Peptide Skincare & BeautySkin science and ingredient guides

Skin science article

Walgreens Hydrating Hyaluronic Acid Serum Versus The Ordinary Hyaluronic Acid 2% + B5

Walgreens Hydrating Hyaluronic Acid Serum Versus The Ordinary Hyaluronic Acid 2% + B5 This hydrating serum is formulated around Panthenol and Sodium Hyaluronate to hydrate skin and strengthen the skin barrier. This hydrating treatment is formulated around Sodi

Walgreens Hydrating Hyaluronic Acid Serum Versus The Ordinary Hyaluronic Acid 2% + B5

This hydrating serum is formulated around Panthenol and Sodium Hyaluronate to hydrate skin and strengthen the skin barrier.

This hydrating treatment is formulated around Sodium Hyaluronate and Sodium Hyaluronate Crosspolymer to hydrate skin and strengthen the skin barrier.

What's inside

Key Ingredients

Benefits

Concerns

No concerns

Ingredients Side-by-side

Water

Cetearyl Alcohol

Glycerin

Cetyl Alcohol

Cetyl Ethylhexanoate

Dimethicone

Glyceryl Stearate

Phenoxyethanol

Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer

Isohexadecane

Propanediol

PEG-100 Stearate

Polyacrylate Crosspolymer-6

Polysorbate 80

Panthenol

Sodium Hyaluronate

Isopropyl Myristate

Ammonium Polyacryloyldimethyl Taurate

Xanthan Gum

Citric Acid

Ethylhexylglycerin

Sorbitan Oleate

Disodium EDTA

Caprylhydroxamic Acid

Niacinamide

Tocopheryl Acetate

T-Butyl Alcohol

Sodium Lauroyl Lactylate

Ceramide NP

Ceramide AP

Phytosphingosine

Cholesterol

Carbomer

Ceramide EOP

Water, Cetearyl Alcohol, Glycerin, Cetyl Alcohol, Cetyl Ethylhexanoate, Dimethicone, Glyceryl Stearate, Phenoxyethanol, Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Isohexadecane, Propanediol, PEG-100 Stearate, Polyacrylate Crosspolymer-6, Polysorbate 80, Panthenol, Sodium Hyaluronate, Isopropyl Myristate, Ammonium Polyacryloyldimethyl Taurate, Xanthan Gum, Citric Acid, Ethylhexylglycerin, Sorbitan Oleate, Disodium EDTA, Caprylhydroxamic Acid, Niacinamide, Tocopheryl Acetate, T-Butyl Alcohol, Sodium Lauroyl Lactylate, Ceramide NP, Ceramide AP, Phytosphingosine, Cholesterol, Carbomer, Ceramide EOP

Pentylene Glycol

Sodium Hyaluronate Crosspolymer

Ahnfeltia Concinna Extract

Trisodium Ethylenediamine Disuccinate

Isoceteth-20

Ethoxydiglycol

Hexylene Glycol

1,2-Hexanediol

Caprylyl Glycol

Water, Sodium Hyaluronate, Pentylene Glycol, Propanediol, Sodium Hyaluronate Crosspolymer, Panthenol, Ahnfeltia Concinna Extract, Glycerin, Trisodium Ethylenediamine Disuccinate, Citric Acid, Isoceteth-20, Ethoxydiglycol, Ethylhexylglycerin, Hexylene Glycol, 1,2-Hexanediol, Phenoxyethanol, Caprylyl Glycol

Reviews

Be the first to review

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Citric Acid is an alpha hydroxy acid (AHA) naturally found in citrus fruits like oranges, lemons, and limes.

Like other AHAs, citric acid can exfoliate skin by breaking down the bonds that hold dead skin cells together. This helps reveal smoother and brighter skin underneath.

However, this exfoliating effect only happens at high concentrations (20%) which can be hard to find in cosmetic products.

Due to this, citric acid is usually included in small amounts as a pH adjuster. This helps keep products slightly more acidic and compatible with skin's natural pH.

In skincare formulas, citric acid can:

While it can provide some skin benefits, research shows lactic acid and glycolic acid are generally more effective and less irritating exfoliants.

Most citric acid used in skincare today is made by fermenting sugars (usually from molasses). This synthetic version is identical to the natural citrus form but easier to stabilize and use in formulations.

Rosacea skin has a lower threshold for acids generally, with 62.5% of rosacea subjects in one study reacting to lactic acid in a sting test. This is why we mark citric acid as a potential rosacea trigger.

However, this ingredient shows up as a pH adjuster or chelator at roughly 0.1-1% in many products. These low levels are unlikely to be an issue for rosacea skin and becomes a potential trigger at exfoliating concentrations (20%). Because everybody's skin is unique, we recommend a patch test if you are unsure.

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Panthenol is a common ingredient that helps hydrate and soothe the skin. It is found naturally in our skin and hair.

There are two forms of panthenol: D and L.

