Peptide Skincare & BeautySkin science and ingredient guides

Skin science article

Dear, Klairs Supple Preparation Unscented Toner Versus Paula's Choice Skin Recovery Enriched Calming Toner

Dear, Klairs Supple Preparation Unscented Toner Versus Paula's Choice Skin Recovery Enriched Calming Toner This hydrating toner is formulated around Glycyrrhiza Glabra Root Extract and Centella Asiatica Extract to hydrate skin and calm redness. This barrier-re

Dear, Klairs Supple Preparation Unscented Toner Versus Paula's Choice Skin Recovery Enriched Calming Toner

This hydrating toner is formulated around Glycyrrhiza Glabra Root Extract and Centella Asiatica Extract to hydrate skin and calm redness.

This barrier-repair toner is formulated around Oenothera Biennis Oil and Borago Officinalis Seed Oil to strengthen the skin barrier and calm redness.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Butylene Glycol

Dimethyl Sulfone

Betaine

Caprylic/Capric Triglyceride

Disodium EDTA

Glycyrrhiza Glabra Root Extract

Centella Asiatica Extract

Chlorphenesin

Tocopheryl Acetate

Glycerin

Arginine

Carbomer

Panthenol

Luffa Cylindrica Fruit/Leaf/Stem Extract

1,2-Hexanediol

Hydroxyethylcellulose

Aloe Barbadensis Leaf Extract

Althaea Rosea Flower Extract

Portulaca Oleracea Extract

Polyquaternium-51

Beta-Glucan

Lysine Hcl

Sodium Ascorbyl Phosphate

Sodium Hyaluronate

Acetyl Methionine

Theanine

Proline

Natto Gum

Disodium Phosphate

Polysorbate 60

Sodium Phosphate

Copper Tripeptide-1

Water, Butylene Glycol, Dimethyl Sulfone, Betaine, Caprylic/Capric Triglyceride, Disodium EDTA, Glycyrrhiza Glabra Root Extract, Centella Asiatica Extract, Chlorphenesin, Tocopheryl Acetate, Glycerin, Arginine, Carbomer, Panthenol, Luffa Cylindrica Fruit/Leaf/Stem Extract, 1,2-Hexanediol, Hydroxyethylcellulose, Aloe Barbadensis Leaf Extract, Althaea Rosea Flower Extract, Portulaca Oleracea Extract, Polyquaternium-51, Beta-Glucan, Lysine Hcl, Sodium Ascorbyl Phosphate, Sodium Hyaluronate, Acetyl Methionine, Theanine, Proline, Natto Gum, Disodium Phosphate, Polysorbate 60, Sodium Phosphate, Copper Tripeptide-1

Cyclopentasiloxane

Glycereth-26

Dimethiconol

Oenothera Biennis Oil

Borago Officinalis Seed Oil

Tocopherol

Ascorbyl Palmitate

Allantoin

Hydrogenated Lecithin

Niacinamide

Superoxide Dismutase

PEG-40 Hydrogenated Castor Oil

Myristamidopropyl Pg-Dimonium Chloride Phosphate

Laureth-4

Laureth-23

Sodium Benzoate

Phenoxyethanol

Benzoic Acid

Sorbic Acid

Water, Cyclopentasiloxane, Butylene Glycol, Glycereth-26, Dimethiconol, Oenothera Biennis Oil, Borago Officinalis Seed Oil, Sodium Hyaluronate, Tocopheryl Acetate, Tocopherol, Ascorbyl Palmitate, Panthenol, Allantoin, Glycerin, Hydrogenated Lecithin, Caprylic/Capric Triglyceride, Niacinamide, Superoxide Dismutase, PEG-40 Hydrogenated Castor Oil, Myristamidopropyl Pg-Dimonium Chloride Phosphate, Laureth-4, Laureth-23, Disodium EDTA, Sodium Benzoate, Chlorphenesin, Phenoxyethanol, Benzoic Acid, Sorbic Acid

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Caprylic/Capric Triglyceride (aka MCT Oil) is a lightweight emollient, solvent, and texture enhancer. It is considered a skin-softener by helping to prevent moisture loss.

