Peptide Skincare & BeautySkin science and ingredient guides

Skin science article

Pond's Rejuveness Anti-Wrinkle Cream Versus Naturium Multi-Peptide Moisturizer

Pond's Rejuveness Anti-Wrinkle Cream Versus Naturium Multi-Peptide Moisturizer This anti-aging day moisturizer is formulated around Lactic Acid to soften the look of wrinkles and refine skin texture. This anti-aging moisturizer is formulated around Palmitoyl T

Pond's Rejuveness Anti-Wrinkle Cream Versus Naturium Multi-Peptide Moisturizer

This anti-aging day moisturizer is formulated around Lactic Acid to soften the look of wrinkles and refine skin texture.

This anti-aging moisturizer is formulated around Palmitoyl Tripeptide-5 and Palmitoyl Tripeptide-1 to soften the look of wrinkles.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Lactic Acid

Glycerin

Butylene Glycol

Cetyl Alcohol

Isopropyl Palmitate

Steareth-21

Dimethicone

Paraffinum Liquidum

Ethylhexyl Methoxycinnamate

Steareth-2

Potassium Hydroxide

Stearyl Dimethicone

Stearic Acid

Borago Officinalis Seed Oil

Magnesium Aluminum Silicate

Phenoxyethanol

Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer

Parfum

Octadecene

Isohexadecane

Methylparaben

Hydroxyethylcellulose

Dimethiconol

Xanthan Gum

Disodium EDTA

Tocopheryl Acetate

Propylparaben

Benzophenone-3

Polysorbate 60

Potassium Carbonate

Sorbitan Isostearate

Sodium Nitrate

Tocopherol

Quartz

Ascorbyl Palmitate

Disodium Phosphate

BHT

Phospholipids

Sodium Phosphate

Hydrolyzed Collagen

Cholesterol

Citronellol

Citrus Aurantium Peel Oil

Coumarin

Geraniol

Hexyl Cinnamal

Limonene

Linalool

Linalyl Acetate

Terpineol

Tetramethyl Acetyloctahydronaphthalenes

CI 77891

Water, Lactic Acid, Glycerin, Butylene Glycol, Cetyl Alcohol, Isopropyl Palmitate, Steareth-21, Dimethicone, Paraffinum Liquidum, Ethylhexyl Methoxycinnamate, Steareth-2, Potassium Hydroxide, Stearyl Dimethicone, Stearic Acid, Borago Officinalis Seed Oil, Magnesium Aluminum Silicate, Phenoxyethanol, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Parfum, Octadecene, Isohexadecane, Methylparaben, Hydroxyethylcellulose, Dimethiconol, Xanthan Gum, Disodium EDTA, Tocopheryl Acetate, Propylparaben, Benzophenone-3, Polysorbate 60, Potassium Carbonate, Sorbitan Isostearate, Sodium Nitrate, Tocopherol, Quartz, Ascorbyl Palmitate, Disodium Phosphate, BHT, Phospholipids, Sodium Phosphate, Hydrolyzed Collagen, Cholesterol, Citronellol, Citrus Aurantium Peel Oil, Coumarin, Geraniol, Hexyl Cinnamal, Limonene, Linalool, Linalyl Acetate, Terpineol, Tetramethyl Acetyloctahydronaphthalenes, CI 77891

Simmondsia Chinensis Seed Oil

Squalane

Glyceryl Stearate

Niacinamide

Stearyl Alcohol

Palmitoyl Tripeptide-5

Pantolactone

Palmitoyl Tripeptide-1

Palmitoyl Tetrapeptide-7

Hydrolyzed Plukenetia Volubilis Seed Extract

Dunaliella Salina Extract

Sodium Hyaluronate

3-O-Ethyl Ascorbic Acid

Panthenol

Caryodendron Orinocense Seed Oil

Honokiol

Magnolol

Palmitic Acid

Sorbitan Oleate

Aluminum Starch Octenylsuccinate

Hydroxyacetophenone

Acrylamide/Sodium Acryloyldimethyltaurate Copolymer

Polyglyceryl-6 Laurate

1,2-Hexanediol

Boron Nitride

Caprylyl Glycol

Polyglyceryl-10 Oleate

Chlorphenesin

Acrylates/C10-30 Alkyl Acrylate Crosspolymer

Polysorbate 80

Sorbitan Palmitate

Sodium Hydroxide

Sodium Benzoate

Carbomer

Sodium Lactate

Polysorbate 20

Citric Acid

Ethylhexylglycerin

Potassium Sorbate

Water, Glycerin, Dimethicone, Simmondsia Chinensis Seed Oil, Squalane, Glyceryl Stearate, Cetyl Alcohol, Niacinamide, Stearyl Alcohol, Palmitoyl Tripeptide-5, Pantolactone, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Hydrolyzed Plukenetia Volubilis Seed Extract, Dunaliella Salina Extract, Sodium Hyaluronate, 3-O-Ethyl Ascorbic Acid, Panthenol, Caryodendron Orinocense Seed Oil, Honokiol, Magnolol, Palmitic Acid, Sorbitan Oleate, Aluminum Starch Octenylsuccinate, Hydroxyacetophenone, Stearic Acid, Acrylamide/Sodium Acryloyldimethyltaurate Copolymer, Polyglyceryl-6 Laurate, 1,2-Hexanediol, Boron Nitride, Caprylyl Glycol, Polyglyceryl-10 Oleate, Isohexadecane, Butylene Glycol, Chlorphenesin, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Tocopheryl Acetate, Polysorbate 80, Sorbitan Palmitate, Sodium Hydroxide, Sodium Benzoate, Carbomer, Sodium Lactate, Phenoxyethanol, Polysorbate 20, Citric Acid, Ethylhexylglycerin, Potassium Sorbate

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Cetyl Alcohol is a fatty alcohol. Fatty Alcohols are most often used as an emollient or to thicken a product.

