Peptide Skincare & BeautySkin science and ingredient guides

Skin science article

Y.O.U Advanced Youth Recharging Peptide Eye Cream Versus Some By Mi Retinol Intense Advanced Triple Action Eye Cream

Y.O.U Advanced Youth Recharging Peptide Eye Cream Versus Some By Mi Retinol Intense Advanced Triple Action Eye Cream This anti-aging eye moisturizer is formulated around Niacinamide and Palmitoyl Tetrapeptide-7 to soften the look of wrinkles. This anti-aging e

Y.O.U Advanced Youth Recharging Peptide Eye Cream Versus Some By Mi Retinol Intense Advanced Triple Action Eye Cream

This anti-aging eye moisturizer is formulated around Niacinamide and Palmitoyl Tetrapeptide-7 to soften the look of wrinkles.

This anti-aging eye moisturizer is formulated around Niacinamide and Retinol to soften the look of wrinkles and fade the look of dark spots.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Cyclopentasiloxane

Diisostearyl Malate

Propanediol

Cetearyl Alcohol

Glycerin

Dipentaerythrityl Hexahydroxystearate

Niacinamide

Cyclohexasiloxane

Glyceryl Stearate

Caprylic/Capric Triglyceride

Butyrospermum Parkii Butter

Aluminum Starch Octenylsuccinate

Poria Cocos Extract

Cetearyl Glucoside

Sorbitan Stearate

PEG-100 Stearate

Propylene Glycol

Potassium Cetyl Phosphate

Dimethicone/Vinyl Dimethicone Crosspolymer

Caffeine

Cyclodextrin

Cucumis Melo Fruit Extract

Polyacrylamide

Phenoxyethanol

Hydroxyacetophenone

C13-14 Isoparaffin

Butylene Glycol

Polysilicone-11

Xanthan Gum

Glycine Soja Seed Extract

Corallina Officinalis Extract

1,2-Hexanediol

Laureth-7

Myrothamnus Flabellifolia Leaf/Stem Extract

Parfum

Disodium EDTA

Polysorbate 20

Pentylene Glycol

Sodium Hyaluronate

Lecithin

Ethylhexylglycerin

Hydrolyzed Vegetable Protein

Triethanolamine

Polyacrylic Acid

Achillea Millefolium Extract

Caprylyl Glycol

Acanthopanax Senticosus Root Extract

Gentiana Scabra Root Extract

Palmitoyl Tetrapeptide-7

Palmitoyl Tripeptide-1

Tocopherol

Sodium Hydroxide

Sodium Lactate

Carbomer

Water, Cyclopentasiloxane, Diisostearyl Malate, Propanediol, Cetearyl Alcohol, Glycerin, Dipentaerythrityl Hexahydroxystearate, Niacinamide, Cyclohexasiloxane, Glyceryl Stearate, Caprylic/Capric Triglyceride, Butyrospermum Parkii Butter, Aluminum Starch Octenylsuccinate, Poria Cocos Extract, Cetearyl Glucoside, Sorbitan Stearate, PEG-100 Stearate, Propylene Glycol, Potassium Cetyl Phosphate, Dimethicone/Vinyl Dimethicone Crosspolymer, Caffeine, Cyclodextrin, Cucumis Melo Fruit Extract, Polyacrylamide, Phenoxyethanol, Hydroxyacetophenone, C13-14 Isoparaffin, Butylene Glycol, Polysilicone-11, Xanthan Gum, Glycine Soja Seed Extract, Corallina Officinalis Extract, 1,2-Hexanediol, Laureth-7, Myrothamnus Flabellifolia Leaf/Stem Extract, Parfum, Disodium EDTA, Polysorbate 20, Pentylene Glycol, Sodium Hyaluronate, Lecithin, Ethylhexylglycerin, Hydrolyzed Vegetable Protein, Triethanolamine, Polyacrylic Acid, Achillea Millefolium Extract, Caprylyl Glycol, Acanthopanax Senticosus Root Extract, Gentiana Scabra Root Extract, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-1, Tocopherol, Sodium Hydroxide, Sodium Lactate, Carbomer

