Naturium Multi-Peptide Moisturizer Versus Naturium Multi-Peptide Rich Cream

Naturium Multi-Peptide Moisturizer Versus Naturium Multi-Peptide Rich Cream

This anti-aging moisturizer is formulated around Palmitoyl Tripeptide-5 and Palmitoyl Tripeptide-1 to soften the look of wrinkles.

This anti-aging moisturizer is formulated around Palmitoyl Pentapeptide-4 and Copper Tripeptide-1 to soften the look of wrinkles and strengthen the skin barrier.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Glycerin

Dimethicone

Simmondsia Chinensis Seed Oil

Squalane

Glyceryl Stearate

Cetyl Alcohol

Niacinamide

Stearyl Alcohol

Palmitoyl Tripeptide-5

Pantolactone

Palmitoyl Tripeptide-1

Palmitoyl Tetrapeptide-7

Hydrolyzed Plukenetia Volubilis Seed Extract

Dunaliella Salina Extract

Sodium Hyaluronate

3-O-Ethyl Ascorbic Acid

Panthenol

Caryodendron Orinocense Seed Oil

Honokiol

Magnolol

Palmitic Acid

Sorbitan Oleate

Aluminum Starch Octenylsuccinate

Hydroxyacetophenone

Stearic Acid

Acrylamide/Sodium Acryloyldimethyltaurate Copolymer

Polyglyceryl-6 Laurate

1,2-Hexanediol

Boron Nitride

Caprylyl Glycol

Polyglyceryl-10 Oleate

Isohexadecane

Butylene Glycol

Chlorphenesin

Acrylates/C10-30 Alkyl Acrylate Crosspolymer

Tocopheryl Acetate

Polysorbate 80

Sorbitan Palmitate

Sodium Hydroxide

Sodium Benzoate

Carbomer

Sodium Lactate

Phenoxyethanol

Polysorbate 20

Citric Acid

Ethylhexylglycerin

Potassium Sorbate

Water, Glycerin, Dimethicone, Simmondsia Chinensis Seed Oil, Squalane, Glyceryl Stearate, Cetyl Alcohol, Niacinamide, Stearyl Alcohol, Palmitoyl Tripeptide-5, Pantolactone, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Hydrolyzed Plukenetia Volubilis Seed Extract, Dunaliella Salina Extract, Sodium Hyaluronate, 3-O-Ethyl Ascorbic Acid, Panthenol, Caryodendron Orinocense Seed Oil, Honokiol, Magnolol, Palmitic Acid, Sorbitan Oleate, Aluminum Starch Octenylsuccinate, Hydroxyacetophenone, Stearic Acid, Acrylamide/Sodium Acryloyldimethyltaurate Copolymer, Polyglyceryl-6 Laurate, 1,2-Hexanediol, Boron Nitride, Caprylyl Glycol, Polyglyceryl-10 Oleate, Isohexadecane, Butylene Glycol, Chlorphenesin, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Tocopheryl Acetate, Polysorbate 80, Sorbitan Palmitate, Sodium Hydroxide, Sodium Benzoate, Carbomer, Sodium Lactate, Phenoxyethanol, Polysorbate 20, Citric Acid, Ethylhexylglycerin, Potassium Sorbate