Its main roles are:

Though it has "alcohol" in the name, it is not related to denatured alcohol or ethyl alcohol.

The FDA allows products labeled "alcohol-free" to have fatty alcohols.

This ingredient may not be fungal acne safe. It is a primary fatty alcohol with a chain length above 12 carbons. A study from 2019 show Malassezia can feed on fatty alcohols in this range, so it may trigger fungal acne in those prone to it.

Dimethicone is a type of synthetic silicone created from natural materials such as quartz. It is also known as polydimethylsiloxane.

What it does:

Dimethicone comes in different viscosities:

Depending on the viscosity, dimethicone has different properties.

Ingredients lists don't always show which type is used, so we recommend reaching out to the brand if you have questions about the viscosity.

This ingredient is unlikely to cause irritation because it does not get absorbed into skin. However, people with silicone allergies should be careful about using this ingredient.

Note: Dimethicone may contribute to pilling. This is because it is not oil or water soluble, so pilling may occur when layered with products. When mixed with heavy oils in a formula, the outcome is also quite greasy.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Isohexadecane is added to enhance texture, emulsify, and to help cleanse. It is an isoparrafin. It is a component of petrolatum.

Due to its large size, Isohexadecane is not absorbed by the skin. Instead, it sits on top and acts as an emollient. Emollients help keep your skin soft and smooth by trapping moisture within.

Isohexadecane is often used in products designed to help oily skin. It is lightweight and non-greasy while helping to moisturize. When mixed with silicones, it gives a product a silky feel.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Stearic Acid is a fatty acid that is already found in your skin. It's one of the free fatty acids that works alongside ceramides and cholesterols to maintain your barrier.

In cosmetics, it is a multitasker:

Safety-wise, the CIR Expert Panel has concluded it to be safe in cosmetics when formulated to be non-irritating and non-sensitizing.

Free stearic acid is a C18 fatty acid that the Malassezia yeast can substrate, so this ingredient may not be fungal acne safe.

Tocopheryl Acetate is a stable, shelf-friendly form of vitamin E.

Formulators love it because plain vitamin E oxidizes quickly once it hits air. This acetate version stays stable and resists going off, helping to extend a product's shelf life.

It's actually inactive on its own and works like a slow-release "storage" form; the enzymes in your skin called esterases gradually convert it into active vitamin E over time.

One in vivo study showed 5% of the acetate in the living layer of the epidermis converted to vitamin E after 5 days of application. This study also found the skin gained protection against UV damage even though the conversion was slow and small.

Once converted, vitamin E acts as a skin's main fat-soluble antioxidant that fights free radicals to protect skin from damage.

Topical vitamin E generally boosts the skin's photoprotection, and it reduced UV-damage in animal models.

This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.

Overall, it has a pretty solid safety profile and has been found to be non-irritating and non-comedogenic. Allergic reactions may happen but stay rare due to how widely the ingredient gets used.

The concentration will vary depending on the formula; industry data shows 0.1% in baby lotions, 3% in lipsticks, and 5% in foot powders. You can also find this ingredient at 100% in a pure vitamin E oil.

Most leave-on skincare keeps it at the lower end, often between 0.5-1%.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Similar Comparisons

The reference edit

Ingredients, questions
& further reading.

Connected source records selected through this article’s public topic index.

01

Formula cabinet

Ingredients & structured notes

Ingredient index

Ingredients Side-by-side

  1. 01Water
  2. 02Glycerin
  3. 03Dimethicone
  4. 04Simmondsia Chinensis Seed Oil
  5. 05Squalane
  6. 06Glyceryl Stearate
  7. 07Cetyl Alcohol
  8. 08Niacinamide
  9. 09Stearyl Alcohol
  10. 10Palmitoyl Tripeptide-5
  11. 11Pantolactone
  12. 12Palmitoyl Tripeptide-1
  13. 13Palmitoyl Tetrapeptide-7
  14. 14Hydrolyzed Plukenetia Volubilis Seed Extract
  15. 15Dunaliella Salina Extract
  16. 16Sodium Hyaluronate
  17. 173-O-Ethyl Ascorbic Acid
  18. 18Panthenol
  19. 19Caryodendron Orinocense Seed Oil
  20. 20Honokiol
Source · skinsort.com
02

Product index

Related product references

Product

Naturium Multi-Peptide Moisturizer

Naturium Multi-Peptide Moisturizer Ingredients in Naturium Multi-Peptide Moisturizer explained: benefits, concerns, and detailed analysis of 48 ingredients including Water, Glycerin, and Di…

Source: skinsort.comView reference →
03

Comparison edit

Read side by side