Dimethicone

Polysorbate 60

Methylpropanediol

Cetyl Alcohol

Polymethylsilsesquioxane

Centella Asiatica Extract

Dioscorea Japonica Root Extract

Piper Methysticum Leaf/Root/Stem Extract

Melaleuca Alternifolia Leaf Extract

Panax Ginseng Berry Extract

Artemisia Capillaris Extract

Ganoderma Lucidum Stem Extract

Chlorella Vulgaris Extract

Nymphaea Alba Flower Extract

Elaeis Guineensis Oil

Hydrogenated Lecithin

Panthenol

BHT

Steareth-21

PEG-10 Dimethicone/Vinyl Dimethicone Crosspolymer

Steareth-2

Isohexadecane

Tromethamine

Palmitic Acid

Polyquaternium-51

Stearic Acid

Retinol 0.1%

Glyceryl Caprylate

Tocopheryl Acetate

Polyglyceryl-10 Myristate

PEG-30 Dipolyhydroxystearate

Hydroxyethylcellulose

Glycosyl Trehalose

Beta-Glucan

Glyceryl Polymethacrylate

Hydrogenated Starch Hydrolysate

Adenosine

Raffinose

Dipotassium Glycyrrhizate

BHA

Myristic Acid

Tranexamic Acid

Dipropylene Glycol

Disodium Phosphate

Collagen

Madecassic Acid

Biosaccharide Gum-1

Asiaticoside

Sodium Palmitoyl Proline

Leuconostoc/Radish Root Ferment Filtrate

Asiatic Acid

Glutathione

Retinal

Madecassoside

Sodium Phosphate

Ferulic Acid

Acetyl Hexapeptide-8

Ammonium Acryloyldimethyltaurate/Vp Copolymer

Tetrahydropiperine

Phloretin

Arginine

Water, Glycerin, Caprylic/Capric Triglyceride, Dimethicone, Polysorbate 60, Niacinamide, Methylpropanediol, Cetyl Alcohol, Polymethylsilsesquioxane, Centella Asiatica Extract, Dioscorea Japonica Root Extract, Piper Methysticum Leaf/Root/Stem Extract, Melaleuca Alternifolia Leaf Extract, Panax Ginseng Berry Extract, Artemisia Capillaris Extract, Ganoderma Lucidum Stem Extract, Chlorella Vulgaris Extract, Glycine Soja Seed Extract, Nymphaea Alba Flower Extract, Elaeis Guineensis Oil, Hydrogenated Lecithin, Sodium Hyaluronate, 1,2-Hexanediol, Dimethicone/Vinyl Dimethicone Crosspolymer, Panthenol, BHT, Cyclopentasiloxane, Steareth-21, PEG-10 Dimethicone/Vinyl Dimethicone Crosspolymer, Polyacrylamide, Steareth-2, Isohexadecane, Carbomer, Hydroxyacetophenone, C13-14 Isoparaffin, Tromethamine, Palmitic Acid, Polyquaternium-51, Stearic Acid, Polysorbate 20, Retinol 0.1%, Ethylhexylglycerin, Glyceryl Caprylate, Tocopheryl Acetate, Polyglyceryl-10 Myristate, PEG-30 Dipolyhydroxystearate, Hydroxyethylcellulose, Glycosyl Trehalose, Beta-Glucan, Glyceryl Polymethacrylate, Laureth-7, Butylene Glycol, Disodium EDTA, Hydrogenated Starch Hydrolysate, Adenosine, Raffinose, Dipotassium Glycyrrhizate, Lecithin, Tocopherol, Pentylene Glycol, BHA, Myristic Acid, Tranexamic Acid, Propanediol, Dipropylene Glycol, Disodium Phosphate, Caprylyl Glycol, Collagen, Madecassic Acid, Biosaccharide Gum-1, Asiaticoside, Sodium Palmitoyl Proline, Leuconostoc/Radish Root Ferment Filtrate, Asiatic Acid, Glutathione, Retinal, Madecassoside, Sodium Phosphate, Ferulic Acid, Acetyl Hexapeptide-8, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Tetrahydropiperine, Phloretin, Arginine, Parfum

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Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.

