Peptide Skincare & BeautySkin science and ingredient guides

Skin science article

Estée Lauder Revitalizing Supreme+ Global Anti-Aging Cell Power Creme SPF 15 Versus Estée Lauder Resilience Multi-Effect Tri-Peptide Face And Neck Creme SPF 15

Estée Lauder Revitalizing Supreme+ Global Anti-Aging Cell Power Creme SPF 15 Versus Estée Lauder Resilience Multi-Effect Tri-Peptide Face And Neck Creme SPF 15 This anti-aging moisturizer is formulated around Moringa Oleifera Seed Extract and Acetyl Glucosamin

Estée Lauder Revitalizing Supreme+ Global Anti-Aging Cell Power Creme SPF 15 Versus Estée Lauder Resilience Multi-Effect Tri-Peptide Face And Neck Creme SPF 15

This anti-aging moisturizer is formulated around Moringa Oleifera Seed Extract and Acetyl Glucosamine to soften the look of wrinkles and hydrate skin.

This anti-aging day moisturizer is formulated around Acetyl Hexapeptide-8 to soften the look of wrinkles.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Octocrylene

Butyloctyl Salicylate

Ethylhexyl Salicylate

Glycerin

Butyl Methoxydibenzoylmethane

Polysorbate 60

Cetyl Alcohol

Sorbitan Stearate

Dimethicone

Tridecyl Stearate

Butylene Glycol

Pentylene Glycol

Moringa Oleifera Seed Extract

Opuntia Tuna Fruit Extract

Hordeum Vulgare Extract

Cucumis Sativus Fruit Extract

Narcissus Tazetta Bulb Extract

Sigesbeckia Orientalis Extract

Pyrus Malus Fruit Extract

Lens Esculenta Fruit Extract

Whey Protein

Citrullus Lanatus Fruit Extract

Caffeine

Algae Extract

Laminaria Digitata Extract

Tocopheryl Acetate

Acetyl Glucosamine

Astrocaryum Murumuru Seed Butter

Sucrose

Tridecyl Trimellitate

Dipentaerythrityl Hexacaprylate/Hexacaprate

PEG-100 Stearate

Trehalose

Cetyl Palmitate

Sorbitol

Acetyl Hexapeptide-8

Sodium Lactate

Acrylates/C10-30 Alkyl Acrylate Crosspolymer

Sodium Benzoate

Sorbitan Palmitate

Sorbitan Olivate

Ethylhexylglycerin

Sodium PCA

Vp/Hexadecene Copolymer

Sodium Polyacrylate

Propylene Glycol Dicaprate

Sodium Hyaluronate

Isoceteth-20

Helianthus Annuus Seedcake

Polyethylene

Parfum

Tetrahexyldecyl Ascorbate

Sodium Hydroxide

Disodium EDTA

BHT

Phenoxyethanol

Chlorphenesin

CI 19140

CI 14700

Water, Octocrylene, Butyloctyl Salicylate, Ethylhexyl Salicylate, Glycerin, Butyl Methoxydibenzoylmethane, Polysorbate 60, Cetyl Alcohol, Sorbitan Stearate, Dimethicone, Tridecyl Stearate, Butylene Glycol, Pentylene Glycol, Moringa Oleifera Seed Extract, Opuntia Tuna Fruit Extract, Hordeum Vulgare Extract, Cucumis Sativus Fruit Extract, Narcissus Tazetta Bulb Extract, Sigesbeckia Orientalis Extract, Pyrus Malus Fruit Extract, Lens Esculenta Fruit Extract, Whey Protein, Citrullus Lanatus Fruit Extract, Caffeine, Algae Extract, Laminaria Digitata Extract, Tocopheryl Acetate, Acetyl Glucosamine, Astrocaryum Murumuru Seed Butter, Sucrose, Tridecyl Trimellitate, Dipentaerythrityl Hexacaprylate/Hexacaprate, PEG-100 Stearate, Trehalose, Cetyl Palmitate, Sorbitol, Acetyl Hexapeptide-8, Sodium Lactate, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Sodium Benzoate, Sorbitan Palmitate, Sorbitan Olivate, Ethylhexylglycerin, Sodium PCA, Vp/Hexadecene Copolymer, Sodium Polyacrylate, Propylene Glycol Dicaprate, Sodium Hyaluronate, Isoceteth-20, Helianthus Annuus Seedcake, Polyethylene, Parfum, Tetrahexyldecyl Ascorbate, Sodium Hydroxide, Disodium EDTA, BHT, Phenoxyethanol, Chlorphenesin, CI 19140, CI 14700

