Peptide Skincare & BeautySkin science and ingredient guides

Skin science article

The INKEY List Bio-Active Ceramide Repairing and Plumping Moisturizer Versus Derma E Anti Wrinkle Cream

The INKEY List Bio-Active Ceramide Repairing and Plumping Moisturizer Versus Derma E Anti Wrinkle Cream This barrier-repair moisturizer is formulated around Butyrospermum Parkii Butter and Ceramide NP to strengthen the skin barrier and hydrate skin. This anti-

The INKEY List Bio-Active Ceramide Repairing and Plumping Moisturizer Versus Derma E Anti Wrinkle Cream

This barrier-repair moisturizer is formulated around Butyrospermum Parkii Butter and Ceramide NP to strengthen the skin barrier and hydrate skin.

This anti-aging night moisturizer is formulated around Bakuchiol and Retinol to soften the look of wrinkles and refine skin texture.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Glycerin

Butyrospermum Parkii Butter

C12-15 Alkyl Benzoate

Propanediol

Polysilicone-11

C10-18 Triglycerides

Caprylic/Capric Triglyceride

Pentaerythrityl Tetraisostearate

Cetearyl Olivate

Sorbitan Olivate

Cetyl Alcohol

Phenoxyethanol

Ceramide NP

Polyacrylate-13

Hydrogenated Polyisobutene

Ethylhexylglycerin

Polyglyceryl-10 Laurate

Ethylhexyl Palmitate

Laureth-12

Sorbitan Isostearate

Hdi/Trimethylol Hexyllactone Crosspolymer

Polymethylsilsesquioxane

Citric Acid

Sodium Hydroxide

Water, Glycerin, Butyrospermum Parkii Butter, C12-15 Alkyl Benzoate, Propanediol, Polysilicone-11, C10-18 Triglycerides, Caprylic/Capric Triglyceride, Pentaerythrityl Tetraisostearate, Cetearyl Olivate, Sorbitan Olivate, Cetyl Alcohol, Phenoxyethanol, Ceramide NP, Polyacrylate-13, Hydrogenated Polyisobutene, Ethylhexylglycerin, Polyglyceryl-10 Laurate, Ethylhexyl Palmitate, Laureth-12, Sorbitan Isostearate, Hdi/Trimethylol Hexyllactone Crosspolymer, Polymethylsilsesquioxane, Citric Acid, Sodium Hydroxide

Carthamus Tinctorius Seed Oil

Stearic Acid

Glyceryl Stearate Se

Microcrystalline Cellulose

Cellulose Gum

Persea Gratissima Oil

Sesamum Indicum Seed Oil

Helianthus Annuus Seed Oil

Bakuchiol

Retinol

Panthenol

Tocopheryl Acetate

Allantoin

Parfum

Water, Carthamus Tinctorius Seed Oil, Stearic Acid, Glycerin, Glyceryl Stearate Se, Cetyl Alcohol, Microcrystalline Cellulose, Cellulose Gum, Persea Gratissima Oil, Sesamum Indicum Seed Oil, Helianthus Annuus Seed Oil, Bakuchiol, Retinol, Panthenol, Tocopheryl Acetate, Allantoin, Phenoxyethanol, Ethylhexylglycerin, Parfum

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Cetyl Alcohol is a fatty alcohol. Fatty Alcohols are most often used as an emollient or to thicken a product.

Its main roles are:

Though it has "alcohol" in the name, it is not related to denatured alcohol or ethyl alcohol.

The FDA allows products labeled "alcohol-free" to have fatty alcohols.

This ingredient may not be fungal acne safe. It is a primary fatty alcohol with a chain length above 12 carbons. A study from 2019 show Malassezia can feed on fatty alcohols in this range, so it may trigger fungal acne in those prone to it.

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Similar Comparisons

The reference edit

Ingredients, questions
& further reading.

Connected source records selected through this article’s public topic index.

01

Formula cabinet

Ingredients & structured notes

Ingredient index

Ingredients Explained

  1. 01These ingredients are found in both products.
  2. 02Ingredients higher up in an ingredient list are typically present in a larger amount.
  3. 03Caffeine is a naturally occurring plant compound found in coffee beans, tea leaves, cocoa pods, and guarana.
  4. 04As an antioxidant, caffeine protects your skin from free radical damage caused by UV exposure and envionrmnetal stressors.
  5. 05Early research also shows that caffeine can help calm redness, soothe irritated skin, and support hair growth by stimulating microcirculation in the scalp.
  6. 06You might have seen eye creams marketing caffeine as a depuffing ingredient. This is because it is a vasoconstrictor meaning it can temporarily constrict blood vessels, though clinical evidence for this specific use is still limited.
  7. 07Most skincare products contain this ingredient at concentrations between 1-6%. It is able to penetrate skin easily regardless of skin type or thickness.
  8. 08Just so you know, a very small number of case reports describe caffeine-induced allergy. This ingredient is generally well-tolerated, non-irritating, and non-sensitizing for the majority of people.
  9. 09Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
  10. 10Topically, glycerin does several things at once:
  11. 11Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
  12. 12Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
  13. 13This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
  14. 14Just know very high concentrations (>40%) can feel tacky in low humidity.
  15. 15Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
  16. 16Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
  17. 17So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
  18. 18You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Source · skinsort.com
02

Product index

Related product references

03

Comparison edit

Read side by side