Ingredient or product comparison
Head-to-Head Research Comparisons in 3D Skin Models
In 3D reconstructed human epidermis (EpiDerm, MatTek), UV-B challenge (100 mJ/cm²), 24h post-irradiation assessment: MT-2 pre-treatment (10nM, 72h): melanin content +68% (Fontana-Masson), CPD+ cells −38% (IHC), TEWL +28% versus +48% in UV+vehicle — indicating
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- In 3D reconstructed human epidermis (EpiDerm, MatTek), UV-B challenge (100 mJ/cm²), 24h post-irradiation assessment: MT-2 pre-treatment (10nM, 72h): melanin content +68% (Fontana-Masson), CPD+ cells −38% (IHC), TEWL +28% versus +48% in UV+vehicle — indicating improved barrier function through pigment-mediated UV attenuation. GHK-Cu treatment (10µg/mL, 24h post-UV): MMP-1 in conditioned medium −38-44%, procollagen I PICP +28-34%, IL-8 −22-28%, TNF-α −18-24% — indicating collagen matrix protection and anti-inflammatory action post-UV.
- In combination (MT-2 pre-treatment + GHK-Cu post-UV): CPD+ cells −52% (greater than either alone, −38% MT-2 and −28% GHK-Cu via DNA repair alone), procollagen I PICP +38% (greater than GHK-Cu alone +28%, with MT-2 contributing paracrine keratinocyte-fibroblast MITF-driven bFGF), TEWL +18% versus +48% UV vehicle (best barrier preservation). This additive/synergistic profile supports the mechanistic complementarity of MC1R eumelanin photoprotection + Nrf2/NER/collagen preservation being non-redundant research endpoints.