Neopentyl Glycol Diheptanoate

Pentaerythrityl Tetraethylhexanoate

Di-C12-15 Alkyl Fumarate

Petrolatum

Hydrogenated Lecithin

Propanediol

Hydrogenated Polyisobutene

Octyldodecyl Myristate

Hexyldecyl Stearate

Behenyl Alcohol

Cucumis Melo Fruit Extract

Polygonum Aviculare Extract

Myrtus Communis Leaf Extract

Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate

Lactoperoxidase

Glucose Oxidase

Cholesterol

Propylene Glycol Dicaprylate

Aminopropyl Ascorbyl Phosphate

Glucose

Artemia Extract

Glyceryl Stearate

Persea Gratissima Oil

C12-16 Alcohols

Palmitic Acid

Glycine Soja Sterols

Caprylyl Glycol

Isohexadecane

Polymethyl Methacrylate

Trifluoroacetyl Tripeptide-2

Zinc PCA

Polysilicone-11

Polysorbate 80

Faex Extract

Potato Starch Modified

Decarboxy Carnosine Hcl

Xanthan Gum

Potassium Sulfate

Acrylamide/Sodium Acryloyldimethyltaurate Copolymer

Dextran

Hexylene Glycol

Potassium Sorbate

Mica

CI 77891

Water, Neopentyl Glycol Diheptanoate, Ethylhexyl Salicylate, Butyl Methoxydibenzoylmethane, Octocrylene, Cetyl Alcohol, Glycerin, Butyloctyl Salicylate, Pentaerythrityl Tetraethylhexanoate, Polyethylene, Di-C12-15 Alkyl Fumarate, Petrolatum, Hydrogenated Lecithin, Butylene Glycol, Propanediol, Hydrogenated Polyisobutene, Octyldodecyl Myristate, Hexyldecyl Stearate, Behenyl Alcohol, Cucumis Melo Fruit Extract, Polygonum Aviculare Extract, Myrtus Communis Leaf Extract, Laminaria Digitata Extract, Acetyl Hexapeptide-8, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Lactoperoxidase, Glucose Oxidase, Cholesterol, Propylene Glycol Dicaprylate, Aminopropyl Ascorbyl Phosphate, Sodium Hyaluronate, Glucose, Algae Extract, Artemia Extract, Acetyl Glucosamine, Sigesbeckia Orientalis Extract, Glyceryl Stearate, Persea Gratissima Oil, Dimethicone, C12-16 Alcohols, Trehalose, Ethylhexylglycerin, PEG-100 Stearate, Caffeine, Palmitic Acid, Glycine Soja Sterols, Caprylyl Glycol, Isohexadecane, Polymethyl Methacrylate, Trifluoroacetyl Tripeptide-2, Tocopheryl Acetate, Zinc PCA, Polysilicone-11, Polysorbate 80, Faex Extract, Potato Starch Modified, Decarboxy Carnosine Hcl, Xanthan Gum, Parfum, Sodium Hydroxide, Potassium Sulfate, Acrylamide/Sodium Acryloyldimethyltaurate Copolymer, Dextran, Hexylene Glycol, Disodium EDTA, BHT, Potassium Sorbate, Phenoxyethanol, CI 14700, Mica, CI 77891

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Acetyl Glucosamine is an antioxidant and humectant. It is an amino acid sugar and is naturally found in our skin.

The cool thing about this ingredient? It helps the skin produce hyaluronic acid and boost hydration. It also has antioxidant benefits to protect skin cells.

When paired with niacinamide, Acetyl Glucosamine has been shown to be effective at reducing discoloration.

Acetyl Hexapeptide-8 (also known as Argireline) is a synthetic hexapeptide that is often called a "topical Botox alternative".

It works by mimicking how Botox relaxes muscles; it interferes with the signaling process that tells your facial muscles to contract. This can help soften expression lines like forehead wrinkles or crow's feet over time.

The comparison to Botox does have limits because the molecule is water-loving and relatively large.

Acetyl Hexapeptide-8 has a hard time absorbing deeply enough through the skin's outer barrier to actually reach the muscles.

So whether it truly works the way Botox does at a biological level is still up for debate, but early clinical outcomes are fairly encouraging.

A 12 week human study of a multi-ingredient regimen containing this ingredient saw:

While some studies have observed improvements in wrinkle appearance, it is important to note that more consistent results are seen in multi-ingredient formulations (vs just Acetyl Hexapeptide-8 alone).

Some research studies also used higher concentrations (up to 10%) while this ingredient is usually found in concentrations up to 0.005% in leave-on formulations.

