Peptide Skincare & BeautySkin science and ingredient guides

Ingredient or product comparison

GHK-Cu Protocol Dosage Timing: Formulation Comparison

Water-based serum 1–3% GHK-Cu Morning + evening on damp skin Epidermis + upper dermis 90 days refrigerated Best bioavailability but requires immediate refrigeration after opening. Peptide degrades in aqueous solution at room temperature Anhydrous oil suspensio

This source-based comparison does not add ratings or recommend a winner.

  • Water-based serum
  • 1–3% GHK-Cu
  • Morning + evening on damp skin
  • Epidermis + upper dermis
  • 90 days refrigerated
  • Best bioavailability but requires immediate refrigeration after opening. Peptide degrades in aqueous solution at room temperature
  • Anhydrous oil suspension
  • 0.5–2% GHK-Cu
  • Evening only (occlusive)
  • Epidermis primarily
  • 12 months at room temp
  • Longest shelf stability but slower penetration. Copper release delayed by lipid carrier matrix
  • Liposomal encapsulation
  • Morning preferred
  • Deep dermis
  • 6 months refrigerated
  • Highest dermal penetration due to phospholipid carrier. Expensive but most effective for photoaging reversal
  • Cream emulsion
  • 1–2% GHK-Cu
  • Morning or evening
  • Upper dermis
  • 6 months at room temp
  • Mid-range option. Easier to formulate at home but emulsifiers may compete for copper binding