Peptide Skincare & BeautySkin science and ingredient guides

Skin science article

Biossance 100% Squalane Oil Versus Niod Copper Amino Isolate Serum 2:1 (CAIS2)

Biossance 100% Squalane Oil Versus Niod Copper Amino Isolate Serum 2:1 (CAIS2) This hydrating oil is formulated around Squalane to hydrate skin and strengthen the skin barrier. This serum is formulated around Lactococcus Ferment Lysate to support the skin barr

By Peptide Skincare & Beauty Editorial TeamPublished

Biossance 100% Squalane Oil Versus Niod Copper Amino Isolate Serum 2:1 (CAIS2)

This hydrating oil is formulated around Squalane to hydrate skin and strengthen the skin barrier.

This serum is formulated around Lactococcus Ferment Lysate to support the skin barrier and reduce redness.

What's inside

Key Ingredients

No key ingredients

Benefits

Concerns

No concerns

Ingredients Side-by-side

Squalane

Water

Lactococcus Ferment Lysate

Glycerin

Ethyl Linoleate

Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer

Hexanoyl Dipeptide-3 Norleucine Acetate

Myristoyl Nonapeptide-3

Yeast Extract

Soy Amino Acids

Bisabolol

Pseudoalteromonas Exopolysaccharides

Lecithin

Sorbitan Isostearate

Isohexadecane

Polysorbate 60

Polyacrylate Crosspolymer-6

Trisodium Ethylenediamine Disuccinate

Sodium Salicylate

Citric Acid

Sodium Chloride

Potassium Sorbate

Sodium Benzoate

Pentylene Glycol

Ethoxydiglycol

Phenoxyethanol

Chlorphenesin

Water, Lactococcus Ferment Lysate, Glycerin, Ethyl Linoleate, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Hexanoyl Dipeptide-3 Norleucine Acetate, Myristoyl Nonapeptide-3, Yeast Extract, Soy Amino Acids, Bisabolol, Pseudoalteromonas Exopolysaccharides, Lecithin, Sorbitan Isostearate, Isohexadecane, Polysorbate 60, Polyacrylate Crosspolymer-6, Trisodium Ethylenediamine Disuccinate, Sodium Salicylate, Citric Acid, Sodium Chloride, Potassium Sorbate, Sodium Benzoate, Pentylene Glycol, Ethoxydiglycol, Phenoxyethanol, Chlorphenesin

Reviews

Be the first to review

Alternatives

Similar Comparisons

The reference edit

Ingredients, questions
& further reading.

Connected source records selected through this article’s public topic index.

01

Formula cabinet

Ingredients & structured notes

Ingredient index

Ingredients Explained

  1. 01These ingredients are found in both products.
  2. 02Ingredients higher up in an ingredient list are typically present in a larger amount.
  3. 03Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.
  4. 04Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.
  5. 05Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).
  6. 06Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
  7. 07Topically, glycerin does several things at once:
  8. 08Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
  9. 09Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
  10. 10This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
  11. 11Just know very high concentrations (>40%) can feel tacky in low humidity.
  12. 12Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
  13. 13Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).
  14. 14It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.
  15. 15On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.
  16. 16Another perk of this ingredient is that it stays functional across a wide pH range (3-10).
  17. 17You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.
  18. 18Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.
  19. 19Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.
  20. 20Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.
Source · skinsort.com ⟶
02

Product index

Related product references

03

Comparison edit

Read side by side

Continue reading

Related articles