SkinCeuticals A.G.E. Eye Complex Versus SkinMedica TNS® Advanced+ Serum

SkinCeuticals A.G.E. Eye Complex Versus SkinMedica TNS® Advanced+ Serum

This anti-aging eye moisturizer is formulated around Palmitoyl Tetrapeptide-7 to soften the look of wrinkles and fade the look of dark spots.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Glycerin

Dimethicone

Isohexadecane

Paraffin

Propylene Glycol

Silica

Polyglyceryl-4 Isostearate

Cetyl PEG/PPG-10/1 Dimethicone

Hexyl Laurate

Nylon-12

Hydroxypropyl Tetrahydropyrantriol

Methylsilanol/Silicate Crosspolymer

Polyethylene

Ascorbyl Glucoside

Caprylic/Capric Triglyceride

Octyldodecanol

Phenoxyethanol

Tocopheryl Acetate

Ammonium Polyacryloyldimethyl Taurate

PEG-6 Isostearate

Triethanolamine

Sodium Citrate

Methylparaben

Chlorphenesin

Caffeine

Titanium Dioxide

Ethylparaben

Menthoxypropanediol

Vaccinium Myrtillus Fruit Extract

Hesperidin Methyl Chalcone

Pentasodium Pentetate

Aluminum Hydroxide

Stearic Acid

Hesperetin Laurate

N-Hydroxysuccinimide

Dipeptide-2

Palmitoyl Tetrapeptide-7

Palmitoyl Oligopeptide

Chrysin

Water, Glycerin, Dimethicone, Isohexadecane, Paraffin, Propylene Glycol, Silica, Polyglyceryl-4 Isostearate, Cetyl PEG/PPG-10/1 Dimethicone, Hexyl Laurate, Nylon-12, Hydroxypropyl Tetrahydropyrantriol, Methylsilanol/Silicate Crosspolymer, Polyethylene, Ascorbyl Glucoside, Caprylic/Capric Triglyceride, Octyldodecanol, Phenoxyethanol, Tocopheryl Acetate, Ammonium Polyacryloyldimethyl Taurate, PEG-6 Isostearate, Triethanolamine, Sodium Citrate, Methylparaben, Chlorphenesin, Caffeine, Titanium Dioxide, Ethylparaben, Menthoxypropanediol, Vaccinium Myrtillus Fruit Extract, Hesperidin Methyl Chalcone, Pentasodium Pentetate, Aluminum Hydroxide, Stearic Acid, Hesperetin Laurate, N-Hydroxysuccinimide, Dipeptide-2, Palmitoyl Tetrapeptide-7, Palmitoyl Oligopeptide, Chrysin

Pentylene Glycol

Human Neonatal Fibroblast Conditioned Media

Glycereth-7 Triacetate

Shea Butter Ethyl Esters

Ethoxydiglycol

Lactococcus Ferment Lysate

Whey Protein

Chlorella Vulgaris Extract

Saccharide Isomerate

Dimer Tripeptide-43

Vitis Vinifera Flower Cell Extract

Pyrus Malus Fruit Extract

Hydroxyacetophenone

Propanediol

Xanthan Gum

Polyacrylate Crosspolymer-6

Polyacrylate-13

Polyisobutene

Sclerotium Gum

PEG-12 Dimethicone

Lecithin

Pullulan

Butylene Glycol

Polysorbate 20

Aminomethyl Propanol

Disodium EDTA

Ethylhexylglycerin

Water, Pentylene Glycol, Human Neonatal Fibroblast Conditioned Media, Glycereth-7 Triacetate, Shea Butter Ethyl Esters, Glycerin, Ethoxydiglycol, Lactococcus Ferment Lysate, Whey Protein, Chlorella Vulgaris Extract, Saccharide Isomerate, Dimer Tripeptide-43, Vitis Vinifera Flower Cell Extract, Pyrus Malus Fruit Extract, Hydroxyacetophenone, Tocopheryl Acetate, Propanediol, Xanthan Gum, Polyacrylate Crosspolymer-6, Polyacrylate-13, Polyisobutene, Sclerotium Gum, PEG-12 Dimethicone, Lecithin, Pullulan, Butylene Glycol, Sodium Citrate, Polysorbate 20, Aminomethyl Propanol, Disodium EDTA, Phenoxyethanol, Ethylhexylglycerin

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Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Sodium Citrate is the sodium salts of citric acid. In skincare, it is used to alter pH levels and acts as a preservative.

Its main functions are to maintain the pH of a product and neutralize metal ions.

The acidity of our skin is maintained by our glands and skin biome; normal pH level of skin is slightly acidic (~4.75-5.5).

Being slightly acidic allows our skin to create an "acid mantle". This acid mantle is a thin barrier that protects our skin from bacteria and contaminants.

Tocopheryl Acetate is a stable, shelf-friendly form of vitamin E.

Formulators love it because plain vitamin E oxidizes quickly once it hits air. This acetate version stays stable and resists going off, helping to extend a product's shelf life.

It's actually inactive on its own and works like a slow-release "storage" form; the enzymes in your skin called esterases gradually convert it into active vitamin E over time.

One in vivo study showed 5% of the acetate in the living layer of the epidermis converted to vitamin E after 5 days of application. This study also found the skin gained protection against UV damage even though the conversion was slow and small.

Once converted, vitamin E acts as a skin's main fat-soluble antioxidant that fights free radicals to protect skin from damage.

Topical vitamin E generally boosts the skin's photoprotection, and it reduced UV-damage in animal models.

This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.

Overall, it has a pretty solid safety profile and has been found to be non-irritating and non-comedogenic. Allergic reactions may happen but stay rare due to how widely the ingredient gets used.

The concentration will vary depending on the formula; industry data shows 0.1% in baby lotions, 3% in lipsticks, and 5% in foot powders. You can also find this ingredient at 100% in a pure vitamin E oil.

Most leave-on skincare keeps it at the lower end, often between 0.5-1%.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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