Peptide Skincare & BeautySkin science and ingredient guides

Skin science article

Tatcha The Dewy Skin Cream Versus Drunk Elephant Protini Polypeptide Cream

Tatcha The Dewy Skin Cream Versus Drunk Elephant Protini Polypeptide Cream This barrier-repair moisturizer is formulated around Saccharomyces/Rice Ferment Filtrate and Squalane to strengthen the skin barrier and hydrate skin. This anti-aging moisturizer is for

Tatcha The Dewy Skin Cream Versus Drunk Elephant Protini Polypeptide Cream

This barrier-repair moisturizer is formulated around Saccharomyces/Rice Ferment Filtrate and Squalane to strengthen the skin barrier and hydrate skin.

This anti-aging moisturizer is formulated around Sclerocarya Birrea Seed Oil and Sh-Oligopeptide-1 to soften the look of wrinkles and hydrate skin.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Saccharomyces/Rice Ferment Filtrate

Glycerin

Propanediol

Dimethicone

Squalane

Diisostearyl Malate

Behenyl Alcohol

Myristyl Myristate

Dipentaerythrityl Hexahydroxystearate

Bis-Diglyceryl Polyacyladipate-2

Tridecyl Trimellitate

Inositol

Sorbitan Tristearate

Beheneth-20

Camellia Sinensis Leaf Extract

Cladosiphon Okamuranus Extract

Chondrus Crispus Extract

Betaphycus Gelatinum Extract

Oryza Sativa Bran Extract

Panax Ginseng Root Extract

Origanum Majorana Leaf Extract

Thymus Serpyllum Extract

Malva Sylvestris Flower Extract

Sodium Hyaluronate

Gold

Sericin

Phytosteryl Macadamiate

Tocopherol

Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer

Sorbitan Isostearate

Polysorbate 60

Butylene Glycol

Dimethicone/Vinyl Dimethicone Crosspolymer

Sodium Benzoate

Gluconolactone

Ethylhexylglycerin

Parfum

Alcohol

Phenoxyethanol

Citral

Limonene

Linalool

Mica

Tin Oxide

CI 77891

CI 60725

Water, Saccharomyces/Rice Ferment Filtrate, Glycerin, Propanediol, Dimethicone, Squalane, Diisostearyl Malate, Behenyl Alcohol, Myristyl Myristate, Dipentaerythrityl Hexahydroxystearate, Bis-Diglyceryl Polyacyladipate-2, Tridecyl Trimellitate, Inositol, Sorbitan Tristearate, Beheneth-20, Camellia Sinensis Leaf Extract, Cladosiphon Okamuranus Extract, Chondrus Crispus Extract, Betaphycus Gelatinum Extract, Oryza Sativa Bran Extract, Panax Ginseng Root Extract, Origanum Majorana Leaf Extract, Thymus Serpyllum Extract, Malva Sylvestris Flower Extract, Sodium Hyaluronate, Gold, Sericin, Phytosteryl Macadamiate, Tocopherol, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Sorbitan Isostearate, Polysorbate 60, Butylene Glycol, Dimethicone/Vinyl Dimethicone Crosspolymer, Sodium Benzoate, Gluconolactone, Ethylhexylglycerin, Parfum, Alcohol, Phenoxyethanol, Citral, Limonene, Linalool, Mica, Tin Oxide, CI 77891, CI 60725

