ISOI Blemish Care Eye & Wrinkle Patch Versus MEDI-PEEL Hyaluron Dark Benone Peptide 9 Ampoule Eye Patch

ISOI Blemish Care Eye & Wrinkle Patch Versus MEDI-PEEL Hyaluron Dark Benone Peptide 9 Ampoule Eye Patch

This brightening eye mask is formulated around Niacinamide and Rosa Damascena Flower Water to fade the look of dark spots and soften the look of wrinkles.

This anti-aging eye mask is formulated around Sodium Hyaluronate and Acetyl Hexapeptide-8 to soften the look of wrinkles and hydrate skin.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Dipropylene Glycol

Glycerin

Niacinamide

1,2-Hexanediol

Chondrus Crispus Extract

Rosa Damascena Flower Water

Ceratonia Siliqua Gum

Rosa Damascena Flower Oil

Rosa Hybrid Flower

Sodium Hyaluronate

Sodium Acetylated Hyaluronate

Hydrolyzed Hyaluronic Acid

Hydrolyzed Sodium Hyaluronate

Hyaluronic Acid

Hydroxypropyltrimonium Hyaluronate

Potassium Hyaluronate

Sodium Hyaluronate Crosspolymer

Hippophae Rhamnoides Fruit Extract

Rubus Idaeus Fruit Extract

Rubus Fruticosus Fruit Extract

Euterpe Oleracea Fruit Extract

Vaccinium Myrtillus Fruit Extract

Vaccinium Macrocarpon Fruit Extract

Ribes Nigrum Fruit Extract

Vaccinium Angustifolium Fruit Extract

Houttuynia Cordata Extract

Centella Asiatica Extract

Calendula Officinalis Flower Extract

Scutellaria Baicalensis Root Extract

Glycyrrhiza Glabra Root Extract

Glutathione

Allantoin

Betaine

Trehalose

Panthenol

Dipotassium Glycyrrhizate

Adenosine

Potassium Chloride

Sucrose

Xanthan Gum

Cellulose Gum

Polyglyceryl-10 Oleate

Glyceryl Caprylate

Pelargonium Graveolens Flower Oil

Citrus Aurantium Dulcis Peel Oil

Citronellol

Geraniol

Linalool

CI 77491

Water, Dipropylene Glycol, Glycerin, Niacinamide, 1,2-Hexanediol, Chondrus Crispus Extract, Rosa Damascena Flower Water, Ceratonia Siliqua Gum, Rosa Damascena Flower Oil, Rosa Hybrid Flower, Sodium Hyaluronate, Sodium Acetylated Hyaluronate, Hydrolyzed Hyaluronic Acid, Hydrolyzed Sodium Hyaluronate, Hyaluronic Acid, Hydroxypropyltrimonium Hyaluronate, Potassium Hyaluronate, Sodium Hyaluronate Crosspolymer, Hippophae Rhamnoides Fruit Extract, Rubus Idaeus Fruit Extract, Rubus Fruticosus Fruit Extract, Euterpe Oleracea Fruit Extract, Vaccinium Myrtillus Fruit Extract, Vaccinium Macrocarpon Fruit Extract, Ribes Nigrum Fruit Extract, Vaccinium Angustifolium Fruit Extract, Houttuynia Cordata Extract, Centella Asiatica Extract, Calendula Officinalis Flower Extract, Scutellaria Baicalensis Root Extract, Glycyrrhiza Glabra Root Extract, Glutathione, Allantoin, Betaine, Trehalose, Panthenol, Dipotassium Glycyrrhizate, Adenosine, Potassium Chloride, Sucrose, Xanthan Gum, Cellulose Gum, Polyglyceryl-10 Oleate, Glyceryl Caprylate, Pelargonium Graveolens Flower Oil, Citrus Aurantium Dulcis Peel Oil, Citronellol, Geraniol, Linalool, CI 77491