It is a:

Humectant, drawing moisture into the skin

Emollient, helping to soften skin

Solvent, dispersing and stabilizing formulas

Preservative booster, enhancing the antimicrobial activity of other preservatives

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

C13-14 Isoparaffin is a synthetic emollient, solvent, and thickening agent. It helps soften skin and improves spreadability without leaving a greasy residue.

This ingredient has been found to be non-sensitizing and safe for use in cosmetics.

Two things floating around online that cause fear-mongering:

There's one scary-sounding study related to kidney tumors in male rats; this depends on a protein called alpha-2u-globulin that binds the ingredient and clogs up kidney cells. Female rats barely make this protein, and humans don't make it at all so this effect cannot happen to us. Regulatory bodies have states this rat-only pathway shouldn't be used to judge human risk.

The other thing you'll see is 1,4-dioxane being a trace byproduct that can form during manufacturing of petroleum-derived ingredients. This is a real, but heavily managed/monitored issue. This byproduct is removed through purification steps before the ingredients goes into the formula. Regulatory bodies also actively monitor residual levels for safety.

One last thing to note: this ingredient is a pure hydrocarbon with no fatty-acid or ester chains for Malassezia to feed on, so it's considered fungal acne safe.

Caprylic/Capric Triglyceride (aka MCT Oil) is a lightweight emollient, solvent, and texture enhancer. It is considered a skin-softener by helping to prevent moisture loss.

Though it behaves like an oil, it is not technically one due to its chemical composition. One perk of this ingredient is that it is very stable, resistant to oxidation, and unlikely to go rancid.

In practice, that translates to a long shelf life and a consistently elegant skin feel.

While there is an assumption Caprylic Triglyceride can clog pores due to it being derived from coconut oil, there is no research supporting this. Just patch test if you have concerns.

Fractionated coconut oil and MCT Oil are both listed as Caprylic/Capric Triglyceride according to INCI. This is because INCI names are based on the ingredient’s final chemical composition and not its marketing name or source.

This ingredient is treated as the gold standard fungal acne safe oil. Even though it is coconut derived, the problematic lauric acid is stripped out.

This leaves just caprylic (C8) and capric (C10) acid. These chain lengths actually trend antifungal; a 2020 study found caprylic acid was enough to disrupt Malassezia furfur cell membrane, with a caprylic acid derivative damaging membrane structures at concentrations as low as 0.2%.

Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.

Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.

Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).

Carbomer is a synthetic thickening and gelling agent. It's basically the ingredient that gives a lot of serums, gels, creams, and sunscreens their smooth, non-sticky texture.

Although legally permitted at very high levels, carbomers are normally used at concentrations below 1%.

It also needs to be neutralized to actually thicken, and because it is a large molecule, it doesn't really penetrate the skin barrier.

Allergy-wise, the risk is very low. Clinical studies show carbomers have low potential for skin irritation/sensitization even at concentrations up to 100%.

A 2024 UK study patch-tested 1,302 patients and found true allergy to the parent group of carbomer to be rare with no confirmed relevant reactions.

Cyclopentasiloxane (D5) is a lightweight silicone that mostly acts as an emollient and solvent in cosmetics. Its the reason your products feel silky, fast-spreading, and non-greasy.

Since D5 is volatile, it does its thing and then evaporates off the skin quickly.

The safety profile of this ingredient is reassuring; the US CIR Expert Panel concluded D5 is safe as used in cosmetics and Health Canada concluded that D5 is not harmful to human health or the environment as currently used in cosmetics

There's a study that people mention about D5 in a rat study showing tumors. This study is related to long-term inhalation of high D5 levels.

Regulatory bodies have judged this study to be not applicable in topical skincare since skin absorption of D5 is very low and we're not really inhaling huge amounts of D5.

The only restriction for this ingredient is environmental. The European Chemicals Agency (ECHA) restricted D5 in wash-off cosmetics at or above 0.1% due to their persistence in water.

This ingredient is a silicone elastomer that works as a texture enhancer, adds a silky slip, and also helps absorb excess oil.

Because it's a large macromolecule that's insoluble in water and chemically inert, it's not expected to penetrate or be absorbed into skin.

Human patch tests with a facial lotion containing 1% of this ingredient found no sensitization.

Disodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air.

