Le Mieux TGF-B Booster Versus G.M. Collin 4D Visible Lifting Serum

Le Mieux TGF-B Booster Versus G.M. Collin 4D Visible Lifting Serum

This anti-aging serum is formulated around Hyaluronic Acid and Palmitoyl Tetrapeptide-7 to soften the look of wrinkles and hydrate skin.

This anti-aging serum is formulated around Sodium Hyaluronate and Palmitoyl Tetrapeptide-7 to soften the look of wrinkles and hydrate skin.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Hyaluronic Acid

Hydrolyzed Sodium Hyaluronate

Sodium Hyaluronate

Sodium Hyaluronate Crosspolymer

Hydroxypropyltrimonium Hyaluronate

C12-13 Alkyl Glyceryl Hydrolyzed Hyaluronate

Superoxide Dismutase

Saccharomyces Polypeptides

Palmitoyl Tetrapeptide-7

Palmitoyl Tripeptide-5

Palmitoyl Tripeptide-1

Acetyl Octapeptide-3

Ceramide Ns

Saccharomyces/Copper Ferment

Saccharomyces/Zinc Ferment

Saccharomyces/Manganese Ferment

Riboflavin

Phospholipids

Folic Acid

Enteromorpha Compressa Extract

Glycoproteins

Ginkgo Biloba Leaf Extract

Serine

Proline

Alanine

Glutamic Acid

Niacinamide

Parfum

Caprylyl Glycol

Ethylhexylglycerin

Undecylenoyl Glycine

Capryloyl Glycine

Hyaluronic Acid, Hydrolyzed Sodium Hyaluronate, Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Hydroxypropyltrimonium Hyaluronate, C12-13 Alkyl Glyceryl Hydrolyzed Hyaluronate, Superoxide Dismutase, Saccharomyces Polypeptides, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-5, Palmitoyl Tripeptide-1, Acetyl Octapeptide-3, Ceramide Ns, Saccharomyces/Copper Ferment, Saccharomyces/Zinc Ferment, Saccharomyces/Manganese Ferment, Riboflavin, Phospholipids, Folic Acid, Enteromorpha Compressa Extract, Glycoproteins, Ginkgo Biloba Leaf Extract, Serine, Proline, Alanine, Glutamic Acid, Niacinamide, Parfum, Caprylyl Glycol, Ethylhexylglycerin, Undecylenoyl Glycine, Capryloyl Glycine

Water

Hydrolyzed Glycosaminoglycans

Hydrolyzed Manihot Esculenta Tuber Extract

Butylene Glycol

Glycerin

Glyceryl Acrylate/Acrylic Acid Copolymer

Acrylic Acid

Laureth-23

Dimethicone

Dextran

Trifluoroacetyl Tripeptide-2

Carbomer

Polysorbate 20

Palmitoyl Oligopeptide

Propanediol

Ornithine

Glycolipids

Hydrolyzed Soy Flour

Dimer Tripeptide-43

Sorbitol

Yeast Extract

PEG-40 Hydrogenated Castor Oil

Sodium Polyacrylate

Potassium Sorbate

Phenoxyethanol

Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate

CI 15985

CI 17200

Water, Sodium Hyaluronate, Hydrolyzed Glycosaminoglycans, Hydrolyzed Manihot Esculenta Tuber Extract, Butylene Glycol, Glycerin, Glyceryl Acrylate/Acrylic Acid Copolymer, Acrylic Acid, Laureth-23, Dimethicone, Dextran, Trifluoroacetyl Tripeptide-2, Carbomer, Polysorbate 20, Palmitoyl Oligopeptide, Palmitoyl Tetrapeptide-7, Propanediol, Ornithine, Phospholipids, Glycolipids, Hydrolyzed Soy Flour, Dimer Tripeptide-43, Sorbitol, Yeast Extract, PEG-40 Hydrogenated Castor Oil, Ethylhexylglycerin, Sodium Polyacrylate, Potassium Sorbate, Phenoxyethanol, Parfum, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, CI 15985, CI 17200

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Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Palmitoyl Tetrapeptide-7 (formerly Palmitoyl Tetrapeptide-3) is a synthetic peptide. Its main job is to fight what researchers call "inflammaging".

"Inflammaging" is the slow, low-grade chronic inflammation that quietly breaks down collagen as we age.

This ingredient calms down a specific inflammation signal in your skin cells (called IL-6). When left unchecked, this signal triggers enzymes that break down collagen and elastin.

Clinical testing showed statistically significant improvements in:

Studies also found the more of this ingredient used, the more your skin produces Collagen I, fibronectin, and hyaluronic acid.

You'll likely see this ingredient paired with Palmitoyl Tripeptide-1 in the well-known Matrixyl 3000 complex for enhanced anti-aging effects.

A 3% concentration applied twice daily for two months showed meaningful skin rejuvenation results in clinical panels.

Fungal acne note: Usually a palmitic acid component can feed Malassezia in unbound form, but here is is covalently bonded to the peptide. This means it is very difficult for Malassezia to access, and therefore very unlikely to cause fungal acne.

Parfum is a catch-all term for an ingredient or more that is used to give a scent to products.

Also called "fragrance", this ingredient can be a blend of hundreds of chemicals or plant oils. This means every product with "fragrance" or "parfum" in the ingredients list is a different mixture.

For instance, Habanolide is a proprietary trade name for a specific aroma chemical. When used as a fragrance ingredient in cosmetics, most aroma chemicals fall under the broad labeling category of “FRAGRANCE” or “PARFUM” according to EU and US regulations.

The term 'parfum' or 'fragrance' is not regulated in many countries. In many cases, it is up to the brand to define this term.

For instance, many brands choose to label themselves as "fragrance-free" because they are not using synthetic fragrances. However, their products may still contain ingredients such as essential oils that are considered a fragrance by INCI standards.

One example is Calendula flower extract. Calendula is an essential oil that still imparts a scent or 'fragrance'.

Depending on the blend, the ingredients in the mixture can cause allergies and sensitivities on the skin. Some ingredients that are known EU allergens include linalool and citronellol.

Parfum can also be used to mask or cover an unpleasant scent.

The bottom line is: not all fragrances/parfum/ingredients are created equally. If you are worried about fragrances, we recommend taking a closer look at an ingredient. And of course, we always recommend speaking with a professional.

Phospholipids are a family of skin-identical lipids that makeup the structural backbone of every cell membrane in your body.

In cosmetics, they function as skin conditioning agents with emulsifier and surfactant properties. They're typically sourced from soybean or sunflower lecithin (or sometimes egg yolk or marine sources).

Because they mirror the lipids naturally found in the deeper layers of your skin, topical phospholipids help reinforce the lipid matrix, reduce transepidermal water loss, and leave skin feeling conditioned.

They're also used to form liposomes, or tiny self-assembling vesible used to stabilize actives like vitamin c or retinol. This helps these ingredients integrate into the upper layers of skin more easily.

Phospholipids are compatible with everything and the CIR Expert Panel has concluded them to be safe at current use levels.

Some types of phospholipids include:

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

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