprylyl Methicone
Tocopheryl Acetate
C10-18 Triglycerides
Polyglyceryl-6 Distearate
Ferulic Acid
Squalane
Hydrogenated Lecithin
Propanediol
Sodium Hyaluronate
Zingiber Officinale Root Extract
Curcuma Longa Root Extract
Panax Ginseng Root Extract
Jojoba Esters
Leuconostoc/Radish Root Ferment Filtrate
Coco-Caprylate/Caprate
Glycerin
Cetyl Alcohol
Polyglyceryl-3 Beeswax
Xanthan Gum
Disodium EDTA
Mica
Ethylhexylglycerin
Potassium Sorbate
Sodium Benzoate
Phenoxyethanol
Water, Tetrahexyldecyl Ascorbate, Butylene Glycol, C9-12 Alkane, Caprylyl Methicone, Tocopheryl Acetate, C10-18 Triglycerides, Polyglyceryl-6 Distearate, Ferulic Acid, Squalane, Hydrogenated Lecithin, Propanediol, Sodium Hyaluronate, Zingiber Officinale Root Extract, Curcuma Longa Root Extract, Panax Ginseng Root Extract, Jojoba Esters, Leuconostoc/Radish Root Ferment Filtrate, Coco-Caprylate/Caprate, Glycerin, Cetyl Alcohol, Polyglyceryl-3 Beeswax, Xanthan Gum, Disodium EDTA, Mica, Ethylhexylglycerin, Potassium Sorbate, Sodium Benzoate, Phenoxyethanol
Cyclopentasiloxane
Dimethicone
Polysorbate 20
Polysilicone-11
Lauryl PEG-9 Polydimethylsiloxyethyl Dimethicone
Hyaluronic Acid
Resveratrol
Niacinamide
Quercetin
Adenosine
Tocopherol
Phospholipids
Ubiquinone
Epigallocatechin Gallate
Sea Whip Extract
Bisabolol
Beta-Glucan
Phytic Acid
Acrylates/C10-30 Alkyl Acrylate Crosspolymer
Sodium Hydroxide
Water, Cyclopentasiloxane, Butylene Glycol, Dimethicone, Glycerin, Polysorbate 20, Polysilicone-11, Lauryl PEG-9 Polydimethylsiloxyethyl Dimethicone, Hyaluronic Acid, Resveratrol, Niacinamide, Quercetin, Adenosine, Tetrahexyldecyl Ascorbate, Tocopherol, Phospholipids, Ubiquinone, Epigallocatechin Gallate, Sea Whip Extract, Bisabolol, Beta-Glucan, Phytic Acid, Xanthan Gum, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Sodium Hydroxide, Disodium EDTA, Ethylhexylglycerin, Phenoxyethanol
Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
Disodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air.
This ingredient mainly works behind the scenes and helps with:
On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it.
One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin).
Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption.
You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%.
Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:
The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.
Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.
Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).
It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.
On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.
Another perk of this ingredient is that it stays functional across a wide pH range (3-10).
You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.
Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.
Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.
Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.
Tetrahexyldecyl Ascorbate (THD) is a stable and oil-soluble form of Vitamin C.
THD is special in that it has the ability to travel deeper into skin than traditional ascorbic acid while maintaining the same skin benefits (double win!).
Because it’s oil-soluble, THD dives deep into your skin’s fatty layers (think ceramides and cholesterol) to fight off the kind of free radicals that mess with your skin barrier. This makes it a great pair with water-based vitamin C (ascorbic acid) that mainly works on the surface.
Even at just 0.1%, THD is already showing great antioxidant activity. When used up to 2%, it helps keep your skin happy and calm, especially when it’s stressed from pollution or sun.
Want to fade dark spots or tackle hyperpigmentation? You’ll want 5% or more. Pairing it with brightening buddies like niacinamide or licorice root gives even better results. One study even used 30% THD with other brighteners and saw real results on stubborn discoloration, even in melasma-prone skin.
A note on THD: It’s has a slightly silky, oily texture and usually shows up colorless or pale yellow (though the exact shade can vary by supplier).
While you can sneak it into water-based formulas, it really shines when paired with silicones or oils, which help your skin soak it up better.
THD is pretty stable, but it’s still vulnerable to degradation like ascorbic acid. Too much light or heat (above 113°F / 45°C) can break it down over time. Go for dark and opaque packaging that keeps it safe and shady!
Read more about other types of Vitamin C:
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.
On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.
Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.