This ingredient mainly works behind the scenes and helps with:

On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it.

One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin).

Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption.

You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%.

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Glycine Soja Seed Extract comes from the seed of the wild soybean plant. Wild soybean extract contains fatty acids (linoleic, oleic, linolenic), vitamin E, and antioxidants.

The wild soybean contains soyasaponins, a bioactive compound. Soyasaponins have inflammatory, antimutagenic, anticarcinogenic, antimicrobial properties. Soyasaponin has also been found to inhibit the melanin-creation process.

Two powerful components found in the wild soybean include genistein and diadzein. These two isoflavones are potent antioxidants with anti-inflammatory properties. Genistein in particular has been found to prevent redness caused by UV exposure.

One study from South Korea found wild soybean extract to help promote hair growth at the cellular level.

The wild soybean plant is a cousin to the famous soybean that gives us tofu, soy milk, and soy sauce.

Hydroxyacetophenone is a small phenolic molecule that earns its place in a formulas as an antioxidant and preservative booster.

As a phenol, it is able to neutralize free radicals to protect both the product and the skin from oxidative stress.

Though it can't kill microbes on its own, it works as a good supporting agent when combined with other preservatives like Phenoxyethanol or 1,2-Hexanediol.

This ingredient naturally occurs as piceol in Norwegian spruce needles (~0.4-1.1% dry weight and in cloudberries). Though the cosmetic-grade material is synthesized for purity and consistency.

You'll usually see it used at low levels and suppliers recommend up to 1% added to a water phase.

Safety testing was done at concentrations like 0.05% in SPF products and 0.5% in a Human Repeated Insult Patch Test. The safety evidence is assuring; this ingredient is safe for cosmetics in current use and also holds safety status as a food flavoring as well.

An honest caveat: the "soothing" and "anti-inflammatory" claims come mostly from supplier marketing rather than published clinical trials. The Cosmetic Ingredient Review's own literature search found no useful efficacy studies on this ingredient.

So the antioxidant and preservative-boosting roles are the well supported ones while the calming benefit is plausible but thinly evidenced.

Overall, this is a well-tolerated, low-irritation multitasker that quietly helps a formula stay fresh and stable.

Laureth-7 is created by the ethoxylation of lauryl alcohol using ethylene oxide. Lauryl alcohol is a fatty alcohol with hydrating properties.

This ingredient is an emulsifier and cleansing ingredient. As an emulsifier, it is used to prevent ingredients from separating. It also helps cleanse the skin by gathering dirt, oil, and pollutants to be rinsed away.

Lecithin is a term for a group of substances found in the cell membranes of plants, animals, and humans. They are made up of phospholipids.

Thanks to its amphiphilic structure (water-loving head and oil-loving tail), it is a true multitasker:

It plays well with most ingredients and is typically used at 0.1-1%. However, concentrations up to 50% have been reported in moisturizers.

Niacinamide is a multitasking form of vitamin B3 that strengthens the skin barrier, reduces pores and dark spots, regulates oil, and improves signs of aging.

And the best part? It's gentle and well-tolerated by most skin types, including sensitive and reactive skin.

You might have heard of "niacin flush", or the reddening of skin that causes itchiness. Niacinamide has not been found to cause this.

In very rare cases, some individuals may not be able to tolerate niacinamide at all or experience an allergic reaction to it.

If you are experiencing flaking, irritation, and dryness with this ingredient, be sure to double check all your products as this ingredient can be found in all categories of skincare.

When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.

When you apply niacinamide to your skin, your body converts it into nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme that is already found in your cells as "fuel" and powers countless biological processes.

In your skin, NAD helps repair cell damage, produce new healthy cells, support collagen production, strengthen the skin barrier, and fight environmental stressors (like UV and pollution).

Our natural NAD levels start to decline with age, leading to slower skin repair, visible aging, and a weaker skin barrier. By providing your skin niacinamide, you're recharging your skin's NAD levels. This leads to stronger, healthier, and younger looking skin.

Another name for vitamin B3 is nicotinamide. This vitamin is water-soluble and our bodies don't store it. We obtain Vitamin B3 from either food or skincare. Meat, fish, wheat, yeast, and leafy greens contain vitamin B3.