Caprylic/Capric Triglyceride

Octyldodecanol

Polyglyceryl-3 Polyricinoleate

Cera Microcristallina

Magnesium Stearate

Polyglyceryl-3 Oleate

Undecane

Polyglyceryl-20 Octadecabehenate/Laurate

Sorbitan Olivate

Stearalkonium Bentonite

Magnesium Sulfate

Linum Usitatissimum Seed Extract

Mannitol

Phosphatidylcholine

Palmitoyl Pentapeptide-4

Copper Tripeptide-1

Ferulic Acid

Gold

Tocopherol

Tridecane

Asiaticoside

Propylene Carbonate

Glyceryl Caprylate

Decyl Glucoside

P-Anisic Acid

Xanthan Gum

Sodium Chloride

Water, Caprylic/Capric Triglyceride, Glycerin, Octyldodecanol, Butylene Glycol, Polyglyceryl-3 Polyricinoleate, Cera Microcristallina, Magnesium Stearate, Polyglyceryl-3 Oleate, Undecane, 1,2-Hexanediol, Polyglyceryl-20 Octadecabehenate/Laurate, Sorbitan Olivate, Stearalkonium Bentonite, Magnesium Sulfate, Linum Usitatissimum Seed Extract, Sodium Hyaluronate, Mannitol, Phosphatidylcholine, Palmitoyl Pentapeptide-4, Copper Tripeptide-1, Ferulic Acid, Gold, Tocopherol, Tridecane, Asiaticoside, Propylene Carbonate, Glyceryl Caprylate, Cetyl Alcohol, Decyl Glucoside, P-Anisic Acid, Xanthan Gum, Tocopheryl Acetate, Sodium Chloride, Sodium Benzoate, Potassium Sorbate, Phenoxyethanol

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Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.

It is a:

Humectant, drawing moisture into the skin

Emollient, helping to soften skin

Solvent, dispersing and stabilizing formulas

Preservative booster, enhancing the antimicrobial activity of other preservatives

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Cetyl Alcohol is a fatty alcohol. Fatty Alcohols are most often used as an emollient or to thicken a product.

Its main roles are:

Though it has "alcohol" in the name, it is not related to denatured alcohol or ethyl alcohol.

The FDA allows products labeled "alcohol-free" to have fatty alcohols.

This ingredient may not be fungal acne safe. It is a primary fatty alcohol with a chain length above 12 carbons. A study from 2019 show Malassezia can feed on fatty alcohols in this range, so it may trigger fungal acne in those prone to it.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Potassium Sorbate is a preservative used to prevent yeast and mold in products. It is commonly found in both cosmetic and food products.

This ingredient comes from potassium salt derived from sorbic acid. Sorbic acid is a natural antibiotic and effective against fungus.

Both potassium sorbate and sorbic acid can be found in baked goods, cheeses, dried meats, dried fruit, ice cream, pickles, wine, yogurt, and more.

You'll often find this ingredient used with other preservatives.

Sodium Benzoate is a preservative. It's used in both cosmetic and food products to inhibit the growth of mold and bacteria. It is typically produced synthetically.

Both the US FDA and EU Health Committee have approved the use of sodium benzoate. In the US, levels of 0.1% (of the total product) are allowed.

Sodium benzoate works as a preservative by inhibiting the growth of bacteria inside of cells. It prevents the cell from fermenting a type of sugar using an enzyme called phosphofructokinase.

It is the salt of benzoic acid. Foods containing sodium benzoate include soda, salad dressings, condiments, fruit juices, wines, and snack foods.

Studies for using ascorbic acid and sodium benzoate in cosmetics are lacking, especially in skincare routines with multiple steps.

We always recommend speaking with a professional, such as a dermatologist, if you have any concerns.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Tocopheryl Acetate is a stable, shelf-friendly form of vitamin E.

Formulators love it because plain vitamin E oxidizes quickly once it hits air. This acetate version stays stable and resists going off, helping to extend a product's shelf life.

It's actually inactive on its own and works like a slow-release "storage" form; the enzymes in your skin called esterases gradually convert it into active vitamin E over time.

One in vivo study showed 5% of the acetate in the living layer of the epidermis converted to vitamin E after 5 days of application. This study also found the skin gained protection against UV damage even though the conversion was slow and small.

Once converted, vitamin E acts as a skin's main fat-soluble antioxidant that fights free radicals to protect skin from damage.

Topical vitamin E generally boosts the skin's photoprotection, and it reduced UV-damage in animal models.

This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.

Overall, it has a pretty solid safety profile and has been found to be non-irritating and non-comedogenic. Allergic reactions may happen but stay rare due to how widely the ingredient gets used.

The concentration will vary depending on the formula; industry data shows 0.1% in baby lotions, 3% in lipsticks, and 5% in foot powders. You can also find this ingredient at 100% in a pure vitamin E oil.

Most leave-on skincare keeps it at the lower end, often between 0.5-1%.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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