Skin science article
SkinBetter Science AlphaRet Clearing Serum Versus Allies of Skin Retinal & Peptides Repair Night Cream
SkinBetter Science AlphaRet Clearing Serum Versus Allies of Skin Retinal & Peptides Repair Night Cream This acne serum is formulated around Lactic Acid and Ethyl Lactyl Retinoate to clear breakouts and refine skin texture. This anti-aging night moisturizer is
SkinBetter Science AlphaRet Clearing Serum Versus Allies of Skin Retinal & Peptides Repair Night Cream
This acne serum is formulated around Lactic Acid and Ethyl Lactyl Retinoate to clear breakouts and refine skin texture.
This anti-aging night moisturizer is formulated around Palmitoyl Tetrapeptide-7 and Niacinamide to soften the look of wrinkles and strengthen the skin barrier.
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Lactic Acid
Sodium Lactate
Pentylene Glycol
Ethylhexyl Olivate
Sorbitan Stearate
Neopentyl Glycol Diethylhexanoate
PPG-3 Isostearyl Methyl Ether
Glycerin
Dimethyl Isosorbide
Glyceryl Stearate
PEG-100 Stearate
Magnesium Aluminum Silicate
Niacinamide
Zinc PCA
Steareth-2
Ethyl Lactyl Retinoate
Salicylic Acid
Oligopeptide-10
Sodium Hyaluronate
Decylene Glycol
Artemisia Vulgaris Extract
Bisabolol
Tocopheryl Acetate
Camellia Sinensis Leaf Extract
Laminaria Digitata Extract
Tasmannia Lanceolata Fruit/Leaf Extract
Boswellia Serrata Extract
Zingiber Officinale Root Extract
Honey Extract
Oryza Sativa Bran Extract
Cetearyl Alcohol
Butylene Glycol
Xanthan Gum
Lecithin
Sclerotium Gum
Disodium EDTA
Pullulan
Ethylhexylglycerin
Silica
Phenoxyethanol
Sodium Benzoate
Water, Lactic Acid, Sodium Lactate, Pentylene Glycol, Ethylhexyl Olivate, Sorbitan Stearate, Neopentyl Glycol Diethylhexanoate, PPG-3 Isostearyl Methyl Ether, Glycerin, Dimethyl Isosorbide, Glyceryl Stearate, PEG-100 Stearate, Magnesium Aluminum Silicate, Niacinamide, Zinc PCA, Steareth-2, Ethyl Lactyl Retinoate, Salicylic Acid, Oligopeptide-10, Sodium Hyaluronate, Decylene Glycol, Artemisia Vulgaris Extract, Bisabolol, Tocopheryl Acetate, Camellia Sinensis Leaf Extract, Laminaria Digitata Extract, Tasmannia Lanceolata Fruit/Leaf Extract, Boswellia Serrata Extract, Zingiber Officinale Root Extract, Honey Extract, Oryza Sativa Bran Extract, Cetearyl Alcohol, Butylene Glycol, Xanthan Gum, Lecithin, Sclerotium Gum, Disodium EDTA, Pullulan, Ethylhexylglycerin, Silica, Phenoxyethanol, Sodium Benzoate
Caprylic/Capric Triglyceride
Propanediol
Argania Spinosa Kernel Oil
Sodium Acrylates Copolymer
Hydrolyzed Candida Saitoana Extract
Sodium Stearoyl Glutamate
Albizia Julibrissin Bark Extract
Galactoarabinan
Palmitoyl Tetrapeptide-7
Palmitoyl Oligopeptide
Caprooyl Tetrapeptide-3
Cassia Angustifolia Seed Polysaccharide
Hyaluronic Acid
Oxycoccus Palustris Seed Oil
Rubus Chamaemorus Seed Oil
Withania Somnifera Root Extract
Citrus Aurantium Dulcis Callus Culture Extract
Retinal
Ellagic Acid
Phenyl T-Butylnitrone
Ergothioneine
Glutathione
Mirabilis Jalapa Flower/Leaf/Stem Extract
N-Hydroxysuccinimide
Chrysin
Glutamylamidoethyl Imidazole
Lonicera Caprifolium Flower Extract
Lonicera Japonica Flower Extract
Lavandula Hybrida Oil
Cyclodextrin
Caprylyl Glycol
Steareth-20
Citric Acid
Dextran
Acetyl Tributyl Citrate
Potassium Sorbate
Geraniol
Limonene
Linalool
Water, Glycerin, Caprylic/Capric Triglyceride, Propanediol, Argania Spinosa Kernel Oil, Sodium Acrylates Copolymer, Hydrolyzed Candida Saitoana Extract, Sodium Stearoyl Glutamate, Albizia Julibrissin Bark Extract, Dimethyl Isosorbide, Galactoarabinan, Palmitoyl Tetrapeptide-7, Palmitoyl Oligopeptide, Caprooyl Tetrapeptide-3, Cassia Angustifolia Seed Polysaccharide, Hyaluronic Acid, Oxycoccus Palustris Seed Oil, Rubus Chamaemorus Seed Oil, Niacinamide, Withania Somnifera Root Extract, Citrus Aurantium Dulcis Callus Culture Extract, Retinal, Ellagic Acid, Phenyl T-Butylnitrone, Ergothioneine, Glutathione, Mirabilis Jalapa Flower/Leaf/Stem Extract, N-Hydroxysuccinimide, Chrysin, Glutamylamidoethyl Imidazole, Lonicera Caprifolium Flower Extract, Lonicera Japonica Flower Extract, Lavandula Hybrida Oil, Pentylene Glycol, Butylene Glycol, Cyclodextrin, Caprylyl Glycol, Steareth-20, Citric Acid, Xanthan Gum, Dextran, Acetyl Tributyl Citrate, Potassium Sorbate, Phenoxyethanol, Geraniol, Limonene, Linalool
Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
Dimethyl Isosorbide (often shortened to DMI) is a sugar-derived solvent made from sorbitol. It's used to dissolve tricky ingredients and help them mix smoothly into a formula.
Many actives sit as gritty crystals when undissolved, so DMI swoops in to full dissolve them. This helps improve texture, stability, and how evenly an active is distributed.
It does have a penetration-enhancing reputation that is a bit more nuanced than marketing suggests; a cell study on human skin found that 10% DMI didn't significantly boost the permeation of Hydroquinone, Salicylic Acid, or Octadecenedioic Acid compared to controls (though it did improve their solubility in the formula itself).
Typical usage concentrations usually range from 1-10% depending on the formula's needs; this ingredient is also well tolerated at these levels.
Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Niacinamide is a multitasking form of vitamin B3 that strengthens the skin barrier, reduces pores and dark spots, regulates oil, and improves signs of aging.
And the best part? It's gentle and well-tolerated by most skin types, including sensitive and reactive skin.
You might have heard of "niacin flush", or the reddening of skin that causes itchiness. Niacinamide has not been found to cause this.
In very rare cases, some individuals may not be able to tolerate niacinamide at all or experience an allergic reaction to it.
If you are experiencing flaking, irritation, and dryness with this ingredient, be sure to double check all your products as this ingredient can be found in all categories of skincare.
When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.
When you apply niacinamide to your skin, your body converts it into nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme that is already found in your cells as "fuel" and powers countless biological processes.
In your skin, NAD helps repair cell damage, produce new healthy cells, support collagen production, strengthen the skin barrier, and fight environmental stressors (like UV and pollution).
Our natural NAD levels start to decline with age, leading to slower skin repair, visible aging, and a weaker skin barrier. By providing your skin niacinamide, you're recharging your skin's NAD levels. This leads to stronger, healthier, and younger looking skin.
Another name for vitamin B3 is nicotinamide. This vitamin is water-soluble and our bodies don't store it. We obtain Vitamin B3 from either food or skincare. Meat, fish, wheat, yeast, and leafy greens contain vitamin B3.
The type of niacinamide used in skincare is synthetically created.
Pentylene Glycol (1,2-pentanediol) is a multitasking little diol with three main roles in a formula:
Research on alkanediols (the family pentylene glycol belongs to) show they work by disrupting microbial cell membranes. This disruption helps the primary preservative system in a product work more effectively at lower doses.
On the safety side, the Cosmetic Ingredient Review Expert Panel has concluded this ingredient to be safe as used in current cosmetic practices + concentrations.
Typical use levels in a formula run about 1-5%.
Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).
It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.
On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.
Another perk of this ingredient is that it stays functional across a wide pH range (3-10).
You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.
Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.
Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.
Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.
On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.
Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.