D-panthenol is also known as dexpanthenol. Most cosmetics use dexpanthenol or a mixture of D and L-panthenol.

Panthenol is famous due to its ability to go deeper into the skin's layers. Using this ingredient has numerous pros (and no cons):

Like hyaluronic acid, panthenol is a humectant. Humectants are able to bind and hold large amounts of water to keep skin hydrated.

This ingredient works well for wound healing. It works by increasing tissue in the wound and helps close open wounds.

Once oxidized, panthenol converts to pantothenic acid. Panthothenic acid is found in all living cells.

This ingredient is also referred to as pro-vitamin B5.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Propanediol is an all-star ingredient. It softens, hydrates, and smooths the skin.

It’s often used to:

Propanediol is not likely to cause sensitivity and considered safe to use. It is derived from corn or petroleum with a clear color and no scent.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Similar Comparisons

The reference edit

Ingredients, questions
& further reading.

Connected source records selected through this article’s public topic index.

01

Formula cabinet

Ingredients & structured notes

Ingredient index

Ingredients Explained

  1. 01These ingredients are found in both products.
  2. 02Ingredients higher up in an ingredient list are typically present in a larger amount.
  3. 03Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
  4. 04Topically, glycerin does several things at once:
  5. 05Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
  6. 06Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
  7. 07This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
  8. 08Just know very high concentrations (>40%) can feel tacky in low humidity.
  9. 09Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
  10. 10Hydroxyacetophenone is a small phenolic molecule that earns its place in a formulas as an antioxidant and preservative booster.
  11. 11As a phenol, it is able to neutralize free radicals to protect both the product and the skin from oxidative stress.
  12. 12Though it can't kill microbes on its own, it works as a good supporting agent when combined with other preservatives like Phenoxyethanol or 1,2-Hexanediol.
  13. 13This ingredient naturally occurs as piceol in Norwegian spruce needles (~0.4-1.1% dry weight and in cloudberries). Though the cosmetic-grade material is synthesized for purity and consistency.
  14. 14You'll usually see it used at low levels and suppliers recommend up to 1% added to a water phase.
  15. 15Safety testing was done at concentrations like 0.05% in SPF products and 0.5% in a Human Repeated Insult Patch Test. The safety evidence is assuring; this ingredient is safe for cosmetics in current use and also holds safety status as a food flavori…
  16. 16An honest caveat: the "soothing" and "anti-inflammatory" claims come mostly from supplier marketing rather than published clinical trials. The Cosmetic Ingredient Review's own literature search found no useful efficacy studies on this ingredient.
  17. 17So the antioxidant and preservative-boosting roles are the well supported ones while the calming benefit is plausible but thinly evidenced.
  18. 18Overall, this is a well-tolerated, low-irritation multitasker that quietly helps a formula stay fresh and stable.
  19. 19Tocopherol is a fat-soluble antioxidant known as Vitamin E.
  20. 20You'll find this ingredient in the vast majority of skincare (for good reason). It works to neutralize free radicals, or unstable molecules generated by UV exposure, pollution, and other environmental stressors, before they can cause oxidative damag…
Source · skinsort.com
02

Product index

Related product references

Product

Skin Treats Hyaluronic Acid Serum

Skin Treats Hyaluronic Acid Serum Skin Treats Hyaluronic Acid Serum ingredients explained: Aqua, Propylene Glycol, Glycerin, Sericin, Carboxymethyl Chitosan, Gentiana Scabra Root Extract, P…

Source: incidecoder.comView reference →
03

Comparison edit

Read side by side

04

Ask the journal

Related questions

01Is Serum Good for All Skin Types?

Serums are a form of skincare that can be added to any routine no matter what your skin type is. All skin types can benefit from the use of a serum since there are so many different formulations that can target specific skincare concerns. “Serums are used for hydration,to aid [or] maintain the skin barrier, or treat skin issues like acne or rosacea,” says Dr. Lewis. The type of serum that you may use should depend on the skin issue you’re trying to target. Think of serums as a treatment for the skin. “Some serums can reverse damage and help prevent free radicals that cause the signs of aging skin,” adds Dr. Lewis.

Source · www.skincare.com
02What Skin Types Should Use Hyaluronic Acid?

“Hyaluronic acid is particularly helpful for those experiencing dry skin, and for those desiring a plumping effect,” explains Dr. King. But, if you have an oily skin type, don’t discredit hyaluronic acid from your routine just yet. Despite the excess sebum that you may experience, it’s important to keep your skin hydrated so that it doesn’t overcompensate and produce even more oil as a result. Besides your skin type, you should also look at the condition of your skin to decide if it’s time to begin using hyaluronic acid. “If your skin is starting to look dull, flaky and you’re seeing more pronounced fine lines and wrinkles, that’s a pretty good indication that it’s time to add this ingredient to your routine,” adds O’Conner.

Source · www.skincare.com