Skin science article
Missha Vita C Plus Spot Correcting & Firming Ampoule Versus Paula's Choice 10% Niacinamide Booster
Missha Vita C Plus Spot Correcting & Firming Ampoule Versus Paula's Choice 10% Niacinamide Booster This brightening ampoule is formulated around Niacinamide and 3-O-Ethyl Ascorbic Acid to fade the look of dark spots and soften the look of wrinkles. This pore-c
Missha Vita C Plus Spot Correcting & Firming Ampoule Versus Paula's Choice 10% Niacinamide Booster
This brightening ampoule is formulated around Niacinamide and 3-O-Ethyl Ascorbic Acid to fade the look of dark spots and soften the look of wrinkles.
This pore-care treatment is formulated around Niacinamide and Acetyl Glucosamine to refine the look of pores and refine skin texture.
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Glycyrrhiza Uralensis Root Extract
Hippophae Rhamnoides Water
Glycerin
Methylpropanediol
Butylene Glycol
Niacinamide
Diethoxyethyl Succinate
1,2-Hexanediol
Tocopheryl Acetate
Water
3-O-Ethyl Ascorbic Acid
Bifida Ferment Lysate
Tranexamic Acid
Sodium Polyacryloyldimethyl Taurate
Chlorella Vulgaris Extract
Glucose
Caprylic/Capric Triglyceride
Glycine Soja Oil
Fructooligosaccharides
Fructose
Arbutin
Hydrogenated Lecithin
Panthenol
Citrus Aurantium Dulcis Peel Oil
Xanthan Gum
Adenosine
Ethylhexylglycerin
Citric Acid
Polyquaternium-51
Ceramide NP
Citrus Grandis Peel Oil
Sodium Phytate
Eucalyptus Globulus Leaf Oil
Lavandula Angustifolia Oil
Sodium Citrate
Daucus Carota Sativa Root Extract
Beta-Carotene
Tocopherol
Hydrolyzed Collagen
Allantoin
Glyceryl Glucoside
Dipropylene Glycol
Palmitoyl Tripeptide-5
Caprylyl Glycol
Ascorbic Acid
Hyaluronic Acid
Acetyl Hexapeptide-8
Pentylene Glycol
Pvp
Laurdimonium Hydroxypropyl Hydrolyzed Wheat Protein
Hydrolyzed Hyaluronic Acid
Sodium Hyaluronate
Phytosterols
Ascorbyl Glucoside
Fullerenes
Limonene
Linalool
Glycyrrhiza Uralensis Root Extract, Hippophae Rhamnoides Water, Glycerin, Methylpropanediol, Butylene Glycol, Niacinamide, Diethoxyethyl Succinate, 1,2-Hexanediol, Tocopheryl Acetate, Water, 3-O-Ethyl Ascorbic Acid, Bifida Ferment Lysate, Tranexamic Acid, Sodium Polyacryloyldimethyl Taurate, Chlorella Vulgaris Extract, Glucose, Caprylic/Capric Triglyceride, Glycine Soja Oil, Fructooligosaccharides, Fructose, Arbutin, Hydrogenated Lecithin, Panthenol, Citrus Aurantium Dulcis Peel Oil, Xanthan Gum, Adenosine, Ethylhexylglycerin, Citric Acid, Polyquaternium-51, Ceramide NP, Citrus Grandis Peel Oil, Sodium Phytate, Eucalyptus Globulus Leaf Oil, Lavandula Angustifolia Oil, Sodium Citrate, Daucus Carota Sativa Root Extract, Beta-Carotene, Tocopherol, Hydrolyzed Collagen, Allantoin, Glyceryl Glucoside, Dipropylene Glycol, Palmitoyl Tripeptide-5, Caprylyl Glycol, Ascorbic Acid, Hyaluronic Acid, Acetyl Hexapeptide-8, Pentylene Glycol, Pvp, Laurdimonium Hydroxypropyl Hydrolyzed Wheat Protein, Hydrolyzed Hyaluronic Acid, Sodium Hyaluronate, Phytosterols, Ascorbyl Glucoside, Fullerenes, Limonene, Linalool
Acetyl Glucosamine
Phospholipids
Boerhavia Diffusa Root Extract
Dipotassium Glycyrrhizate
Glycyrrhiza Glabra Root Extract
Ubiquinone
Epigallocatechin Gallate
Beta-Glucan
Carnosine
Genistein
Sodium Hydroxide
Disodium EDTA
Phenoxyethanol