The type of niacinamide used in skincare is synthetically created.

Parfum is a catch-all term for an ingredient or more that is used to give a scent to products.

Also called "fragrance", this ingredient can be a blend of hundreds of chemicals or plant oils. This means every product with "fragrance" or "parfum" in the ingredients list is a different mixture.

For instance, Habanolide is a proprietary trade name for a specific aroma chemical. When used as a fragrance ingredient in cosmetics, most aroma chemicals fall under the broad labeling category of “FRAGRANCE” or “PARFUM” according to EU and US regulations.

The term 'parfum' or 'fragrance' is not regulated in many countries. In many cases, it is up to the brand to define this term.

For instance, many brands choose to label themselves as "fragrance-free" because they are not using synthetic fragrances. However, their products may still contain ingredients such as essential oils that are considered a fragrance by INCI standards.

One example is Calendula flower extract. Calendula is an essential oil that still imparts a scent or 'fragrance'.

Depending on the blend, the ingredients in the mixture can cause allergies and sensitivities on the skin. Some ingredients that are known EU allergens include linalool and citronellol.

Parfum can also be used to mask or cover an unpleasant scent.

The bottom line is: not all fragrances/parfum/ingredients are created equally. If you are worried about fragrances, we recommend taking a closer look at an ingredient. And of course, we always recommend speaking with a professional.

Pentylene Glycol (1,2-pentanediol) is a multitasking little diol with three main roles in a formula:

Research on alkanediols (the family pentylene glycol belongs to) show they work by disrupting microbial cell membranes. This disruption helps the primary preservative system in a product work more effectively at lower doses.

On the safety side, the Cosmetic Ingredient Review Expert Panel has concluded this ingredient to be safe as used in current cosmetic practices + concentrations.

Typical use levels in a formula run about 1-5%.

Polyacrylamide is a synthetic polymer. It is used to stabilize products and bind ingredients. When hydrated, Polyacrylamide forms a soft gel.

Polyacrylamide is low-toxicity. If source properly, it is deemed safe to use in cosmetics.

It should be noted the precursor to Polyacrylamide is acrylamide. Acrylamide is a carcinogen. Most reputable sources of Polyacrylamide will screen for residual acrylamide to make sure the count is in a safe range. Acrylamide is not able to be absorbed through the skin.

We recommend speaking with a professional if you have concerns.

Polysorbate 20 is a gentle, water-soluble emulsifier and mild surfactant. It stops oil and water from separating to keep your formulas blended and stable.

It also acts as a mild penetration enhancer by helping active ingredients absorb slightly better.

The common safety discussion around this ingredient involves a manufacturing byproduct called 1,4-dioxane.

Trace amounts can form during production but the EU's Scientific Committee on Consumer Safety has concluded that levels at/below 10 ppm in finished products are safe (commercial products consistently fall within acceptable margins).

True allergic reactions are uncommon and the CIR Expert Panel has confirmed this ingredient to be safe as used in cosmetics.

Because it is derived from lauric acid, it may not be fungal acne safe.

Propanediol is an all-star ingredient. It softens, hydrates, and smooths the skin.

It’s often used to:

Propanediol is not likely to cause sensitivity and considered safe to use. It is derived from corn or petroleum with a clear color and no scent.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Tocopherol is a fat-soluble antioxidant known as Vitamin E.

You'll find this ingredient in the vast majority of skincare (for good reason). It works to neutralize free radicals, or unstable molecules generated by UV exposure, pollution, and other environmental stressors, before they can cause oxidative damage to your skin cells.

Topically applied tocopherol has been shown to protect against UV damage by ramping up the skin's own natural defense enzymes.

It also acts as a skin conditioning agent; some studies show that regular topical use can improve the skin's water-binding capacity over 2-4 weeks.

This ingredient is especially loved for being a team player. When combined with Vitamin C, the photoprotective effect of both ingredients roughly doubles and the combo also helps reduce UV-induced DNA damage.

This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.

In formulations, it also serves as a stabilizer that helps protect other oxidation-prone ingredients from degrading.

Concentrations usually range from 0.1-1% in most leave-on products.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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The reference edit

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& further reading.

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03

Comparison edit

Read side by side