Skin science article
The Ordinary Argireline Solution 10% Versus Skin Deva Matrixyl 3000 + Hyaluronic Acid Serum
The Ordinary Argireline Solution 10% Versus Skin Deva Matrixyl 3000 + Hyaluronic Acid Serum This anti-aging serum is formulated around Acetyl Hexapeptide-8 to soften the look of wrinkles. This anti-aging serum is formulated around Acetyl Hexapeptide-8 and Palm
The Ordinary Argireline Solution 10% Versus Skin Deva Matrixyl 3000 + Hyaluronic Acid Serum
This anti-aging serum is formulated around Acetyl Hexapeptide-8 to soften the look of wrinkles.
This anti-aging serum is formulated around Acetyl Hexapeptide-8 and Palmitoyl Pentapeptide-4 to soften the look of wrinkles and hydrate skin.
What's inside
Key Ingredients
Benefits
Concerns
No concerns
Ingredients Side-by-side
Water
Propanediol
Acetyl Hexapeptide-8
Trisodium Ethylenediamine Disuccinate
Gellan Gum
Sodium Chloride
Isoceteth-20
Dimethyl Isosorbide
Potassium Sorbate
Phenoxyethanol
Chlorphenesin
Water, Propanediol, Acetyl Hexapeptide-8, Trisodium Ethylenediamine Disuccinate, Gellan Gum, Sodium Chloride, Isoceteth-20, Dimethyl Isosorbide, Potassium Sorbate, Phenoxyethanol, Chlorphenesin
Palmitoyl Pentapeptide-4
Aloe Barbadensis Leaf
Glycerin
Hyaluronic Acid
Benzyl Alcohol
Dehydroacetic Acid
Acetyl Hexapeptide-8, Palmitoyl Pentapeptide-4, Aloe Barbadensis Leaf, Glycerin, Hyaluronic Acid, Benzyl Alcohol, Dehydroacetic Acid
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Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Acetyl Hexapeptide-8 (also known as Argireline) is a synthetic hexapeptide that is often called a "topical Botox alternative".
It works by mimicking how Botox relaxes muscles; it interferes with the signaling process that tells your facial muscles to contract. This can help soften expression lines like forehead wrinkles or crow's feet over time.
The comparison to Botox does have limits because the molecule is water-loving and relatively large.
Acetyl Hexapeptide-8 has a hard time absorbing deeply enough through the skin's outer barrier to actually reach the muscles.
So whether it truly works the way Botox does at a biological level is still up for debate, but early clinical outcomes are fairly encouraging.
A 12 week human study of a multi-ingredient regimen containing this ingredient saw:
While some studies have observed improvements in wrinkle appearance, it is important to note that more consistent results are seen in multi-ingredient formulations (vs just Acetyl Hexapeptide-8 alone).
Some research studies also used higher concentrations (up to 10%) while this ingredient is usually found in concentrations up to 0.005% in leave-on formulations.