Peptide Skincare & BeautySkin science and ingredient guides

Ingredient or product comparison

One Thing Niacinamide Glutathione Toner Versus One Thing Niacinamide Glutathione Serum

One Thing Niacinamide Glutathione Toner Versus One Thing Niacinamide Glutathione Serum Detailed comparison of One Thing Niacinamide Glutathione Toner versus One Thing Niacinamide Glutathione Serum. This brightening toner is formulated around Niacinamide and Gl

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One Thing Niacinamide Glutathione Toner Versus One Thing Niacinamide Glutathione Serum Detailed comparison of One Thing Niacinamide Glutathione Toner versus One Thing Niacinamide Glutathione Serum. This brightening toner is formulated around Niacinamide and Glutathione to brighten dull-looking skin and fade the look of dark spots. This brightening serum is formulated around Niacinamide and Glutathione to brighten dull-looking skin and fade the look of dark spots. Water Propanediol Butylene Glycol Glycerin Niacinamide Methylpropanediol Methyl Gluceth-20 1,2-Hexanediol Hydroxyacetophenone Trehalose Acrylates/C10-30 Alkyl Acrylate Crosspolymer Glycereth-25 PCA Isostearate Tromethamine Ethylhexylglycerin Coptis Japonica Root Extract Adenosine Citrus Unshiu Peel Extract Trisodium Ethylenediamine Disuccinate Glutathione 3-O-Ethyl Ascorbic Acid Ascorbic Acid Melaleuca Alternifolia Leaf Extract Sodium Ascorbate Tocopheryl Acetate Linoleic Acid Oleic Acid Palmitic Acid Stearic Acid Linolenic Acid Tocopherol Water, Propanediol, Butylene Glycol, Glycerin, Niacinamide, Methylpropanediol, Methyl Gluceth-20, 1,2-Hexanediol, Hydroxyacetophenone, Trehalose, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Glycereth-25 PCA Isostearate, Tromethamine, Ethylhexylglycerin, Coptis Japonica Root Extract, Adenosine, Citrus Unshiu Peel Extract, Trisodium Ethylenediamine Disuccinate, Glutathione, 3-O-Ethyl Ascorbic Acid, Ascorbic Acid, Melaleuca Alternifolia Leaf Extract, Sodium Ascorbate, Tocopheryl Acetate, Linoleic Acid, Oleic Acid, Palmitic Acid, Stearic Acid, Linolenic Acid, Tocopherol Citric Acid Xanthan Gum Zea Mays Silk Extract Disodium EDTA Hyaluronic Acid Hydrolyzed Hyaluronic Acid Sodium Hyaluronate Fructan Glucose Helianthus Annuus Seed Oil Water, Niacinamide, Butylene Glycol, Glycerin, Propanediol, 1,2-Hexanediol, Hydroxyacetophenone, Glycereth-25 PCA Isostearate, Coptis Japonica Root Extract, Citric Acid, Ethylhexylglycerin, Citrus Unshiu Peel Extract, Xanthan Gum, Zea Mays Silk Extract, Disodium EDTA, Glutathione, Hyaluronic Acid, Hydrolyzed Hyaluronic Acid, Sodium Hyaluronate, Fructan, Melaleuca Alternifolia Leaf Extract, Glucose, 3-O-Ethyl Ascorbic Acid, Ascorbic Acid, Sodium Ascorbate, Tocopheryl Acetate, Linoleic Acid, Tocopherol, Helianthus Annuus Seed Oil, Oleic Acid, Palmitic Acid, Stearic Acid, Linolenic Acid These ingredients are found in both products. Ingredients higher up in an ingredient list are typically present in a larger amount. 1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse. It is a: Humectant, drawing moisture into the skin Emollient, helping to soften skin Solvent, dispersing and stabilizing formulas Preservative booster, enhancing the antimicrobial activity of other preservatives 3-O-Ethyl Ascorbic Acid is one of the most popular "stable" vitamin C derivatives in skincare. Plain ascorbic acid is fantastic but notoriously fragile; it browns, oxidizes, and loses potency fast. So attaching an ethyl group to the third carbon of the molecule gives it some cool perks: In a formula, it does the 3 classic vitamin C jobs: it acts as an antioxidant, helps brighten skin tone by inhibiting tyrosinase, and supports collagen. The evidence is reasonably solid for a cosmetic ingredient; Liao and colleagues (2018) showed it's significantly more stable than ascorbic acid while still being effective. A 2021 study by Zerbinati and colleagues tested a serum with 30% 3-O-ethyl-l-ascorbic acid and 1% lactic acid significantly increased collagen production, reduced UVB-induced DNA damage, and decreased melanin on a reconstructed pigmented skin model. Typical real world usage sits around 0.5-5% (and 1-2% is common for daily serums). Amounts up to 30% have been shown to be non-irritating on human skin samples, but two isolated cases reported allergic contact dermatitis so a patch test is sensible if you have reactive skin. Ascorbic Acid is is pure Vitamin C and is the biologically active form used directly by skin. Not only is vitamin C great for your overall health and immune system, but it also has plenty of benefits for your skin. It is best supported by academic literature for: Topical vitamin C has been shown to help neutralize oxidative stress from UV and pollution, helping to improve photoaging and hyperpigmentation when used consistently. One clinical study found that using 5% topical vitamin C for six months improved signs of photodamaged skin, both on the surface and in the deeper structural layers of the skin. While vitamin C doesn’t replace sunscreen, studies show it can boost photoprotection when combined with Vitamin E and ferulic acid. These two ingredients help improve stability and protective effects. The big downside of this ingredient is formulation difficulty. Vitamin C is prone to oxidation and doesn't penetrate the skin unless formulated correctly. Research found that vitamin C absorbs into the skin best at a low pH (< 3.5) with about 20% being the upper limit for effective absorption. Skin levels can saturate after repeated application; this means your skin won’t keep absorbing more once it’s full of vitamin C. This is why more isn’t always better with vitamin C and why very high concentrations don’t necessarily give extra benefits. Ascorbic acid generally works well with many skincare ingredients but can be ir