Regimen Lab Level Serum Versus Paula's Choice 10% Azelaic Acid Booster

Regimen Lab Level Serum Versus Paula's Choice 10% Azelaic Acid Booster

This brightening serum is formulated around Niacinamide and Tranexamic Acid to fade the look of dark spots and brighten dull-looking skin.

This calming treatment is formulated around Azelaic Acid and Salicylic Acid to calm redness and fade the look of dark spots.

What's inside

Key Ingredients

Benefits

Concerns

No concerns

Ingredients Side-by-side

Water

Propanediol

Niacinamide

Betaine

Dimethyl Isosorbide

Tranexamic Acid

Acetyl Glucosamine

Alpha-Arbutin

Undecylenoyl Phenylalanine

Glycyrrhiza Glabra Root Extract

Dipotassium Glycyrrhizate

Tetrahydrodiferuloylmethane

Hexylresorcinol

Dimethylmethoxy Chromanol

Xanthan Gum

Lecithin

Sclerotium Gum

Pullulan

Disodium EDTA

Sodium Hydroxide

Chlorphenesin

Caprylyl Glycol

Phenoxyethanol

Ethylhexylglycerin

Water, Propanediol, Niacinamide, Betaine, Dimethyl Isosorbide, Tranexamic Acid, Acetyl Glucosamine, Alpha-Arbutin, Undecylenoyl Phenylalanine, Glycyrrhiza Glabra Root Extract, Dipotassium Glycyrrhizate, Tetrahydrodiferuloylmethane, Hexylresorcinol, Dimethylmethoxy Chromanol, Xanthan Gum, Lecithin, Sclerotium Gum, Pullulan, Disodium EDTA, Sodium Hydroxide, Chlorphenesin, Caprylyl Glycol, Phenoxyethanol, Ethylhexylglycerin

Azelaic Acid

C12-15 Alkyl Benzoate

Caprylic/Capric Triglyceride

Methyl Glucose Sesquistearate

Glycerin

Cetearyl Alcohol

Glyceryl Stearate

Dimethicone

Salicylic Acid

Adenosine

Boerhavia Diffusa Root Extract

Allantoin

Bisabolol

Cyclopentasiloxane

Butylene Glycol

Water, Azelaic Acid, C12-15 Alkyl Benzoate, Caprylic/Capric Triglyceride, Methyl Glucose Sesquistearate, Glycerin, Cetearyl Alcohol, Glyceryl Stearate, Dimethicone, Salicylic Acid, Adenosine, Glycyrrhiza Glabra Root Extract, Boerhavia Diffusa Root Extract, Allantoin, Bisabolol, Cyclopentasiloxane, Xanthan Gum, Sclerotium Gum, Propanediol, Butylene Glycol, Phenoxyethanol

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Glycyrrhiza Glabra Root Extract is an extract of the roots of Licorice. It has been found to have several benefits such as skin hydrating, conditioning, and soothing.

One component, glabridin, has extra potent antioxidant and soothing properties. It has also been found to block pigmentation from UVB rays in guinea pigs.

Licorice Root also contains a flavonoid. Flavonoids are a natural substance from in plants. Flavonoids also have antioxidant properties.

Another component, glycyrrhizin, has been found to have anti-inflammatory and antimicrobial benefits. This may make licorice root extract effective at treating acne. However, more research is needed to support this.

Liquiritin is one of the flavone compounds found in licorice. It has been found to help lighten skin by preventing tyrosinase from reacting with tyrosine. When the two react, protein is converted to melanin. Melanin is the substance in your body that gives your features pigmentation.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Propanediol is an all-star ingredient. It softens, hydrates, and smooths the skin.

It’s often used to:

Propanediol is not likely to cause sensitivity and considered safe to use. It is derived from corn or petroleum with a clear color and no scent.

Sclerotium Gum is a natural sugar-based fiber made by fermenting a fungus called Sclerotium rolfsii. It's often used as the plant-friendly alternative for synthetic thickeners like carbomer.

In skincare, it works as a thickener, gel former, and stabilizer that keeps heavy ingredients suspended so a product does not separate.

It is non-ionic and forms a triple helix in solution. This is just a fancy way of saying it builds a smooth, cushiony, and non-sticky gel that feels silkier than many other gums.

Another perk of this ingredient is that it is very sturdy and holds up across a wide pH range (~2-11). It's also good at resisting heat and hydrolysis.

Since it holds water at the skin surface, it can provide some light hydration as well.

Typical use levels are around 0.25-2%; formulators usually use 0.2-0.5% to thicken lotions and up to 2% for a firmer gel base.

This ingredient has been found safe in cosmetics with no meaningful evidence of skin sensitization.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.

On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.

Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.

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