Hada Labo Premium Hydrating Lotion Versus Isntree Ultra-Low Molecular Hyaluronic Acid Serum

Hada Labo Premium Hydrating Lotion Versus Isntree Ultra-Low Molecular Hyaluronic Acid Serum

This hydrating toner is formulated around Niacinamide and Sodium Hyaluronate to hydrate skin and strengthen the skin barrier.

This hydrating serum is formulated around Panthenol and Hydrolyzed Hyaluronic Acid to hydrate skin and strengthen the skin barrier.

What's inside

Key Ingredients

Benefits

Ingredients Side-by-side

Water

Glycerin

Dipropylene Glycol

Niacinamide

Hydroxyethyl Urea

Pentylene Glycol

PEG/PPG-17/6 Copolymer

PEG-32

Triethyl Citrate

Methyl Gluceth-10

1,2-Hexanediol

Butylene Glycol

Trehalose

Hydroxyacetophenone

Carbomer

Diethoxyethyl Succinate

PEG-75

Maltooligosyl Glucoside

Disodium Succinate

Sodium Hyaluronate

Hydrogenated Starch Hydrolysate

Potassium Hydroxide

Lactobacillus/Soybean Ferment Extract

Viscum Album Leaf Extract

Succinic Acid

Disodium EDTA

Imperata Cylindrica Root Extract

Hydrolyzed Sodium Hyaluronate

C12-13 Alkyl Glyceryl Hydrolyzed Hyaluronate

Phenylethyl Resorcinol

Hydrolyzed Collagen

Copper Tripeptide-1

Sodium Acetylated Hyaluronate

Caprylyl Glycol

Polyquaternium-51

Sodium Hyaluronate Crosspolymer

Lactococcus/Hyaluronic Acid Ferment Filtrate

Acetyl Hexapeptide-8

Aphanothece Sacrum Polysaccharide

Silica

Water, Glycerin, Dipropylene Glycol, Niacinamide, Hydroxyethyl Urea, Pentylene Glycol, PEG/PPG-17/6 Copolymer, PEG-32, Triethyl Citrate, Methyl Gluceth-10, 1,2-Hexanediol, Butylene Glycol, Trehalose, Hydroxyacetophenone, Carbomer, Diethoxyethyl Succinate, PEG-75, Maltooligosyl Glucoside, Disodium Succinate, Sodium Hyaluronate, Hydrogenated Starch Hydrolysate, Potassium Hydroxide, Lactobacillus/Soybean Ferment Extract, Viscum Album Leaf Extract, Succinic Acid, Disodium EDTA, Imperata Cylindrica Root Extract, Hydrolyzed Sodium Hyaluronate, C12-13 Alkyl Glyceryl Hydrolyzed Hyaluronate, Phenylethyl Resorcinol, Hydrolyzed Collagen, Copper Tripeptide-1, Sodium Acetylated Hyaluronate, Caprylyl Glycol, Polyquaternium-51, Sodium Hyaluronate Crosspolymer, Lactococcus/Hyaluronic Acid Ferment Filtrate, Acetyl Hexapeptide-8, Aphanothece Sacrum Polysaccharide, Silica

Sea Water

Methylpropanediol

Betaine

Allantoin

Tromethamine

Ethylhexylglycerin

Xanthan Gum

Panthenol

Malachite Extract

Hydrolyzed Hyaluronic Acid

Glyceryl Acrylate/Acrylic Acid Copolymer

Glyceryl Glucoside

Potassium Hyaluronate

Hyaluronic Acid

Hydroxypropyltrimonium Hyaluronate

Dimethylsilanol Hyaluronate

Hydrolyzed Calcium Hyaluronate

Sodium Sulfated Hyaluronate

Madecassoside

Beta-Glucan

Sodium Stearoyl Hyaluronate

Sodium Oleoyl Hyaluronate

Sea Water, Water, Methylpropanediol, Glycerin, Butylene Glycol, 1,2-Hexanediol, Betaine, Pentylene Glycol, Carbomer, Caprylyl Glycol, Allantoin, Tromethamine, Ethylhexylglycerin, Xanthan Gum, Panthenol, Malachite Extract, Hydrolyzed Hyaluronic Acid, Disodium EDTA, Glyceryl Acrylate/Acrylic Acid Copolymer, Glyceryl Glucoside, Sodium Hyaluronate, Potassium Hyaluronate, Hyaluronic Acid, Hydrolyzed Sodium Hyaluronate, Sodium Acetylated Hyaluronate, Hydroxypropyltrimonium Hyaluronate, Sodium Hyaluronate Crosspolymer, Dimethylsilanol Hyaluronate, Hydrolyzed Calcium Hyaluronate, Sodium Sulfated Hyaluronate, Madecassoside, Beta-Glucan, Sodium Stearoyl Hyaluronate, Sodium Oleoyl Hyaluronate

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.

It is a:

Humectant, drawing moisture into the skin

Emollient, helping to soften skin

Solvent, dispersing and stabilizing formulas

Preservative booster, enhancing the antimicrobial activity of other preservatives

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.

Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.

Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).

Carbomer is a synthetic thickening and gelling agent. It's basically the ingredient that gives a lot of serums, gels, creams, and sunscreens their smooth, non-sticky texture.

Although legally permitted at very high levels, carbomers are normally used at concentrations below 1%.

It also needs to be neutralized to actually thicken, and because it is a large molecule, it doesn't really penetrate the skin barrier.

Allergy-wise, the risk is very low. Clinical studies show carbomers have low potential for skin irritation/sensitization even at concentrations up to 100%.

A 2024 UK study patch-tested 1,302 patients and found true allergy to the parent group of carbomer to be rare with no confirmed relevant reactions.

Disodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air.

This ingredient mainly works behind the scenes and helps with:

On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it.

One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin).

Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption.

You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

This ingredient is created by putting sodium hyaluronate through hydrolysis.

You might know this as 'mini' or 'ultra low-molecular weight' hyaluronic acid. The small molecule size means it is able to travel deeper in the skin.

According to studies, low molecular-weight hyaluronic acid can:

One study from 2011 found ultra-low weight HA to show pro-inflammatory properties. Another study from 2022 found it to downregulate UV-B induced inflammation.

Hydrolysis is a process of changing a molecule using water or enzymes.

This ingredient is water-soluble.

Pentylene Glycol (1,2-pentanediol) is a multitasking little diol with three main roles in a formula:

Research on alkanediols (the family pentylene glycol belongs to) show they work by disrupting microbial cell membranes. This disruption helps the primary preservative system in a product work more effectively at lower doses.

On the safety side, the Cosmetic Ingredient Review Expert Panel has concluded this ingredient to be safe as used in current cosmetic practices + concentrations.

Typical use levels in a formula run about 1-5%.

Sodium Acetylated Hyaluronate is a type of Hyaluronic Acid.

Hyaluronic Acids help moisturize, soothe, and protect the skin.

Read about common types of Hyaluronic Acid here:

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Sodium Hyaluronate Crosspolymer is a crosslinked version of sodium hyaluronate. This just means it's linked into a 3D mesh network that lets it be more stable and sit on skin as a cohesive, gel-like film rather than sinking into skin.

A 2016 human skin study found crosslinked HA increased epidermal water content by 7.6% over the control group and reduced transepidermal water loss by 27.8%.

A follow-up clinical trial found that a topical crosslinked HA serum applied after fillers, microneedling, or chemical peels was well-tolerated and enhanced skin quality at 14 / 28 days.

More recent research suggests that concentrations as low as 0.03% can act as a penetration enhancer for other skincare actives.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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