Water, Niacinamide, Acetyl Glucosamine, Ascorbyl Glucoside, Butylene Glycol, Phospholipids, Sodium Hyaluronate, Allantoin, Boerhavia Diffusa Root Extract, Glycerin, Dipotassium Glycyrrhizate, Glycyrrhiza Glabra Root Extract, Ubiquinone, Epigallocatechin Gallate, Beta-Glucan, Panthenol, Carnosine, Genistein, Citric Acid, Sodium Citrate, Sodium Hydroxide, Xanthan Gum, Disodium EDTA, Ethylhexylglycerin, Phenoxyethanol
Reviews
Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Allantoin is a soothing ingredient known for its protective and moisturizing properties; it's basically a quiet workhorse ingredient you can find in a huge range of cosmetics.
Though it can be derived from the comfrey plant, allantoin is produced synthetically for cosmetic products to ensure purity.
Research shows it can encourage your skin cells to turn over and renew by stimulating keratinocyte and fibroblast proliferation.
It also has mild keratolytic properties to help loosen and shed dead skin cells without being harsh.
Studies also suggest allantoin can help calm inflammation by dialing down some of the chemical signals your skin sends out when it is irritated.
This ingredient is typically used in the 0.1-0.5% range, and the FDA recognizes it as a skin protectant in OTC products up to 2%.
Overall, allantoin is a wonderful addition to most routines; it is stable across a wide pH range (~4-8), works well with other ingredients, and is considered non-sensitizing/non-irritating.
Fun fact: Allantoin is naturally occurring in comfrey root, beets, chamomile, and wheat sprouts. Our bodies even produce it as a byproduct of uric acid metabolism.
Ascorbyl Glucoside (AA-2G) is one of the most stable vitamin C derivatives out there.
It's made by attaching a glucose molecule to ascorbic acid; this glucose "cap" shields the vitamin C from air, light, heat, and metal ions that normally cause pure ascorbic acid to oxidize.
Once on your skin, the enzyme alpha-glucosidase snips off the glucose and gradually releases active ascorbic acid right where it's needed. Basically, it behaves like a slow-release pro-vitamin C with less of a stinging that high-strength ascorbic acid can cause.
The research supports the classic vitamin C benefits as well. In lab and human studies, AA-2G slowed down the skin's production of melanin (the pigment behind dark spots) and helped shield skin cells against sun damage better than ascorbyl phosphate.
These studies also showed AA-2G released vitamin C over a longer period.
A frequently cited manufacturer trial found that a 2% AA-2G face cream significantly improved wrinkle depth and skin roughness after 45 days.
And in 2009, a clinical trial showed it meaningfully lightened dark patches on the gums compared to a placebo.
There's also collagen-synthesis support (since vitamin C is a required cofactor for that) and an antioxidant effect too.
Typical usage is usually between 0.5-5% and most studies/products land around 2%.
AA-2G performs best when formulated at a mildly acidic pH (~5-7) which is much gentler than the pH that pure vitamin C demands (~2.5-3.5).
Just one thing worth knowing: the in-skin conversation rate is only about 55-60% by weight. So a 5% AA-2G product delivers roughly 2.75-3% of actual active vitamin C. On top of that, skin absorption is relatively low because the ingredient is water-soluble.
Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
Citric Acid is an alpha hydroxy acid (AHA) naturally found in citrus fruits like oranges, lemons, and limes.
