Peptide Skincare & BeautySkin science and ingredient guides

Skin science article

Estée Lauder Resilience Multi-Effect Night Tri-Peptide Face And Neck Creme Versus Olay Regenerist Retinol 24 Max Night Hydrating Moisturizer

Estée Lauder Resilience Multi-Effect Night Tri-Peptide Face And Neck Creme Versus Olay Regenerist Retinol 24 Max Night Hydrating Moisturizer This anti-aging night moisturizer is formulated around Acetyl Hexapeptide-8 to soften the look of wrinkles. This anti-a

Estée Lauder Resilience Multi-Effect Night Tri-Peptide Face And Neck Creme Versus Olay Regenerist Retinol 24 Max Night Hydrating Moisturizer

This anti-aging night moisturizer is formulated around Acetyl Hexapeptide-8 to soften the look of wrinkles.

This anti-aging night moisturizer is formulated around Retinol and Niacinamide to soften the look of wrinkles and refine skin texture.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Caprylic/Capric/Myristic/Stearic Triglyceride

Petrolatum

Hexyldecyl Stearate

Butylene Glycol

Dimethicone

Glycereth-26

PEG-100 Stearate

Cetearyl Alcohol

Glyceryl Stearate

Propanediol

Narcissus Tazetta Bulb Extract

Cucumis Sativus Fruit Extract

Mimosa Tenuiflora Bark Extract

Hordeum Vulgare Extract

Cucumis Melo Fruit Extract

Persea Gratissima Oil

Whey Protein

Caffeine

Thermus Thermophillus Ferment

Algae Extract

Laminaria Digitata Extract

Artemia Extract

Acetyl Hexapeptide-8

Polygonum Cuspidatum Root Extract

Ergothioneine

Trifluoroacetyl Tripeptide-2

Trehalose

Sorbitol

Glycerin

Decarboxy Carnosine Hcl

Cholesterol

Isohexadecane

Acetyl Glucosamine

Myristyl Myristate

Cetearyl Glucoside

Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate

Propylene Glycol Dicaprylate

Aminopropyl Ascorbyl Phosphate

Caprylyl Glycol

Acrylates/C10-30 Alkyl Acrylate Crosspolymer

Caprylic/Capric Triglyceride

Tocopheryl Acetate

Linoleic Acid

Polysorbate 80

Faex Extract

Propylene Glycol Dicaprate

Zinc PCA

Helianthus Annuus Seedcake

Hexylene Glycol

Acrylamide/Sodium Acryloyldimethyltaurate Copolymer

Sodium Hyaluronate

Myristyl Alcohol

Tromethamine

Stearic Acid

Potassium Sulfate

Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate

Citric Acid

Maltodextrin

Aluminum Hydroxide

Parfum

Potassium Sorbate

Dextran

Disodium EDTA

BHT

Phenoxyethanol

CI 42090

CI 17200

CI 77891

Water, Caprylic/Capric/Myristic/Stearic Triglyceride, Petrolatum, Hexyldecyl Stearate, Butylene Glycol, Dimethicone, Glycereth-26, PEG-100 Stearate, Cetearyl Alcohol, Glyceryl Stearate, Propanediol, Narcissus Tazetta Bulb Extract, Cucumis Sativus Fruit Extract, Mimosa Tenuiflora Bark Extract, Hordeum Vulgare Extract, Cucumis Melo Fruit Extract, Persea Gratissima Oil, Whey Protein, Caffeine, Thermus Thermophillus Ferment, Algae Extract, Laminaria Digitata Extract, Artemia Extract, Acetyl Hexapeptide-8, Polygonum Cuspidatum Root Extract, Ergothioneine, Trifluoroacetyl Tripeptide-2, Trehalose, Sorbitol, Glycerin, Decarboxy Carnosine Hcl, Cholesterol, Isohexadecane, Acetyl Glucosamine, Myristyl Myristate, Cetearyl Glucoside, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Propylene Glycol Dicaprylate, Aminopropyl Ascorbyl Phosphate, Caprylyl Glycol, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Caprylic/Capric Triglyceride, Tocopheryl Acetate, Linoleic Acid, Polysorbate 80, Faex Extract, Propylene Glycol Dicaprate, Zinc PCA, Helianthus Annuus Seedcake, Hexylene Glycol, Acrylamide/Sodium Acryloyldimethyltaurate Copolymer, Sodium Hyaluronate, Myristyl Alcohol, Tromethamine, Stearic Acid, Potassium Sulfate, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, Citric Acid, Maltodextrin, Aluminum Hydroxide, Parfum, Potassium Sorbate, Dextran, Disodium EDTA, BHT, Phenoxyethanol, CI 42090, CI 17200, CI 77891

Tapioca Starch

Dimethicone Crosspolymer

Retinol

Retinyl Propionate

Niacinamide

Tropaeolum Majus Flower/Leaf/Stem Extract

Palmitoyl Pentapeptide-4

Dimethiconol

Laureth-4

Polysorbate 20

Laureth-7

Polyacrylamide

Aminomethyl Propanol

Polymethylsilsesquioxane

Titanium Dioxide

C13-14 Isoparaffin

DMDM Hydantoin

Iodopropynyl Butylcarbamate

Plant Ash Extract

Avena Sativa Peptide

Water, Dimethicone, Glycerin, Tapioca Starch, Dimethicone Crosspolymer, Retinol, Retinyl Propionate, Niacinamide, Tropaeolum Majus Flower/Leaf/Stem Extract, Palmitoyl Pentapeptide-4, Dimethiconol, Laureth-4, Polysorbate 20, Laureth-7, Disodium EDTA, Polyacrylamide, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Aminomethyl Propanol, Polymethylsilsesquioxane, Titanium Dioxide, C13-14 Isoparaffin, DMDM Hydantoin, Iodopropynyl Butylcarbamate, Plant Ash Extract, Avena Sativa Peptide

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Acrylates/C10-30 Alkyl Acrylate Crosspolymer is a synthetic polymer. It is used to thicken, emulsify, and improve the texture of products.

As an emulsifier, it helps stabilize oil-in-water emulsions to give products an elegant feel when applied.

It can also form a thin protective film on skin. One study found that a formula using this polymer helped slow down how quickly other ingredients (like DEET) were absorbed through skin.

A 2024 study of over 1,300 patients confirmed that sensitization to this ingredient is rare. It is also non-mutagenic and has a clean track record.

Dimethicone is a type of synthetic silicone created from natural materials such as quartz. It is also known as polydimethylsiloxane.

What it does:

Dimethicone comes in different viscosities:

Depending on the viscosity, dimethicone has different properties.

Ingredients lists don't always show which type is used, so we recommend reaching out to the brand if you have questions about the viscosity.

This ingredient is unlikely to cause irritation because it does not get absorbed into skin. However, people with silicone allergies should be careful about using this ingredient.

Note: Dimethicone may contribute to pilling. This is because it is not oil or water soluble, so pilling may occur when layered with products. When mixed with heavy oils in a formula, the outcome is also quite greasy.

Disodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air.

This ingredient mainly works behind the scenes and helps with:

On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it.

One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin).

Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption.

You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Similar Comparisons

The reference edit

Ingredients, questions
& further reading.

Connected source records selected through this article’s public topic index.

02

Product index

Related product references

03

Comparison edit

Read side by side