Peptide Skincare & BeautySkin science and ingredient guides

Ingredient or product comparison

Creamy Retinol Versus Principia Sérum Facial PM-10

Creamy Retinol Versus Principia Sérum Facial PM-10 Detailed comparison of Creamy Retinol versus Principia Sérum Facial PM-10. This anti-aging serum is formulated around Retinol and Alpha-Arbutin to soften the look of wrinkles and fade the look of dark spots. T

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Creamy Retinol Versus Principia Sérum Facial PM-10 Detailed comparison of Creamy Retinol versus Principia Sérum Facial PM-10. This anti-aging serum is formulated around Retinol and Alpha-Arbutin to soften the look of wrinkles and fade the look of dark spots. This anti-aging serum is formulated around Palmitoyl Tripeptide-1 and Palmitoyl Tetrapeptide-7 to soften the look of wrinkles and refine skin texture. Water Retinol Alpha-Arbutin Butylene Glycol Ascorbyl Palmitate Sodium Hyaluronate Sodium Acrylates Copolymer Xanthan Gum Glycerin Linoleic Acid Lecithin Linolenic Acid Arachidonic Acid Azelamidopropyl Dimethyl Amine Palmitoyl Tripeptide-1 Palmitoyl Hexapeptide-12 Hydroxyethylcellulose Phloretin Tocopherol Ferulic Acid BHA BHT Ethoxydiglycol Disodium EDTA Bisabolol Polysorbate 80 Dehydroacetic Acid Benzoic Acid Polysorbate 20 Benzyl Alcohol Phenoxyethanol Poloxamer 407 Ethylhexylglycerin Water, Retinol, Alpha-Arbutin, Butylene Glycol, Ascorbyl Palmitate, Sodium Hyaluronate, Sodium Acrylates Copolymer, Xanthan Gum, Glycerin, Linoleic Acid, Lecithin, Linolenic Acid, Arachidonic Acid, Azelamidopropyl Dimethyl Amine, Palmitoyl Tripeptide-1, Palmitoyl Hexapeptide-12, Hydroxyethylcellulose, Phloretin, Tocopherol, Ferulic Acid, BHA, BHT, Ethoxydiglycol, Disodium EDTA, Bisabolol, Polysorbate 80, Dehydroacetic Acid, Benzoic Acid, Polysorbate 20, Benzyl Alcohol, Phenoxyethanol, Poloxamer 407, Ethylhexylglycerin Carbomer Palmitoyl Tetrapeptide-7 Hydroxypropyl Cyclodextrin Palmitoyl Tripeptide-38 Propylene Glycol Caprylyl Glycol Sodium Hydroxide Water, Glycerin, Sodium Hyaluronate, Butylene Glycol, Carbomer, Polysorbate 20, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Hydroxypropyl Cyclodextrin, Palmitoyl Tripeptide-38, Propylene Glycol, Phenoxyethanol, Caprylyl Glycol, Xanthan Gum, Disodium EDTA, Sodium Hydroxide Be the first to review These ingredients are found in both products. Ingredients higher up in an ingredient list are typically present in a larger amount. Butylene Glycol (or BG) is used within cosmetic products for a few different reasons: Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients. Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness. Disodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air. This ingredient mainly works behind the scenes and helps with: On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it. One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin). Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption. You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%. Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum. Topically, glycerin does several things at once: Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3. Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin. This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products. Just know very high concentrations (>40%) can feel tacky in low humidity. Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine. Palmitoyl Tripeptide-1 (aka Pal-GHK) is a synthetic signal peptide made of three amino acids attached to palmitic acid. That fatty acid attachment is the key: it boosts the peptide's ability to penetrate the skin barrier. This puts it closer to the dermal cells where it can actually make a difference. Once there, it acts as a matrikine, a signaling peptide that prompts fibroblasts to produce more collagen, fibronectin, and hyaluronic acid. In vitro studies show it can boost collagen production in skin cells even when UV-damaged skin samples were treated with it at a tiny concentration (it almost fully restored dermal collagen at 5ppm). It achieved this at 100x lower concentration than retinoic acid, which needed 500 ppm to do the s