Like other AHAs, citric acid can exfoliate skin by breaking down the bonds that hold dead skin cells together. This helps reveal smoother and brighter skin underneath.
However, this exfoliating effect only happens at high concentrations (20%) which can be hard to find in cosmetic products.
Due to this, citric acid is usually included in small amounts as a pH adjuster. This helps keep products slightly more acidic and compatible with skin's natural pH.
In skincare formulas, citric acid can:
While it can provide some skin benefits, research shows lactic acid and glycolic acid are generally more effective and less irritating exfoliants.
Most citric acid used in skincare today is made by fermenting sugars (usually from molasses). This synthetic version is identical to the natural citrus form but easier to stabilize and use in formulations.
Rosacea skin has a lower threshold for acids generally, with 62.5% of rosacea subjects in one study reacting to lactic acid in a sting test. This is why we mark citric acid as a potential rosacea trigger.
However, this ingredient shows up as a pH adjuster or chelator at roughly 0.1-1% in many products. These low levels are unlikely to be an issue for rosacea skin and becomes a potential trigger at exfoliating concentrations (20%). Because everybody's skin is unique, we recommend a patch test if you are unsure.
Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:
The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.
Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.
Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Niacinamide is a multitasking form of vitamin B3 that strengthens the skin barrier, reduces pores and dark spots, regulates oil, and improves signs of aging.
And the best part? It's gentle and well-tolerated by most skin types, including sensitive and reactive skin.
You might have heard of "niacin flush", or the reddening of skin that causes itchiness. Niacinamide has not been found to cause this.
In very rare cases, some individuals may not be able to tolerate niacinamide at all or experience an allergic reaction to it.
If you are experiencing flaking, irritation, and dryness with this ingredient, be sure to double check all your products as this ingredient can be found in all categories of skincare.
When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.
When you apply niacinamide to your skin, your body converts it into nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme that is already found in your cells as "fuel" and powers countless biological processes.
In your skin, NAD helps repair cell damage, produce new healthy cells, support collagen production, strengthen the skin barrier, and fight environmental stressors (like UV and pollution).
Our natural NAD levels start to decline with age, leading to slower skin repair, visible aging, and a weaker skin barrier. By providing your skin niacinamide, you're recharging your skin's NAD levels. This leads to stronger, healthier, and younger looking skin.
Another name for vitamin B3 is nicotinamide. This vitamin is water-soluble and our bodies don't store it. We obtain Vitamin B3 from either food or skincare. Meat, fish, wheat, yeast, and leafy greens contain vitamin B3.
The type of niacinamide used in skincare is synthetically created.
Panthenol is a common ingredient that helps hydrate and soothe the skin. It is found naturally in our skin and hair.
There are two forms of panthenol: D and L.
D-panthenol is also known as dexpanthenol. Most cosmetics use dexpanthenol or a mixture of D and L-panthenol.
Panthenol is famous due to its ability to go deeper into the skin's layers. Using this ingredient has numerous pros (and no cons):
Like hyaluronic acid, panthenol is a humectant. Humectants are able to bind and hold large amounts of water to keep skin hydrated.
This ingredient works well for wound healing. It works by increasing tissue in the wound and helps close open wounds.
Once oxidized, panthenol converts to pantothenic acid. Panthothenic acid is found in all living cells.
This ingredient is also referred to as pro-vitamin B5.
Sodium Citrate is the sodium salts of citric acid. In skincare, it is used to alter pH levels and acts as a preservative.
Its main functions are to maintain the pH of a product and neutralize metal ions.
The acidity of our skin is maintained by our glands and skin biome; normal pH level of skin is slightly acidic (~4.75-5.5).
Being slightly acidic allows our skin to create an "acid mantle". This acid mantle is a thin barrier that protects our skin from bacteria and contaminants.
Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.
In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.
Interestingly, the size of the molecule affects its behavior:
Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.
Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.
You'll typically see concentrations between 0.1-2% for this ingredient.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.
On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.
Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.