Peptide Skincare & BeautySkin science and ingredient guides

Ingredient or product comparison

Lancôme Advanced Génifique Night Cream Versus Lancôme Rénergie H.P.N. 300-Peptide Cream

Lancôme Advanced Génifique Night Cream Versus Lancôme Rénergie H.P.N. 300-Peptide Cream Detailed comparison of Lancôme Advanced Génifique Night Cream versus Lancôme Rénergie H.P.N. 300-Peptide Cream. This barrier-repair night moisturizer is formulated around B

This source-based comparison does not add ratings or recommend a winner.

Lancôme Advanced Génifique Night Cream Versus Lancôme Rénergie H.P.N. 300-Peptide Cream Detailed comparison of Lancôme Advanced Génifique Night Cream versus Lancôme Rénergie H.P.N. 300-Peptide Cream. This barrier-repair night moisturizer is formulated around Bifida Ferment Lysate and Ceramide NP to strengthen the skin barrier and soften the look of wrinkles. This anti-aging moisturizer is formulated around Niacinamide and Adenosine to soften the look of wrinkles and refine skin texture. Water Bifida Ferment Lysate Glycerin Dicaprylyl Ether Pentylene Glycol Polyglyceryl-6 Distearate Propanediol Cetyl Esters Jojoba Esters Ammonium Polyacryloyldimethyl Taurate Behenyl Alcohol Octyldodecanol Acacia Decurrens Flower Wax Helianthus Annuus Seed Wax Helianthus Annuus Seed Oil Polymnia Sonchifolia Root Juice Ceramide NP Alpha-Glucan Oligosaccharide Sodium Hyaluronate Sodium Hydroxide Sodium Stearoyl Glutamate Salicyloyl Phytosphingosine 2-Oleamido-1,3-Octadecanediol Adenosine Mannose Coco-Caprylate/Caprate Ascorbyl Glucoside Hydroxyacetophenone Hydroxypalmitoyl Sphinganine Hydroxypropyl Starch Phosphate Capryloyl Salicylic Acid Trisodium Ethylenediamine Disuccinate Lactic Acid Lactobacillus Acetic Acid Maltodextrin Faex Extract Polyglycerin-3 Polyglyceryl-3 Beeswax Cetyl Alcohol Tocopherol Sodium Benzoate Linalool Limonene Citronellol Parfum Water, Bifida Ferment Lysate, Glycerin, Dicaprylyl Ether, Pentylene Glycol, Polyglyceryl-6 Distearate, Propanediol, Cetyl Esters, Jojoba Esters, Ammonium Polyacryloyldimethyl Taurate, Behenyl Alcohol, Octyldodecanol, Acacia Decurrens Flower Wax, Helianthus Annuus Seed Wax, Helianthus Annuus Seed Oil, Polymnia Sonchifolia Root Juice, Ceramide NP, Alpha-Glucan Oligosaccharide, Sodium Hyaluronate, Sodium Hydroxide, Sodium Stearoyl Glutamate, Salicyloyl Phytosphingosine, 2-Oleamido-1,3-Octadecanediol, Adenosine, Mannose, Coco-Caprylate/Caprate, Ascorbyl Glucoside, Hydroxyacetophenone, Hydroxypalmitoyl Sphinganine, Hydroxypropyl Starch Phosphate, Capryloyl Salicylic Acid, Trisodium Ethylenediamine Disuccinate, Lactic Acid, Lactobacillus, Acetic Acid, Maltodextrin, Faex Extract, Polyglycerin-3, Polyglyceryl-3 Beeswax, Cetyl Alcohol, Tocopherol, Sodium Benzoate, Linalool, Limonene, Citronellol, Parfum Dimethicone Cetearyl Alcohol Theobroma Grandiflorum Seed Butter Alcohol Denat. Cetearyl Isononanoate Niacinamide Glyceryl Stearate PEG-100 Stearate Isopropyl Palmitate Cyclodextrin Hydrolyzed Lupine Protein Pisum Sativum Extract Hydrolyzed Hyaluronic Acid Hydrolyzed Linseed Extract Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate Tocopheryl Acetate Cera Alba Orbignya Oleifera Seed Oil Simmondsia Chinensis Butter Cetearyl Glucoside Citric Acid Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer Polysorbate 60 Potassium Cetyl Phosphate Sorbitan Isostearate Dimethicone/Polyglycerin-3 Crosspolymer Benzyl Alcohol Geraniol Chlorphenesin Dipropylene Glycol Phenoxyethanol Water, Glycerin, Dimethicone, Cetearyl