Algae Extract is a confusing name. This is because algae is an informal term for a group of 30,000 aquatic organisms that can photosynthesize.

The term 'algae extract' can refer to any one, or a blend of, the 30,000 types.

Algae is rich in antioxidants. Antioxidants help fight free-radicals. Free-radicals are molecules that may damage your skin cells, such as pollution.

Algae can also help with soothing and hydrating skin.

Many different types of algae have different benefits.

BHT is a synthetic antioxidant and preservative.

As an antioxidant, it helps your body fight off free-radicals. Free-radicals are molecules that may damage your skin cells.

As a preservative, it is used to stabilize products and prevent them from degrading. Specifically, BHT prevents degradation from oxidation.

The concerns related to BHT come from oral studies; this ingredient is currently allowed for use by both the FDA and EU.

However, it was recently restricted for use in the UK as of April 2024.

Also known as Avobenzone, this ingredient is an oil-soluble used to absorb the full spectrum of UVA rays (peak 357 nm).

It's one of the most effective UVA filters available but has a major caveat of photostability: avobenzone is susceptible to photodegradation.

This means it can lose efficacy when exposed to sunlight without the help of a stabilizing agent.

Studies show antioxidants (like vitamin E or vitamin C) and some UV filters (like octocrylene and Tinosorb S) can meaningfully improve its stability in a formulation.

The maximum allowable concentration according to regulation is 3% in the US + Canada, and 5% in the EU, Australia, China, Korea, and ASEAN countries.

It has a well-support safety profile: a comprehensive 2025 review found minimal toxicity with no evidence of carcinogenicity.

Overall, avobenzone is a safe and regulated ingredient used in sunscreen for over 40 years.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Butyloctyl Salicylate is a chemical UV filter structurally similar to octisalate. It is a photostabilizer, SPF booster, emollient and solvent. This ingredient helps evenly spread out ingredients.

According to a manufacturer, it is suitable for pairing with micro Titanium Dioxide, Zinc Oxide, and pigments.

Photostabilizers help stabilize UV-filters and prevents them from degrading quickly.

Caffeine is a naturally occurring plant compound found in coffee beans, tea leaves, cocoa pods, and guarana.

As an antioxidant, caffeine protects your skin from free radical damage caused by UV exposure and envionrmnetal stressors.

Early research also shows that caffeine can help calm redness, soothe irritated skin, and support hair growth by stimulating microcirculation in the scalp.

You might have seen eye creams marketing caffeine as a depuffing ingredient. This is because it is a vasoconstrictor meaning it can temporarily constrict blood vessels, though clinical evidence for this specific use is still limited.

Most skincare products contain this ingredient at concentrations between 1-6%. It is able to penetrate skin easily regardless of skin type or thickness.

Just so you know, a very small number of case reports describe caffeine-induced allergy. This ingredient is generally well-tolerated, non-irritating, and non-sensitizing for the majority of people.

Cetyl Alcohol is a fatty alcohol. Fatty Alcohols are most often used as an emollient or to thicken a product.

Its main roles are:

Though it has "alcohol" in the name, it is not related to denatured alcohol or ethyl alcohol.

The FDA allows products labeled "alcohol-free" to have fatty alcohols.

This ingredient may not be fungal acne safe. It is a primary fatty alcohol with a chain length above 12 carbons. A study from 2019 show Malassezia can feed on fatty alcohols in this range, so it may trigger fungal acne in those prone to it.

Ci 14700, also known as Red No. 4, is a synthetic red dye derived from petroleum. It is water soluble.

Dimethicone is a type of synthetic silicone created from natural materials such as quartz. It is also known as polydimethylsiloxane.

What it does:

Dimethicone comes in different viscosities:

Depending on the viscosity, dimethicone has different properties.

Ingredients lists don't always show which type is used, so we recommend reaching out to the brand if you have questions about the viscosity.

This ingredient is unlikely to cause irritation because it does not get absorbed into skin. However, people with silicone allergies should be careful about using this ingredient.

Note: Dimethicone may contribute to pilling. This is because it is not oil or water soluble, so pilling may occur when layered with products. When mixed with heavy oils in a formula, the outcome is also quite greasy.

Disodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air.

This ingredient mainly works behind the scenes and helps with:

On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it.

One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin).

Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption.

You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%.

Ethylhexyl Salicylate (also called Octisalate or Octyl Salicylate) is an oil-soluble organic UV filter that's been used in sunscreen since the 1950's.

It absorbs UVB light in the 280-320 nm range with a peak absorbance around 306 nm.

You'll often see it paired with other UV filters to boost overall SPF because octisalate is a fairly week filter on its own.