Carrageenan

Butylene Glycol

Hydrolyzed Collagen

Pearl Extract

Polysorbate 80

Tocopheryl Acetate

Ubiquinone

Acetyl Hexapeptide-8

Copper Tripeptide-1

Oligopeptide-29

Oligopeptide-32

Palmitoyl Pentapeptide-4

Palmitoyl Tripeptide-1

Palmitoyl Tetrapeptide-7

Glyceryl Polymethacrylate

Propylene Glycol

Palmitoyl Oligopeptide

Palmitoyl Tripeptide-5

Propanediol

Pentylene Glycol

Cocos Nucifera Fruit Extract

Pinus Sylvestris Leaf Extract

Ricinus Communis Seed Oil

Butyrospermum Parkii Butter

Cyamopsis Tetragonoloba Gum

Calcium Chloride

Calcium Lactate

Caprylic/Capric Triglyceride

Sorbitan Caprylate

PEG-60 Hydrogenated Castor Oil

Diamond Powder

Titanium Dioxide

Oleth-10

Triethoxycaprylylsilane

Polysorbate 60

Simethicone

Methyl Methacrylate Crosspolymer

Aluminum Hydroxide

Synthetic Fluorphlogopite

Arginine

Disodium EDTA

Chlorphenesin

Ethyl Hexanediol

Ethylhexylglycerin

Parfum

Water, Glycerin, Carrageenan, Butylene Glycol, Hydrolyzed Collagen, Sodium Hyaluronate, Hydrolyzed Hyaluronic Acid, Sodium Acetylated Hyaluronate, Hydroxypropyltrimonium Hyaluronate, Potassium Hyaluronate, Sodium Hyaluronate Crosspolymer, Hyaluronic Acid, Pearl Extract, Polysorbate 80, Tocopheryl Acetate, Ubiquinone, Acetyl Hexapeptide-8, Copper Tripeptide-1, Oligopeptide-29, Oligopeptide-32, Palmitoyl Pentapeptide-4, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Glyceryl Polymethacrylate, Propylene Glycol, Palmitoyl Oligopeptide, Palmitoyl Tripeptide-5, Propanediol, Pentylene Glycol, Cocos Nucifera Fruit Extract, Pinus Sylvestris Leaf Extract, Ricinus Communis Seed Oil, Butyrospermum Parkii Butter, Betaine, Allantoin, Dipotassium Glycyrrhizate, Ceratonia Siliqua Gum, Sucrose, Cyamopsis Tetragonoloba Gum, Cellulose Gum, Potassium Chloride, Calcium Chloride, Calcium Lactate, Caprylic/Capric Triglyceride, Sorbitan Caprylate, PEG-60 Hydrogenated Castor Oil, Diamond Powder, Titanium Dioxide, Oleth-10, Triethoxycaprylylsilane, Polysorbate 60, Simethicone, Methyl Methacrylate Crosspolymer, Aluminum Hydroxide, Synthetic Fluorphlogopite, Arginine, Disodium EDTA, Chlorphenesin, Ethyl Hexanediol, 1,2-Hexanediol, Ethylhexylglycerin, Parfum

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Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.

It is a:

Humectant, drawing moisture into the skin

Emollient, helping to soften skin

Solvent, dispersing and stabilizing formulas

Preservative booster, enhancing the antimicrobial activity of other preservatives

Allantoin is a soothing ingredient known for its protective and moisturizing properties; it's basically a quiet workhorse ingredient you can find in a huge range of cosmetics.

Though it can be derived from the comfrey plant, allantoin is produced synthetically for cosmetic products to ensure purity.

Research shows it can encourage your skin cells to turn over and renew by stimulating keratinocyte and fibroblast proliferation.

It also has mild keratolytic properties to help loosen and shed dead skin cells without being harsh.

Studies also suggest allantoin can help calm inflammation by dialing down some of the chemical signals your skin sends out when it is irritated.

This ingredient is typically used in the 0.1-0.5% range, and the FDA recognizes it as a skin protectant in OTC products up to 2%.

Overall, allantoin is a wonderful addition to most routines; it is stable across a wide pH range (~4-8), works well with other ingredients, and is considered non-sensitizing/non-irritating.

Fun fact: Allantoin is naturally occurring in comfrey root, beets, chamomile, and wheat sprouts. Our bodies even produce it as a byproduct of uric acid metabolism.

Betaine is a humectant. Like hyaluronic acid, it helps attract and retain moisture in the skin. It’s known for being gentle and for helping the skin maintain balanced hydration.

Betaine is mainly used to improve hydration and support calmer skin. It helps skin cells regulate water balance because it functions as an osmolyte.

Some studies suggest betaine may support making skin tone more even.

Fun fact: Betaine naturally exists in the skin and the body. In cosmetic products, it can be either plant-derived (most commonly from sugar beets) or synthetically produced for consistency and stability.

Betaine is also known as trimethylglycine.

Cellulose Gum is a water-soluble polymer that comes from cellulose. It is used to change the texture of a product and to help stabilize emulsions.

As an emulsifier, cellulose gum specifically thicken the texture of water-based products.

This ingredient is considered hypoallergenic and non-toxic. Cellulose Gum can be found in cosmetics, food, and other household goods such as paper products.

Ceratonia Siliqua Gum is extracted from the seeds of the carob tree. You might know this ingredient as Carob Gum or Locust Bean Gum. It is used to stabilize other ingredients and improve the texture of products.

Carob gum is made up of long-chain polysaccharides. This makes it a natural thickener.

Yes! This ingredient comes from the seeds of a tree. The name 'Locust Bean Gum' can be misleading.

Dipotassium Glycyrrhizate comes from licorice root.

Extracts of licorice have demonstrated to have antibacterial, anti‐inflammatory, antiviral, antioxidant properties.

One component, glabridin, has extra potent antioxidant and soothing properties. It has also been found to block pigmentation from UVB rays in guinea pigs.

Licorice Root also contains a flavonoid. Flavonoids are a natural substance from in plants. Flavonoids also have antioxidant properties.