Dicaprylyl Carbonate

Cetearyl Alcohol

Cetearyl Olivate

Sorbitan Olivate

Sclerocarya Birrea Seed Oil

Bacillus/Folic Acid Ferment Filtrate Extract

Nymphaea Alba Root Extract

Sh-Oligopeptide-1

Sh-Oligopeptide-2

Sh-Polypeptide-1

Sh-Polypeptide-9

Sh-Polypeptide-11

Copper Palmitoyl Heptapeptide-14

Heptapeptide-15 Palmitate

Palmitoyl Tetrapeptide-7

Palmitoyl Tripeptide-1

Alanine

Arginine

Glycine

Histidine

Isoleucine

Phenylalanine

Proline

Serine

Threonine

Valine

Acetyl Glutamine

Coconut Alkanes

Coco-Caprylate/Caprate

Aspartic Acid

Linoleic Acid

Linolenic Acid

Lecithin

Polyvinyl Alcohol

Sodium Lactate

Sodium PCA

PCA

Carbomer

Polysorbate 20

Lactic Acid/Glycolic Acid Copolymer

Xanthan Gum

Isomalt

1,2-Hexanediol

Caprylyl Glycol

Chlorphenesin

Phenylpropanol

Glyceryl Caprylate

Symphytum Officinale Callus Culture Extract

Water, Dicaprylyl Carbonate, Glycerin, Cetearyl Alcohol, Cetearyl Olivate, Sorbitan Olivate, Sclerocarya Birrea Seed Oil, Bacillus/Folic Acid Ferment Filtrate Extract, Nymphaea Alba Root Extract, Sh-Oligopeptide-1, Sh-Oligopeptide-2, Sh-Polypeptide-1, Sh-Polypeptide-9, Sh-Polypeptide-11, Copper Palmitoyl Heptapeptide-14, Heptapeptide-15 Palmitate, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-1, Alanine, Arginine, Glycine, Histidine, Isoleucine, Phenylalanine, Proline, Serine, Threonine, Valine, Acetyl Glutamine, Coconut Alkanes, Coco-Caprylate/Caprate, Sodium Hyaluronate, Aspartic Acid, Linoleic Acid, Linolenic Acid, Lecithin, Butylene Glycol, Polyvinyl Alcohol, Sodium Lactate, Sodium PCA, PCA, Sorbitan Isostearate, Carbomer, Polysorbate 20, Polysorbate 60, Lactic Acid/Glycolic Acid Copolymer, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Xanthan Gum, Isomalt, 1,2-Hexanediol, Caprylyl Glycol, Chlorphenesin, Phenoxyethanol, Tocopherol, Sodium Benzoate, Phenylpropanol, Glyceryl Caprylate, Symphytum Officinale Callus Culture Extract

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

This is a synthetic polymer. It helps improve the texture of products by adding thickness and gel-like feel.

It is also an emulsifer, meaning it prevents ingredients such as oil and water from separating. It also helps evenly disperse other ingredients.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Polysorbate 60 is used to help stabilize products. It is a surfactant and emulsifier. These properties help keep ingredients together in a product. Surfactants help reduce surface tension between ingredients with different states, such as liquids and solids. Emulsifiers help prevent oils and waters from separating.

Polysorbate 60 is sorbitol-based and created from the ethoxylation of sorbitan. Ethoxylation is a chemical reaction used to add ethylene oxide. Sorbitan is a the dehydrated version of sorbitol, a sugar found in fruits.

In this case, the 60 comes from reacting 60 units of ethylene oxide with sorbitan.

Polysorbates are commonly used in medicine and foods.

Sodium Benzoate is a preservative. It's used in both cosmetic and food products to inhibit the growth of mold and bacteria. It is typically produced synthetically.

Both the US FDA and EU Health Committee have approved the use of sodium benzoate. In the US, levels of 0.1% (of the total product) are allowed.

Sodium benzoate works as a preservative by inhibiting the growth of bacteria inside of cells. It prevents the cell from fermenting a type of sugar using an enzyme called phosphofructokinase.

It is the salt of benzoic acid. Foods containing sodium benzoate include soda, salad dressings, condiments, fruit juices, wines, and snack foods.

Studies for using ascorbic acid and sodium benzoate in cosmetics are lacking, especially in skincare routines with multiple steps.

We always recommend speaking with a professional, such as a dermatologist, if you have any concerns.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Sorbitan Isostearate is an emulsifer. It is created from isostearic acid and sorbitol.

As an emulsifier, it keeps the water and oil ingredients from separating. This keeps formulas stable and smooth.

In a 24 hour occlusive patch test on 56 subjects, 10% sorbitan isostearate was completely non-irritating. Most formulas use less than 10%.

Because it's a fatty acid ester, it may not be fungal acne safe since the Malassezia yeast can utilize it as a nutrient source.

Tocopherol is a fat-soluble antioxidant known as Vitamin E.

You'll find this ingredient in the vast majority of skincare (for good reason). It works to neutralize free radicals, or unstable molecules generated by UV exposure, pollution, and other environmental stressors, before they can cause oxidative damage to your skin cells.

Topically applied tocopherol has been shown to protect against UV damage by ramping up the skin's own natural defense enzymes.

It also acts as a skin conditioning agent; some studies show that regular topical use can improve the skin's water-binding capacity over 2-4 weeks.

This ingredient is especially loved for being a team player. When combined with Vitamin C, the photoprotective effect of both ingredients roughly doubles and the combo also helps reduce UV-induced DNA damage.

This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.

In formulations, it also serves as a stabilizer that helps protect other oxidation-prone ingredients from degrading.

Concentrations usually range from 0.1-1% in most leave-on products.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Similar Comparisons

The reference edit

Ingredients, questions
& further reading.

Connected source records selected through this article’s public topic index.

01

Formula cabinet

Ingredients & structured notes

Ingredient index

Ingredients Explained

  1. 01These ingredients are found in both products.
  2. 02Ingredients higher up in an ingredient list are typically present in a larger amount.
  3. 031,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.
  4. 04It is a:
  5. 05Humectant, drawing moisture into the skin
  6. 06Emollient, helping to soften skin
  7. 07Solvent, dispersing and stabilizing formulas
  8. 08Preservative booster, enhancing the antimicrobial activity of other preservatives
  9. 09Alanine is an amino acid and is already found in the human body. Our skin uses alanine to build collagen, elastin, and keratin.
  10. 10Aspartic Acid is an amino acid that our bodies produce naturally. It is an antioxidant.
  11. 11Our body uses Aspartic Acid to help build collagen and elastin. It also plays a role in hydrating skin.
  12. 12Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:
  13. 13Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
  14. 14Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
  15. 15Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.
  16. 16Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.
  17. 17Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).
  18. 18Carbomer is a synthetic thickening and gelling agent. It's basically the ingredient that gives a lot of serums, gels, creams, and sunscreens their smooth, non-sticky texture.
  19. 19Although legally permitted at very high levels, carbomers are normally used at concentrations below 1%.
  20. 20It also needs to be neutralized to actually thicken, and because it is a large molecule, it doesn't really penetrate the skin barrier.
Source · skinsort.com
02

Product index

Related product references

03

Comparison edit

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