Peptide Skincare & BeautySkin science and ingredient guides

Skin science article

Skin Treats Niacinamide Serum Versus Skin Treats Hyaluronic Acid Serum

Skin Treats Niacinamide Serum Versus Skin Treats Hyaluronic Acid Serum This barrier-repair serum is formulated around Niacinamide to strengthen the skin barrier and calm redness. This hydrating serum is formulated around Sodium Hyaluronate and Allantoin to hyd

Skin Treats Niacinamide Serum Versus Skin Treats Hyaluronic Acid Serum

This barrier-repair serum is formulated around Niacinamide to strengthen the skin barrier and calm redness.

This hydrating serum is formulated around Sodium Hyaluronate and Allantoin to hydrate skin and strengthen the skin barrier.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Glycerin

Propylene Glycol

Niacinamide

Xanthan Gum

Hydroxyacetophenone

Phenoxyethanol

Sodium Hyaluronate

Glyceryl Acrylate/Acrylic Acid Copolymer

Pvm/Ma Copolymer

1,2-Hexanediol

Iodopropynyl Butylcarbamate

Stephania Tetrandra Root Extract

Gentiana Scabra Root Extract

Water, Glycerin, Propylene Glycol, Niacinamide, Xanthan Gum, Hydroxyacetophenone, Phenoxyethanol, Sodium Hyaluronate, Glyceryl Acrylate/Acrylic Acid Copolymer, Pvm/Ma Copolymer, 1,2-Hexanediol, Iodopropynyl Butylcarbamate, Stephania Tetrandra Root Extract, Gentiana Scabra Root Extract

Sericin

Carboxymethyl Chitosan

PEG-40 Hydrogenated Castor Oil

Allantoin

2-Bromo-2-Nitropropane-1,3-Diol

PEG-3 Dioleate

Water, Propylene Glycol, Glycerin, Sericin, Carboxymethyl Chitosan, Gentiana Scabra Root Extract, PEG-40 Hydrogenated Castor Oil, Xanthan Gum, Allantoin, Sodium Hyaluronate, 2-Bromo-2-Nitropropane-1,3-Diol, PEG-3 Dioleate

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

We don't have a description for Gentiana Scabra Root Extract yet.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Propylene Glycol is a synthetic, colorless, odorless liquid that has been a staple in cosmetics for decades. It is a skin conditioning agent, humectant, and solvent.

As a humectant, it draw water to the skin to reduce flaking and restore suppleness. It's also a solvent that helps dissolve other actives and keeps formulas stable across temperature changes.

The CIR Expert Panel has confirmed this ingredient to be nontoxic and clinical studies show no sensitization at cosmetic use concentrations.

True allergic reactions are quite rare: a 15-year retrospective study of 6,751 patients found only 0.31% had a positive reaction (and less than half were considered clinically relevant).

It seemed that when sensitization does occur, it's most commonly linked to topical medication (like corticosteroids) and not cosmetics. Allergic contact dermatitis also appears largely limited to individuals with underlying skin conditions.

Overall, propylene glycol is a well-studied ingredient that most people can tolerate without issue.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.

On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.

Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.

Similar Comparisons

The reference edit

Ingredients, questions
& further reading.

Connected source records selected through this article’s public topic index.

01

Formula cabinet

Ingredients & structured notes

Ingredient index

Ingredients Explained

  1. 01These ingredients are found in both products.
  2. 02Ingredients higher up in an ingredient list are typically present in a larger amount.
  3. 031,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.
  4. 04It is a:
  5. 05Humectant, drawing moisture into the skin
  6. 06Emollient, helping to soften skin
  7. 07Solvent, dispersing and stabilizing formulas
  8. 08Preservative booster, enhancing the antimicrobial activity of other preservatives
  9. 09Betaine is a humectant. Like hyaluronic acid, it helps attract and retain moisture in the skin. It’s known for being gentle and for helping the skin maintain balanced hydration.
  10. 10Betaine is mainly used to improve hydration and support calmer skin. It helps skin cells regulate water balance because it functions as an osmolyte.
  11. 11Some studies suggest betaine may support making skin tone more even.
  12. 12Fun fact: Betaine naturally exists in the skin and the body. In cosmetic products, it can be either plant-derived (most commonly from sugar beets) or synthetically produced for consistency and stability.
  13. 13Betaine is also known as trimethylglycine.
  14. 14Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:
  15. 15Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
  16. 16Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
  17. 17Carbomer is a synthetic thickening and gelling agent. It's basically the ingredient that gives a lot of serums, gels, creams, and sunscreens their smooth, non-sticky texture.
  18. 18Although legally permitted at very high levels, carbomers are normally used at concentrations below 1%.
  19. 19It also needs to be neutralized to actually thicken, and because it is a large molecule, it doesn't really penetrate the skin barrier.
  20. 20Allergy-wise, the risk is very low. Clinical studies show carbomers have low potential for skin irritation/sensitization even at concentrations up to 100%.
Source · skinsort.com
02

Product index

Related product references

Product

Me-Just For You Hyaluronic Acid Serum

Me-Just For You Hyaluronic Acid Serum Me-Just For You Hyaluronic Acid Serum ingredients explained: Aqua, Hyaluronic Acid (2%), Squalane, Tocopherol Acetate, Magnesium Ascorbyl Phosphate, Si…

Source: incidecoder.comView reference →
03

Comparison edit

Read side by side

04

Ask the journal

Related questions

01How to Apply Face Serums

Skincare rules can get confusing, but when it comes to application the general rule of thumb is to pay attention to the product’s consistency. “Apply the lightest, thinnest product first and the heaviest, and more dense products last, since thinner products can’t penetrate thicker products,”says Dr. Lewis. After cleansing the face and following up with a toner, let the skin dry before using a serum. You can layer different serums on top of each other or opt for a product that has a precise mix of multiple hero ingredients, such as hyaluronic acid and vitamin C.

Source · www.skincare.com
02When and How to Use Hyaluronic Acid in Your Routine

Products with hyaluronic acid can be used in the morning or at night (or both!). Applying the hydrating ingredient at night will restore your skin’s resilience while you sleep, and applying it in the morning will leave your skin feeling plump, hydrated and ready for makeup. Hyaluronic acid is great at providing topical hydration when it’s introduced into a balanced skincare routine. According to Dr. King, it’s important to pair your hyaluronic acid products with an emollient or occlusive moisturizer to lock in hydration.

Source · www.skincare.com