Skin science article
Elevai Enfinity Versus SkinMedica TNS® Advanced+ Serum
Elevai Enfinity Versus SkinMedica TNS® Advanced+ Serum This anti-aging serum is formulated around Niacinamide to soften the look of wrinkles and strengthen the skin barrier. What's inside Key Ingredients Benefits Concerns Ingredients Side-by-side Human Umbilic
Elevai Enfinity Versus SkinMedica TNS® Advanced+ Serum
This anti-aging serum is formulated around Niacinamide to soften the look of wrinkles and strengthen the skin barrier.
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Human Umbilical Mesenchymal Stem Cell Conditioned Media
Water
Glycerin
Aloe Barbadensis Leaf Juice
Sodium Hyaluronate
Niacinamide
Panthenol
Magnesium Ascorbyl Phosphate
Ascorbyl Glucoside
Sodium Ascorbyl Phosphate
Hydroxyethylcellulose
Caesalpinia Spinosa Gum
Bis(Tripeptide-1) Copper Acetate
Polysorbate 20
Polysorbate 60
Ceramide NP
Ceramide AP
Ceramide EOP
Acetyl Octapeptide-3
Palmitoyl Tripeptide-37
Palmitoyl Tripeptide-1
Palmitoyl Tetrapeptide-7
Acetyl Hexapeptide-8
Trifluoroacetyl Tripeptide-2
Dextran
Tetrahexyldecyl Ascorbate
Pullulan
Arginine
Glutathione
Yeast Extract
Nannochloropsis Oculata Extract
Camellia Sinensis Leaf Extract
Citrullus Lanatus Fruit Extract
Pyrus Malus Fruit Extract
Lens Esculenta Fruit Extract
Sodium PCA
Sodium Lactate
Sodium Phytate
Leuconostoc/Radish Root Ferment Filtrate
Caprylyl Glycol
Ethylhexylglycerin
Phytosphingosine
Cholesterol
Sodium Lauroyl Lactylate
Carbomer
Xanthan Gum
Phenoxyethanol
Hexylene Glycol
Butylene Glycol
Disodium Phosphate
Sodium Phosphate
Sodium Benzoate
Potassium Sorbate
Human Umbilical Mesenchymal Stem Cell Conditioned Media, Water, Glycerin, Aloe Barbadensis Leaf Juice, Sodium Hyaluronate, Niacinamide, Panthenol, Magnesium Ascorbyl Phosphate, Ascorbyl Glucoside, Sodium Ascorbyl Phosphate, Hydroxyethylcellulose, Caesalpinia Spinosa Gum, Bis(Tripeptide-1) Copper Acetate, Polysorbate 20, Polysorbate 60, Ceramide NP, Ceramide AP, Ceramide EOP, Acetyl Octapeptide-3, Palmitoyl Tripeptide-37, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Acetyl Hexapeptide-8, Trifluoroacetyl Tripeptide-2, Dextran, Tetrahexyldecyl Ascorbate, Pullulan, Arginine, Glutathione, Yeast Extract, Nannochloropsis Oculata Extract, Camellia Sinensis Leaf Extract, Citrullus Lanatus Fruit Extract, Pyrus Malus Fruit Extract, Lens Esculenta Fruit Extract, Sodium PCA, Sodium Lactate, Sodium Phytate, Leuconostoc/Radish Root Ferment Filtrate, Caprylyl Glycol, Ethylhexylglycerin, Phytosphingosine, Cholesterol, Sodium Lauroyl Lactylate, Carbomer, Xanthan Gum, Phenoxyethanol, Hexylene Glycol, Butylene Glycol, Disodium Phosphate, Sodium Phosphate, Sodium Benzoate, Potassium Sorbate
Pentylene Glycol
Human Neonatal Fibroblast Conditioned Media
Glycereth-7 Triacetate
Shea Butter Ethyl Esters
Ethoxydiglycol
Lactococcus Ferment Lysate
Whey Protein
Chlorella Vulgaris Extract
Saccharide Isomerate
Dimer Tripeptide-43
Vitis Vinifera Flower Cell Extract
Hydroxyacetophenone
Tocopheryl Acetate
Propanediol
Polyacrylate Crosspolymer-6
Polyacrylate-13
Polyisobutene
Sclerotium Gum
PEG-12 Dimethicone
Lecithin
Sodium Citrate
Aminomethyl Propanol
Disodium EDTA
Water, Pentylene Glycol, Human Neonatal Fibroblast Conditioned Media, Glycereth-7 Triacetate, Shea Butter Ethyl Esters, Glycerin, Ethoxydiglycol, Lactococcus Ferment Lysate, Whey Protein, Chlorella Vulgaris Extract, Saccharide Isomerate, Dimer Tripeptide-43, Vitis Vinifera Flower Cell Extract, Pyrus Malus Fruit Extract, Hydroxyacetophenone, Tocopheryl Acetate, Propanediol, Xanthan Gum, Polyacrylate Crosspolymer-6, Polyacrylate-13, Polyisobutene, Sclerotium Gum, PEG-12 Dimethicone, Lecithin, Pullulan, Butylene Glycol, Sodium Citrate, Polysorbate 20, Aminomethyl Propanol, Disodium EDTA, Phenoxyethanol, Ethylhexylglycerin
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Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:
The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.
Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.
Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).
It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.
On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.
Another perk of this ingredient is that it stays functional across a wide pH range (3-10).
You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.
Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.
Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.
Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.
Polysorbate 20 is a gentle, water-soluble emulsifier and mild surfactant. It stops oil and water from separating to keep your formulas blended and stable.
It also acts as a mild penetration enhancer by helping active ingredients absorb slightly better.
The common safety discussion around this ingredient involves a manufacturing byproduct called 1,4-dioxane.
Trace amounts can form during production but the EU's Scientific Committee on Consumer Safety has concluded that levels at/below 10 ppm in finished products are safe (commercial products consistently fall within acceptable margins).
True allergic reactions are uncommon and the CIR Expert Panel has confirmed this ingredient to be safe as used in cosmetics.
Because it is derived from lauric acid, it may not be fungal acne safe.
Pullulan is a low viscosity polysaccharide (a long chain carbohydrate) with binding and film forming properties when dissolved in water. It is used to create a "silicone-like" or silky feel in cosmetics without adding viscosity.
According to a manufacturer, this ingredient's ability to easily dissolves makes it a great carrier for active ingredients.
Due to it being edible and tasteless, you'll likely find this ingredient in breath freshener strips. This ingredient is produced from the starch of the fungus, Aureobasidium pullulans.
Pullulan is stable over a broad-range of pH.
Pyrus Malus Fruit Extract is extract from Apples. Apples are rich in Vitamin C, sugars, and antioxidants.
The sugar in Apples are humectants and help hydrate the skin. On top of that, apples also contain some acids, such as malic acid. These acids may have a mild exfoliating effect.
Last, the phytochemicals found in apples are strong antioxidants. These antioxidants help with anti-aging as they protect your skin cells against oxidative damage.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.
On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.
Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.