Alcohol, Theobroma Grandiflorum Seed Butter, Alcohol Denat., Cetearyl Isononanoate, Niacinamide, Glyceryl Stearate, PEG-100 Stearate, Isopropyl Palmitate, Octyldodecanol, Cyclodextrin, Hydrolyzed Lupine Protein, Pisum Sativum Extract, Adenosine, Capryloyl Salicylic Acid, Hydrolyzed Hyaluronic Acid, Hydrolyzed Linseed Extract, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, Trisodium Ethylenediamine Disuccinate, Tocopheryl Acetate, Cera Alba, Orbignya Oleifera Seed Oil, Simmondsia Chinen Be the first to review These ingredients are found in both products. Ingredients higher up in an ingredient list are typically present in a larger amount. Adenosine is a purine nucleoside that your body already makes in every cell. In skincare, it acts mainly as a skin conditioning and anti-aging agent. The way it works is fairly well mapped out: Your skin has cells called fibroblasts that build collagen (the stuff that keeps skin firm and smooth). Adenosine basically flips a switch on these cells that tells them to get to work making more collagen and other proteins. These cells slow down on their own as skin ages, so Adenosine helps give them a little nudge to keep going. The clinical backing is pretty solid too. A blind, randomized, placebo-controlled trial of 126 women aged 45-65 tested a 0.1% cream twice daily and found real improvements in crow's feet and frown lines using a precise 3D skin-mapping technique; these changes showed up by week 3 and held at 2 months. A later study using Adenosine-loaded dissolving microneedle patches reported gains in wrinkle depth, dermal density, elasticity, and hydration. On concentrations, South Korea's Ministry of Food and Drug Safety has set 0.04% as the approved functional anti-wrinkle level. You'll typically see this ingredient used somewhere in the 0.04-0.1% range since it works at low doses. This ingredient has been found safe for cosmetics with the data showing no irritation or sensitization. Overall, this is a great ingredient for any anti-aging routine and has no photosensitizing effect, so it suits both AM and PM use. Capryloyl Salicylic Acid comes from salicylic acid, the famous acne-fighting BHA. It usually goes by a more common name of LHA, or lipohydroxy acid. Like salicylic acid, this ingredient is a chemical exfoliant that can help break down the oil in your pores and reduce inflammation. Though studies for LHA do show it to be less effective than salicylic acid. To be fair, salicylic acid is the reigning monarch of acne treatments. However, a study from 2009 found LHA to be comparable to BPO, making it a good alternative for people with sensitive skin. Another study of 14 patients found a significant decrease in comedones after using LHA. Another pro of LHA? It is less irritating than salicylic acid due to its large molecule size. Large molecules cannot penetrate skin as well, so they are gentler on the skin. LHA is much less penetrative than salicylic acid. An in-vitro study (not done on a living organism) found only 6% of LHA penetrated past the statum corneum compared to 58% of salicylic acid. An in-vivo (done on a living organism) analysis revealed ~17% of LHA was still present in the top layer of skin after 4 days, versus ~9% of salicylic acid. Interestingly, a study from 2008 found LHA comparable to another famous acid, glycolic acid. This study found about 10% of LHA is as effective as 20-50% of glycolic acid in treating hyperpigmentation and fine-lines. Hydroxy acids have been found to stimulate skin pro