The reason you'll see it so often is because it can help solubilize and stabilize the trickier filters like oxybenzone and avobenzone.

Unlike these filters, octisalate has pretty good photostability and doesn't create skin-damaging free radicals when exposed to sunlight.

The fatty-alcohol part of the molecule also gives it a light, emollient feel so it doubles as a nice texture enhancer.

Usage levels vary around the world:

Safety-wise, this ingredient has a pretty reassuring track record. The EU's Scientific Committee on Consumer Products (SCCP) found very low skin penetration in human skin tests and negative results for irritation, phototoxicity, and photoallergy.

The real-world allergy risk is pretty low too; a 2012 European study of 1,031 people recorded only 2 reactions to it (a rate of 0.19%).

You might have seen scary headlines about sunscreen getting into your blood.

In 2019, the FDA found that several chemical filters can absorb through the skin and show up in the bloodstream at small but measurable levels.

Here's the important part: these tiny levels are just a cutoff the FDA uses to decide which ingredients need more testing and doesn't mean anything harmful was found.

The researchers were clear that the results are no reason to stop wearing sunscreen.

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Laminaria Digitata Extract comes from the big brown seaweed (or kelp) that grows in the North Atlantic. In skincare, it's mostly used as a skin protectant and conditioning agent.

The most interesting stuff inside is mostly just sugars and minerals: fucoidan (a sulfated polysaccharide), laminarin (a beta-glucan), alginates, and phlorotannins (seaweed polyphenols).

Any antioxidant and soothing claims mostly come from those polysaccharides; crude laminarin and fucoidan from Laminaria digitata do show antioxidant and anti-inflammatory activity in lab assays.

Just know that the lab assays are test-tube work on isolated compounds and not clinical trials on the finished extract.

Realistically, this ingredient is a nice-feeling and hydrating skin conditioner (not really an active).

Safety-wise, it's one of the better documented seaweeds and safe to be used in cosmetics according to the CIR Expert Panel.

Industry surveys find that usage concentrations run can be found up to 5% in bubble baths and leave-on usage is more likely 0.1-3%.

The risk of allergy is also quite low as human repeat insult patch tests (under 5% and blends containing 8-12%) came back non-irritating and non-sensitizing. Rabbit studies came back negative too, though one trade mixture at 1.5-2.5% in water + propylene glycol did cause moderate irritation at 30 minutes.

Reported seaweed allergies in the literature are almost all occupational (people handling wet kelp) or from a totally unrelated blue/green alga.

At this time, there's actually no published comedogenicity test on it and the evidence that does exist points away from clogging.

Laminaria Digitata Extract has never been run through the rabbit ear assay or the Mills & Kligman human model and it isn't in Fulton's 1989 list of tested comedogenic ratings.

The CIR's brown algae review pulled every published and unpublished study industry had on 82 seaweed ingredients and found no comedogenicity data for any of them.

So any number you see online was assigned by a person and not actually measured.

In 2012, Capitanio et al. ran an 8-week double-blind, vehicle-controlled trial in 60 people with mild acne using a Laminaria digitata-derived oligosaccharide complexed with 0.1% zinc pyrrolidone.

They found comedones, papules and pustules dropped significantly more in the active group than the vehicle group at 2, 4 and 8 weeks.

Caveats for this study: a Laminaria digitata-derived oligosaccharide is just fraction and not the plain extract, and the zinc is likely doing real work. Still, the study found comedones went down in acne-prone skin.

This fits mechanistically. Comedogenesis is largely a lipid story and this is water-soluble polysaccharides, minerals, and polyphenols. There's nothing really to plug a follicle with.

The real caveat is the carrier: some supplier versions come dispersed in caprylic/capric triglycerides.

The 0-5 scale comes from applying ingredients to the inside of an albino rabbit's ear. Rabbit follicles are far more reactive than human ones so it over-predicts. Even petrolatum was reassigned as non-comedogenic by the original scientist, Kligman.

Here are three more problems of comedogenic ratings:

Octocrylene is an oil-soluble organic UV filter that mainly absorbs UVB and short wave UVA II light.

Its real superpower is teamwork: octocrylene is remarkably photostable and is most famous for stabilizing avobenzone (the workhorse UVA filter).

This ingredient is commonly used to enhance both UVB and UVA protection due to its unique property in stabilizing avobenzone. It also pulls double duty by boosting water resistance and giving formulas a smooth, spreadable feel.

The EU's Scientific Committee on Consumer Safety (SCCS) has deemed octocrylene to be safe as a UV-filter at concentrations up to 10% (capped at 9% in propellant sprays). The US also permits it up to 10%.

