Peptide Skincare & BeautySkin science and ingredient guides

Ingredient or product comparison

Genabelle PDRN Rejuvenating Toner Versus MediCube PDRN Pink Glutathione Serum Mist

Genabelle PDRN Rejuvenating Toner Versus MediCube PDRN Pink Glutathione Serum Mist Detailed comparison of Genabelle PDRN Rejuvenating Toner versus MediCube PDRN Pink Glutathione Serum Mist. This anti-aging toner is formulated around Niacinamide and Panthenol t

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Genabelle PDRN Rejuvenating Toner Versus MediCube PDRN Pink Glutathione Serum Mist Detailed comparison of Genabelle PDRN Rejuvenating Toner versus MediCube PDRN Pink Glutathione Serum Mist. This anti-aging toner is formulated around Niacinamide and Panthenol to soften the look of wrinkles and strengthen the skin barrier. This anti-aging serum is formulated around Sodium DNA and Glutathione to soften the look of wrinkles and brighten dull-looking skin. Water Butylene Glycol Glycerin Propanediol Niacinamide Dipropylene Glycol 1,2-Hexanediol Panthenol Sodium DNA Citric Acid Ethylhexylglycerin Adenosine Xanthan Gum Sodium Citrate Disodium EDTA Sodium Hyaluronate Portulaca Oleracea Extract Centella Asiatica Extract Hydrolyzed Vegetable Protein Maltodextrin Beta-Glucan Tocopherol Hyaluronic Acid Hydrolyzed Sodium DNA Hydroxypropyltrimonium Hyaluronate Madecassoside Hydrolyzed Hyaluronic Acid Tripeptide-1 Sodium Acetylated Hyaluronate Sodium Hyaluronate Crosspolymer Madecassic Acid Hydrolyzed Sodium Hyaluronate Asiatic Acid Asiaticoside Acetyl Hexapeptide-8 Potassium Hyaluronate Water, Butylene Glycol, Glycerin, Propanediol, Niacinamide, Dipropylene Glycol, 1,2-Hexanediol, Panthenol, Sodium DNA, Citric Acid, Ethylhexylglycerin, Adenosine, Xanthan Gum, Sodium Citrate, Disodium EDTA, Sodium Hyaluronate, Portulaca Oleracea Extract, Centella Asiatica Extract, Hydrolyzed Vegetable Protein, Maltodextrin, Beta-Glucan, Tocopherol, Hyaluronic Acid, Hydrolyzed Sodium DNA, Hydroxypropyltrimonium Hyaluronate, Madecassoside, Hydrolyzed Hyaluronic Acid, Tripeptide-1, Sodium Acetylated Hyaluronate, Sodium Hyaluronate Crosspolymer, Madecassic Acid, Hydrolyzed Sodium Hyaluronate, Asiatic Acid, Asiaticoside, Acetyl Hexapeptide-8, Potassium Hyaluronate Collagen Water C13-15 Alkane Ricinus Communis Seed Oil Glycereth-26 Sodium Chloride Sorbitol Hydroxyethyl Urea Helianthus Annuus Seed Oil Parfum Eclipta Prostrata Extract Melia Azadirachta Leaf Extract Glutathione Paeonia Lactiflora Root Extract Moringa Oleifera Seed Oil Candida Bombicola/Glucose/Methyl Rapeseedate Ferment Rosa Damascena Flower Water Biotin Hexapeptide-2 Biotinoyl Tripeptide-1 Tripeptide-3 Myristoyl Pentapeptide-17 Hexapeptide-9 Water, Collagen Water, Dipropylene Glycol, C13-15 Alkane, Ricinus Communis Seed Oil, Glycereth-26, 1,2-Hexanediol, Niacinamide, Sodium Chloride, Sorbitol, Hydroxyethyl Urea, Butylene Glycol, Helianthus Annuus Seed Oil, Parfum, Ethylhexylglycerin, Eclipta Prostrata Extract, Adenosine, Sodium DNA, Melia Azadirachta Leaf Extract, Glutathione, Paeonia Lactiflora Root Extract, Moringa Oleifera Seed Oil, Candida Bombicola/Glucose/Methyl Rapeseedate Ferment, Rosa Damascena Flower Water, Biotin, Hexapeptide-2, Biotinoyl Tripeptide-1, Acetyl Hexapeptide-8, Tripeptide-1, Tripeptide-3, Myristoyl Pentapeptide-17, Hexapeptide-9 These ingredients are found in both products. Ingredients higher up in an ingredient list are typically present in a larger amount. 1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse. It is a: Humectant, drawing moisture into the skin Emollient, helping to soften skin Solvent, dispersing and stabilizing formulas Preservative booster, enhancing the antimicrobial activity of other preservatives Acetyl Hexapeptide-8 (also known as Argireline) is a synthetic hexapeptide that is often called a "topical Botox alternative". It works by mimicking how Botox relaxes muscles; it interferes with the signaling process that tells your facial muscles to contract. This can help soften expression lines like forehead wrinkles or crow's feet over time. The comparison to Botox does have limits because the molecule is water-loving and relatively large. Acetyl Hexapeptide-8 has a hard time absorbing deeply enough through the skin's outer barrier to actually reach the muscles. So whether it truly works the way Botox does at a biological level is still up for debate, but early clinical outcomes are fairly encouraging. A 12 week human study of a multi-ingredient regimen containing this ingredient saw: While some studies have observed improvements in wrinkle appearance, it is important to note that more consistent results are seen in multi-ingredient formulations (vs just Acetyl Hexapeptide-8 alone). Some research studies also used higher concentrations (up to 10%) while this ingredient is usually found in concentrations up to 0.005% in leave-on formulations. Adenosine is a purine nucleoside that your body already makes in every cell. In skincare, it acts mainly as a skin conditioning and anti-aging agent. The way it works is fairly well mapped out: Your skin has cells called fibroblasts that build collagen (the stuff that keeps skin firm and smooth). Adenosine basically flips a switch on these cells that tells them to get to work making more collagen and other proteins. These cells slow down on their own as skin ages, so Adenosine helps give them a little nudge to keep going. The clinical backing is pretty solid too. A blind, randomized, placebo-controlled trial of 126 women aged 45-65 tested a 0.1% cream twice daily and found real improvements in crow's feet and frown lines using a precise 3D skin-mapping technique; these changes showed up by week 3 and held at 2 months. A later study using Adenosine-loaded dissolving microneedle patches reported gains in wrinkle depth, dermal density, elasticity, and hydration. On concentrations, South Korea's Ministry of Food and Drug Safety has set 0.04% as the approved functional anti-wrinkle level. You'll typically see this ingredient used somewhere in the 0.04-0.1% range since it works at low doses. This ingredient has been found safe for cosmetics with the data showing no irritation or sensitization. Overall, this is a great ingredient for any anti-aging routine and has no photosensitizing effect, so it