Though it behaves like an oil, it is not technically one due to its chemical composition. One perk of this ingredient is that it is very stable, resistant to oxidation, and unlikely to go rancid.

In practice, that translates to a long shelf life and a consistently elegant skin feel.

While there is an assumption Caprylic Triglyceride can clog pores due to it being derived from coconut oil, there is no research supporting this. Just patch test if you have concerns.

Fractionated coconut oil and MCT Oil are both listed as Caprylic/Capric Triglyceride according to INCI. This is because INCI names are based on the ingredient’s final chemical composition and not its marketing name or source.

This ingredient is treated as the gold standard fungal acne safe oil. Even though it is coconut derived, the problematic lauric acid is stripped out.

This leaves just caprylic (C8) and capric (C10) acid. These chain lengths actually trend antifungal; a 2020 study found caprylic acid was enough to disrupt Malassezia furfur cell membrane, with a caprylic acid derivative damaging membrane structures at concentrations as low as 0.2%.

Chlorphenesin is a synthetic preservative. It helps protect a product against bacteria in order to extend shelf life. In most cases, Chlorphenesin is paired with other preservatives such as phenoxyethanol and caprylyl glycol.

Chlorphenesin is a biocide. This means it is able to help fight the microorganisms on our skin. It is also able to fight odor-releasing bacteria.

Chlorphenesin is soluble in both water and glycerin.

Studies show Chlorphenesin is easily absorbed by our skin. You should speak with a skincare professional if you have concerns about using Chlorphenesin.

Disodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air.

This ingredient mainly works behind the scenes and helps with:

On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it.

One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin).

Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption.

You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Panthenol is a common ingredient that helps hydrate and soothe the skin. It is found naturally in our skin and hair.

There are two forms of panthenol: D and L.

D-panthenol is also known as dexpanthenol. Most cosmetics use dexpanthenol or a mixture of D and L-panthenol.

Panthenol is famous due to its ability to go deeper into the skin's layers. Using this ingredient has numerous pros (and no cons):

Like hyaluronic acid, panthenol is a humectant. Humectants are able to bind and hold large amounts of water to keep skin hydrated.

This ingredient works well for wound healing. It works by increasing tissue in the wound and helps close open wounds.

Once oxidized, panthenol converts to pantothenic acid. Panthothenic acid is found in all living cells.

This ingredient is also referred to as pro-vitamin B5.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Tocopheryl Acetate is a stable, shelf-friendly form of vitamin E.

Formulators love it because plain vitamin E oxidizes quickly once it hits air. This acetate version stays stable and resists going off, helping to extend a product's shelf life.

It's actually inactive on its own and works like a slow-release "storage" form; the enzymes in your skin called esterases gradually convert it into active vitamin E over time.

One in vivo study showed 5% of the acetate in the living layer of the epidermis converted to vitamin E after 5 days of application. This study also found the skin gained protection against UV damage even though the conversion was slow and small.

Once converted, vitamin E acts as a skin's main fat-soluble antioxidant that fights free radicals to protect skin from damage.

Topical vitamin E generally boosts the skin's photoprotection, and it reduced UV-damage in animal models.

This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.

Overall, it has a pretty solid safety profile and has been found to be non-irritating and non-comedogenic. Allergic reactions may happen but stay rare due to how widely the ingredient gets used.

The concentration will vary depending on the formula; industry data shows 0.1% in baby lotions, 3% in lipsticks, and 5% in foot powders. You can also find this ingredient at 100% in a pure vitamin E oil.

Most leave-on skincare keeps it at the lower end, often between 0.5-1%.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Similar Comparisons

The reference edit

Ingredients, questions
& further reading.

Connected source records selected through this article’s public topic index.

