The Ordinary Argireline Solution 10% Versus Skin Deva 20% Argireline + Matrixyl 3000 + Hyaluronic Acid Serum

The Ordinary Argireline Solution 10% Versus Skin Deva 20% Argireline + Matrixyl 3000 + Hyaluronic Acid Serum

This anti-aging serum is formulated around Acetyl Hexapeptide-8 to soften the look of wrinkles.

This anti-aging serum is formulated around Acetyl Hexapeptide-8 and Matrixyl 3000 to soften the look of wrinkles and hydrate skin.

What's inside

Key Ingredients

Benefits

Concerns

No concerns

Ingredients Side-by-side

Water

Propanediol

Acetyl Hexapeptide-8

Trisodium Ethylenediamine Disuccinate

Gellan Gum

Sodium Chloride

Isoceteth-20

Dimethyl Isosorbide

Potassium Sorbate

Phenoxyethanol

Chlorphenesin

Water, Propanediol, Acetyl Hexapeptide-8, Trisodium Ethylenediamine Disuccinate, Gellan Gum, Sodium Chloride, Isoceteth-20, Dimethyl Isosorbide, Potassium Sorbate, Phenoxyethanol, Chlorphenesin

Acetyl Hexapeptide-8 20%

Matrixyl 3000

Aloe Barbadensis Leaf Extract

Glycerin

Hyaluronic Acid

Benzyl Alcohol

Dehydroacetic Acid

Water, Acetyl Hexapeptide-8 20%, Matrixyl 3000, Aloe Barbadensis Leaf Extract, Glycerin, Hyaluronic Acid, Benzyl Alcohol, Dehydroacetic Acid

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Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Acetyl Hexapeptide-8 (also known as Argireline) is a synthetic hexapeptide that is often called a "topical Botox alternative".

It works by mimicking how Botox relaxes muscles; it interferes with the signaling process that tells your facial muscles to contract. This can help soften expression lines like forehead wrinkles or crow's feet over time.

The comparison to Botox does have limits because the molecule is water-loving and relatively large.

Acetyl Hexapeptide-8 has a hard time absorbing deeply enough through the skin's outer barrier to actually reach the muscles.

So whether it truly works the way Botox does at a biological level is still up for debate, but early clinical outcomes are fairly encouraging.

A 12 week human study of a multi-ingredient regimen containing this ingredient saw:

While some studies have observed improvements in wrinkle appearance, it is important to note that more consistent results are seen in multi-ingredient formulations (vs just Acetyl Hexapeptide-8 alone).

Some research studies also used higher concentrations (up to 10%) while this ingredient is usually found in concentrations up to 0.005% in leave-on formulations.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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