Peptide Skincare & BeautySkin science and ingredient guides

Ingredient or product comparison

Peter Thomas Roth Peptide 21 Wrinkle Resist Serum Versus Peter Thomas Roth PRO Strength Niacinamide Discoloration Treatment

Peter Thomas Roth Peptide 21 Wrinkle Resist Serum Versus Peter Thomas Roth PRO Strength Niacinamide Discoloration Treatment Detailed comparison of Peter Thomas Roth Peptide 21 Wrinkle Resist Serum versus Peter Thomas Roth PRO Strength Niacinamide Discoloration

This source-based comparison does not add ratings or recommend a winner.

Peter Thomas Roth Peptide 21 Wrinkle Resist Serum Versus Peter Thomas Roth PRO Strength Niacinamide Discoloration Treatment Detailed comparison of Peter Thomas Roth Peptide 21 Wrinkle Resist Serum versus Peter Thomas Roth PRO Strength Niacinamide Discoloration Treatment. This anti-aging serum is formulated around Tripeptide-10 Citrulline and Acetyl Octapeptide-3 to soften the look of wrinkles. This brightening treatment is formulated around Niacinamide and Tranexamic Acid to fade the look of dark spots and brighten dull-looking skin. Water Glycerin Rosa Centifolia Flower Water Isopropyl Myristate Squalane Mannitol Butylene Glycol Natto Gum Tripeptide-10 Citrulline Acetyl Octapeptide-3 Palmitoyl Hexapeptide-12 Acetyl Tetrapeptide-11 Acetyl Hexapeptide-8 Acetyl Hexapeptide-1 Palmitoyl Oligopeptide Acetyl Tetrapeptide-9 Acetyl Tetrapeptide-2 Tripeptide-1 Palmitoyl Tetrapeptide-7 Hexapeptide-11 Dipeptide Diaminobutyroyl Benzylamide Diacetate Palmitoyl Tripeptide-5 Trifluoroacetyl Tripeptide-2 Palmitoyl Tripeptide-1 Sodium Polyglutamate Sodium Hyaluronate Tocopheryl Acetate Retinyl Palmitate Ascorbic Acid Hydrolyzed Soy Protein Hydrolyzed Wheat Protein Lecithin Pseudoalteromonas Ferment Extract Acrylates Copolymer Magnesium Chloride Polysorbate 20 Dimethyl Isosorbide Acrylates/C10-30 Alkyl Acrylate Crosspolymer Leuconostoc/Radish Root Ferment Filtrate PEG-8 Dimethicone Disodium Phosphate Carbomer Dextran Sodium Lactate Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate Xanthan Gum Triethanolamine Sodium Phosphate Octyldodecanol Silica Sodium Propoxyhydroxypropyl Thiosulfate Silica Sodium Hydroxide Caprylyl Glycol Potassium Sorbate Sodium Benzoate Phenoxyethanol Water, Glycerin, Rosa Centifolia Flower Water, Isopropyl Myristate, Squalane, Mannitol, Butylene Glycol, Natto Gum, Tripeptide-10 Citrulline, Acetyl Octapeptide-3, Palmitoyl Hexapeptide-12, Acetyl Tetrapeptide-11, Acetyl Hexapeptide-8, Acetyl Hexapeptide-1, Palmitoyl Oligopeptide, Acetyl Tetrapeptide-9, Acetyl Tetrapeptide-2, Tripeptide-1, Palmitoyl Tetrapeptide-7, Hexapeptide-11, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Palmitoyl Tripeptide-5, Trifluoroacetyl Tripeptide-2, Palmitoyl Tripeptide-1, Sodium Polyglutamate, Sodium Hyaluronate, Tocopheryl Acetate, Retinyl Palmitate, Ascorbic Acid, Hydrolyzed Soy Protein, Hydrolyzed Wheat Protein, Lecithin, Pseudoalteromonas Ferment Extract, Acrylates Copolymer, Magnesium Chloride, Polysorbate 20, Dimethyl Isosorbide, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Leuconostoc/Radish Root Ferment Filtrate, PEG-8 Dimethicone, Disodium Phosphate, Carbomer, Dextran, Sodium Lactate, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Xanthan Gum, Triethanolamine, Sodium Phosphate, Octyldodecanol, Silica, Sodium Propoxyhydroxypropyl Thiosulfate Silica, Sodium Hydroxide, Caprylyl Glycol, Potassium Sorbate, Sodium Benzoate, Phenoxyethanol Niacinamide Isononyl Isononanoate Tranexamic Acid Dimethicone Propanediol Pentylene Glycol Caprylic/Capric Triglyceride Alpha-Arbutin Glyceryl Stearate C9-12 Alkane Cetyl Alcohol Butyrospermum Parkii Butter Citric Acid Kojic Acid Morus Alba Root Extract Resveratrol Scutellaria Lateriflora Extract Hydrangea Arborescens Root Extract Hydrolyzed Vegetable Protein PEG-100 Stearate Polyacrylate Crosspolymer-6 PEG-75 Stearate Ceteareth-20 Steareth-20 Ammonium Acryloyldimethyltaurate/Beheneth-25 Methacrylate Crosspolymer Dimethiconol Coco-Caprylate/Caprate Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer Titanium D These ingredients are found in both products. Ingredients higher up in an ingredient list are typically present in a larger amount. Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created. Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin. Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on). Dimethyl Isosorbide (often shortened to DMI) is a sugar-derived solvent made from sorbitol. It's used to dissolve tricky ingredients and help them mix smoothly into a formula. Many actives sit as gritty crystals when undissolved, so DMI swoops in to full dissolve them. This helps improve texture, stability, and how evenly an active is distributed. It does have a penetration-enhancing reputation that is a bit more nuanced than marketing suggests; a cell study on human skin found that 10% DMI didn't significantly boost the permeation of Hydroquinone, Salicylic Acid, or Octadecenedioic Acid compared to controls (though it did improve their solubility in the formula itself). Typical usage concentrations usually range from 1-10% depending on the formula's needs; this ingredient is also well tolerated at these levels. Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!). It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome. On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive. Another perk of this ingredient is that it stays functional across a wide pH range (3-10). You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own. Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU. Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages. Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon. Polysorbate 20 is a gentle, water-soluble emulsifier and mild surfactant. It stops oil and water from separating to keep your formulas blended and stable. It also acts as a mild penetration enhancer by helping active ingredients absorb slightly better. The common safety discussion around this ingredient involves a m