01

Formula cabinet

Ingredients & structured notes

Ingredient index

Paula's Choice Advanced Sun Protection Daily Moisturizer SPF 50+Ingredients explained

  1. 01Good old water, aka H2O. The most common skincare ingredient of all. You can usually find it right in the very first spot of the ingredient list, meaning it’s the biggest thing out of all the stuff that makes up the product.
  2. 02It’s mainly a solvent for ingredients that do not like to dissolve in oils but rather in water.
  3. 03Expand to read more
  4. 04Once inside the skin, it hydrates, but not from the outside - putting pure water on the skin (hello long baths!) is drying.
  5. 05One more thing: the water used in cosmetics is purified and deionized (it means that almost all of the mineral ions inside it is removed). Like this, the products can stay more stable over time.
  6. 06A clear, colorless, odorless oily liquid that makes the formula easily spreadable and also makes the skin nice and smooth (emollient). It's especially helpful in sunscreens as it can help to solubilize UV filters.
  7. 07Diethylamino Hydroxybenzoyl Hexyl Benzoate is a new generation, chemical sunscreen agent (not available in the US due to impossible FDA regulations) that's designed for high UVA protection and high photostability. It gives sun protection in the whol…
  8. 08A crystal clear, oily liquid that makes your skin nice and smooth, aka emollient. It is fast-spreading and leaves a luxurious, silky-soft after-feel. It is also ideal for sunscreen products as it can enhance the solubility of crystalline UV filters.
  9. 09A clear, colorless, almost odorless oil that spreads nicely and easily and gives a velvet dry skin feel. It is good friends with sunscreen agents and helps to solubilize them. Also, it makes sunscreens feel lighter and spread easier.
  10. 10A colorless to light yellowish oily liquid that works as a UVB (280-320nm) sunscreen filter with a peak absorbance at 306 nm. It's not a strong filter in itself, it's always used in combination with other sunscreen agents to further enhance the SPF …
  11. 11It has a good safety profile and is allowed to be used at a max concentration of 5% both in the US and in Europe (10% is allowed in Japan).
  12. 12Ethylhexyl Triazone is a new generation, chemical sunscreen (not available in the US due to impossible FDA regulations) that gives the highest photo-stable absorption of all available UVB filters today. It protects in the UVB range (280-320nm) with …
  13. 13The long name covers a nice sunscreen agent and quite a special one at that: It's a "hybrid" sunscreen meaning it's half-way between physical (the ones that, at least partly, reflect the sun) and chemical agents (that absorb the rays, which most sun…
  14. 14It gives nice broad-spectrum coverage (280-400 nm, meaning UVB as well as UVA protecion) with peak protection at 305 nm and 360 nm and it is highly photostable. It can also help to stabilize other less stable sunscreens, like Octinoxate and is gener…
  15. 15Its hybrid nature means that it is organic like the chemical agents, but it is neither water nor oil soluble and works as a suspension of micro fine particles. If the small particles scare you, we have good news: the safety profile of Tinosorb M is …
  16. 16The downside of its hybrid nature is that - similar to the inorganic sunscreens zinc and titanium dioxide - Tinosorb M also leaves a white cast on the skin that can be bothersome on darker skin tones.
  17. 17We don't have description for this ingredient yet.
  18. 18Its INCI name is a bit of a mouthful, but Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine is worth recognizing it as it is one of the best sunscreen agents known today. Unfortunately, it's not FDA-approved so you will not find it in sunscreens coming…
  19. 19It is a broad-spectrum (covers the whole UVB and UVA range, 280-400 nm) chemical sunscreen agent with peak protections at about 310 and 345 nm and unlike older UV filters, it's very photostable. It hardly deteriorates in the presence of UV light and…
  20. 20It's a new generation sunscreen agent that was specifically designed for high SPF and good UVA protection and based on a 2007 study that compared 18 sunscreen agents available in the EU it really had the best SPF protection (they used the highest co…
Source · incidecoder.com
02

Product index

Related product references

03

Comparison edit

Read side by side