Two things worth knowing:

You'll usually see this ingredient used in concentrations between 2-10% (higher amounts when used as a stabilizer for avobenzone).

Parfum is a catch-all term for an ingredient or more that is used to give a scent to products.

Also called "fragrance", this ingredient can be a blend of hundreds of chemicals or plant oils. This means every product with "fragrance" or "parfum" in the ingredients list is a different mixture.

For instance, Habanolide is a proprietary trade name for a specific aroma chemical. When used as a fragrance ingredient in cosmetics, most aroma chemicals fall under the broad labeling category of “FRAGRANCE” or “PARFUM” according to EU and US regulations.

The term 'parfum' or 'fragrance' is not regulated in many countries. In many cases, it is up to the brand to define this term.

For instance, many brands choose to label themselves as "fragrance-free" because they are not using synthetic fragrances. However, their products may still contain ingredients such as essential oils that are considered a fragrance by INCI standards.

One example is Calendula flower extract. Calendula is an essential oil that still imparts a scent or 'fragrance'.

Depending on the blend, the ingredients in the mixture can cause allergies and sensitivities on the skin. Some ingredients that are known EU allergens include linalool and citronellol.

Parfum can also be used to mask or cover an unpleasant scent.

The bottom line is: not all fragrances/parfum/ingredients are created equally. If you are worried about fragrances, we recommend taking a closer look at an ingredient. And of course, we always recommend speaking with a professional.

Peg-100 Stearate is an emollient and emulsifier. As an emollient, it helps keep skin soft by trapping moisture in. On the other hand, emulsifiers help prevent oil and water from separating in a product.

PEGS are a hydrophilic polyether compound . There are 100 ethylene oxide monomers in Peg-100 Stearate. Peg-100 Stearate is polyethylene glycol ester of stearic acid.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Polyethylene is a synthetic ingredient that helps the skin retain moisture. It is a polymer.

It is also typically used within product formulations to help bind solid ingredients together and thicken oil-based ingredients. When added to balms and emulsions, it helps increase the melting point temperature.

We don't have a description for Sigesbeckia Orientalis Extract yet.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Sodium Hydroxide is also known as lye or caustic soda. It is used to adjust the pH of products; many ingredients require a specific pH to be effective.

In small amounts, sodium hydroxide is considered safe to use. However, large amounts may cause chemical burns due to its high alkaline.

Your skin has a natural pH and acid mantle. This acid mantle helps prevent harmful bacteria from breaking through. The acid mantle also helps keep your skin hydrated.

"Alkaline" refers to a high pH level. A low pH level would be considered acidic.

Tocopheryl Acetate is a stable, shelf-friendly form of vitamin E.

Formulators love it because plain vitamin E oxidizes quickly once it hits air. This acetate version stays stable and resists going off, helping to extend a product's shelf life.

It's actually inactive on its own and works like a slow-release "storage" form; the enzymes in your skin called esterases gradually convert it into active vitamin E over time.

One in vivo study showed 5% of the acetate in the living layer of the epidermis converted to vitamin E after 5 days of application. This study also found the skin gained protection against UV damage even though the conversion was slow and small.

Once converted, vitamin E acts as a skin's main fat-soluble antioxidant that fights free radicals to protect skin from damage.

Topical vitamin E generally boosts the skin's photoprotection, and it reduced UV-damage in animal models.

This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.

Overall, it has a pretty solid safety profile and has been found to be non-irritating and non-comedogenic. Allergic reactions may happen but stay rare due to how widely the ingredient gets used.

The concentration will vary depending on the formula; industry data shows 0.1% in baby lotions, 3% in lipsticks, and 5% in foot powders. You can also find this ingredient at 100% in a pure vitamin E oil.

Most leave-on skincare keeps it at the lower end, often between 0.5-1%.

Trehalose is a disaccharide made of two glucose molecules (glucose is sugar!). Trehalose is used to help moisturize skin. It also has antioxidant properties.

As a humectant, trehalose helps draw moisture from the air to your skin. This helps keep your skin hydrated.

Due to its antioxidant properties, trehalose may help with signs of aging. Antioxidants help fight free-radical molecules, unstable molecules that may damage your skin.

In medicine, trehalose and hyaluronic acid are used to help treat dry eyes.

Some animals, plants, and bacteria create trehalose as a source of energy to survive freeze or lack of water.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Similar Comparisons

The reference edit

Ingredients, questions
& further reading.

Connected source records selected through this article’s public topic index.

02

Product index

Related product references

03

Comparison edit

Read side by side