Another component, glycyrrhizin, has been found to have anti-inflammatory and antimicrobial benefits. This may make licorice root extract effective at treating acne. However, more research is needed to support this.

Liquiritin is one of the flavone compounds found in licorice. It has been found to help lighten skin by preventing tyrosinase from reacting with tyrosine. When the two react, protein is converted to melanin. Melanin is the substance in your body that gives your features pigmentation.

Licorice root is native to Southern Europe and Asia. It has been used in traditional Chinese medicine to help with respiratory issues.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Hyaluronic acid (HA) is a glycosaminoglycan (basically a long sugar chain) that your skin already makes on its own. In your skin, HA lives in the extracellular matrix and acts as the body's moisture reservoir.

Topically, HA is a humectant that binds water and helps skin look more plump, smooth, and hydrated.

The only catch is that HA isn't a single thing; it actually comes in a wide range of molecular weights (~50 - 2,000+ kDA) and size matters.

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

This is why the best HA serums blend the two sizes together so you get the best of both worlds.

The majority of cosmetic HA is produced by bacterial fermentation, typically using Streptococcus or Bacillus strains. Typical use levels in skincare sit around 0.1-2%.

A clinical study using a 0.2% low-molecular weight HA gel showed improvement in facial seborrheic dermatitis with excellent tolerance.

These are some other common types of Hyaluronic Acid:

Hydrolyzed Hyaluronic Acid is hyaluronic acid (HA) that is broken down into lower molecular weight fragments.

It's a humectant that pulls and holds water in the skin to help with hydration, plumpness, and reduce transepidermal water loss.

Because hydrolyzed hyaluronic acid is smaller in size, it can slip past your outermost layer of skin more easily than full-sized HA.

Most formulations will combine all sizes to get the best of both worlds.

Typical usage levels range from 0.01-1%. Any percentage higher than 2% might become goopy and tacky.

Hydroxypropyltrimonium Hyaluronate is a positively charged version of hyaluronic acid.

This small change does a lot in a formula:

Regular hyaluronic acid carries a negative charge and so does the surface of your skin. This means the two repel each other and hyaluronic acid can be washed away easily. The positive charge here does the opposite: it makes the ingredient cling to your skin (also called "substantivity") so it keeps hydrating even in rinse-off products where it lays down a light, moisture-holding film.

The research backs this up too; a 2025 clinical study on a shower gel containing 0.1% positively charged hyaluronic acid increased skin hydration by 6.6% versus the baseline and 11.1% versus the placebo. This was measured 6 hours after 1 minute of contact and rinse, and on volunteers with very dry skin.

The same team's lab work showed it adhered to skin far better than unmodified hyaluronic acid (+107% vs. low molecular weight, +23% versus high molecular weight). They also found it increased two proteins tied to skin hydration, aquaporin-3 by 16% and filaggrin by 35%.

A separate 2024 study reached a similar conclusion and credited the hydrating benefits to its film-forming properties.

Both studies used the ingredient at 0.1% which also matches how much it usually shows up in products (at fractions of a percent).

One honesty note worth keeping in mind: the published research comes from the company that manufactures the ingredient so independent data would strengthen the picture. However, the results are consistent and the mechanism makes sense.

As a Hyaluronic Acid derivative, it has a well-tolerated profile and suits most skin types.

We don't have a description for Potassium Chloride yet.

Potassium hyaluronate (PH) is a salt form of hyaluronic acid and has similar skin hydrating benefits.

Similar to hyaluronic acid, PH is able to draw and hold moisture to your skin. This helps keep skin soft and hydrated.

Fun fact: PH is used in eye drops and injectable treatments for joint disorders. It has lubricating and tissue-repair properties.

Sodium Acetylated Hyaluronate is a type of Hyaluronic Acid.

Hyaluronic Acids help moisturize, soothe, and protect the skin.

Read about common types of Hyaluronic Acid here:

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Sodium Hyaluronate Crosspolymer is a crosslinked version of sodium hyaluronate. This just means it's linked into a 3D mesh network that lets it be more stable and sit on skin as a cohesive, gel-like film rather than sinking into skin.

A 2016 human skin study found crosslinked HA increased epidermal water content by 7.6% over the control group and reduced transepidermal water loss by 27.8%.

A follow-up clinical trial found that a topical crosslinked HA serum applied after fillers, microneedling, or chemical peels was well-tolerated and enhanced skin quality at 14 / 28 days.

More recent research suggests that concentrations as low as 0.03% can act as a penetration enhancer for other skincare actives.

Sucrose is a natural sugar found in fruits, vegetables, and nuts. It is the main constituent of white sugar.

In skincare, sucrose is a humectant and can be a mild exfoliant.

Sucrose is hydrophilic, meaning it attracts water. This makes it an effective humectant and helps hydrate the skin.

Studies show sugars may worsen acne-prone skin due to it disrupting the skin's natural biome. We recommend speaking with a professional if you have any concerns.

In some products such as body scrubs, sucrose is used as an gentle exfoliant.

The term 'sucrose' comes from the french word for sugar, 'sucre'.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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