Skin science article
Paula's Choice Probiotic Nutrient Moisturizer Versus Youth To The People Adaptogen Deep Moisture Cream
Paula's Choice Probiotic Nutrient Moisturizer Versus Youth To The People Adaptogen Deep Moisture Cream This barrier-repair moisturizer is formulated around Lactobacillus Ferment and Bifida Ferment Lysate to strengthen the skin barrier and hydrate skin. This ca
Paula's Choice Probiotic Nutrient Moisturizer Versus Youth To The People Adaptogen Deep Moisture Cream
This barrier-repair moisturizer is formulated around Lactobacillus Ferment and Bifida Ferment Lysate to strengthen the skin barrier and hydrate skin.
This calming moisturizer is formulated around Niacinamide and Tremella Fuciformis Polysaccharide to calm redness and hydrate skin.
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Isoamyl Laurate
Glycerin
Butylene Glycol
Sodium Polyacrylate Starch
Cetyl Alcohol
Lauroyl Lysine
Lactobacillus/Rye Flour Ferment
Lactobacillus Ferment
Bifida Ferment Lysate
Glucomannan
Saccharomyces Lysate
Leuconostoc/Radish Root Ferment Filtrate
Glycine Soja Seed Extract
Camellia Sinensis Leaf Extract
Tetrahexyldecyl Ascorbate
Acetyl Hexapeptide-1
Palmitoyl Dipeptide-10
Ceramide Ng
Orbignya Oleifera Seed Oil
Palmitoyl Proline
Glycine
Serine
Threonine
Alanine
Valine
Arginine
Proline
Lysine Hcl
Rubus Idaeus Fruit Extract
Niacinamide
Adenosine
Lecithin
Phytic Acid
Yeast Extract
Faex
Tocopherol
Sodium PCA
Sodium Lactate
PCA
Magnesium Palmitoyl Glutamate
Sodium Palmitoyl Sarcosinate
Isopropyl Palmitate
Glutamic Acid
Betaine
Glyceryl Stearate
Hydroxyacetophenone
Sodium Acrylates Copolymer
Ceteth-20
Steareth-20
Polysorbate 20
PEG-75 Stearate
Caprylyl Glycol
Propylene Glycol
1,2-Hexanediol
Phenoxyethanol
Ethylhexylglycerin
Water, Isoamyl Laurate, Glycerin, Butylene Glycol, Sodium Polyacrylate Starch, Cetyl Alcohol, Lauroyl Lysine, Lactobacillus/Rye Flour Ferment, Lactobacillus Ferment, Bifida Ferment Lysate, Glucomannan, Saccharomyces Lysate, Leuconostoc/Radish Root Ferment Filtrate, Glycine Soja Seed Extract, Camellia Sinensis Leaf Extract, Tetrahexyldecyl Ascorbate, Acetyl Hexapeptide-1, Palmitoyl Dipeptide-10, Ceramide Ng, Orbignya Oleifera Seed Oil, Palmitoyl Proline, Glycine, Serine, Threonine, Alanine, Valine, Arginine, Proline, Lysine Hcl, Rubus Idaeus Fruit Extract, Niacinamide, Adenosine, Lecithin, Phytic Acid, Yeast Extract, Faex, Tocopherol, Sodium PCA, Sodium Lactate, PCA, Magnesium Palmitoyl Glutamate, Sodium Palmitoyl Sarcosinate, Isopropyl Palmitate, Glutamic Acid, Betaine, Glyceryl Stearate, Hydroxyacetophenone, Sodium Acrylates Copolymer, Ceteth-20, Steareth-20, Polysorbate 20, PEG-75 Stearate, Caprylyl Glycol, Propylene Glycol, 1,2-Hexanediol, Phenoxyethanol, Ethylhexylglycerin
Ethyl Oleate
Centaurea Cyanus Flower Water
Glyceryl Stearate Citrate
Behenyl Alcohol
Lauryl Laurate
Butyrospermum Parkii Butter
Ammonium Polyacryloyldimethyl Taurate
Inonotus Obliquus Extract
Tremella Fuciformis Polysaccharide
Acetyl Dipeptide-1 Cetyl Ester
Ganoderma Lucidum Extract
Linoleic Acid
Linolenic Acid
Oleic Acid
Sodium Hydroxide
Stearic Acid
Withania Somnifera Root Extract
Panthenol
Ceramide NP
C12-16 Alcohols
Hydrogenated Lecithin
Palmitic Acid
Simmondsia Chinensis Seed Oil
Squalane
Citric Acid
Coco-Betaine
Fructose
Helianthus Annuus Seed Oil
Propanediol
Xanthan Gum
Caramel
Benzyl Alcohol
Potassium Sorbate
Water, Glycerin, Ethyl Oleate, Centaurea Cyanus Flower Water, Niacinamide, Glyceryl Stearate Citrate, Behenyl Alcohol, Lauryl Laurate, Butyrospermum Parkii Butter, Ammonium Polyacryloyldimethyl Taurate, Inonotus Obliquus Extract, Tremella Fuciformis Polysaccharide, Acetyl Dipeptide-1 Cetyl Ester, Ganoderma Lucidum Extract, Linoleic Acid, Linolenic Acid, Oleic Acid, Phytic Acid, Sodium Hydroxide, Stearic Acid, Withania Somnifera Root Extract, Panthenol, Tocopherol, Ceramide NP, C12-16 Alcohols, Hydrogenated Lecithin, Palmitic Acid, Simmondsia Chinensis Seed Oil, Squalane, Arginine, Caprylyl Glycol, Citric Acid, Coco-Betaine, Ethylhexylglycerin, Fructose, Helianthus Annuus Seed Oil, Propanediol, Xanthan Gum, Caramel, Benzyl Alcohol, Phenoxyethanol, Potassium Sorbate
Reviews
Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Arginine is a semi-essential amino acid. This just means our bodies can product a bit on its own, but sometimes needs a little boost from food sources.
It is a part of your skin's natural moisturizing factor (NMF), or the water-loving molecules in your outermost layer of skin (stratum corneum) that keeps everything hydrated and happy.
Here's an interesting thing about Arginine: your skin converts it into urea through the Krebs-Henseleit urea cycle. Urea is one of the most effective humectants your skin naturally produces.
A clinical study showed applying 2.5% arginine hydrochloride to atopic dermatitis skin showed significant urea levels in the stratum corneum and improved moisture in just four weeks.
Arginine is also a precursor to nitric oxide; nitric oxide improves microcirculation and supports wound healing and collagen synthesis.
One study found that an amino acid complex containing Arginine reduced skin irritation, improved hydration, and accelerated skin repair in clinical / in-vivo studies.
Arginine itself is an amino acid and not a fatty acid, oil, or ester. On its own, it's not a direct food source for Malassezia, or the yeast that causes fungal acne.
Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.
Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.
Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).
Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:
The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.
Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.
Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Niacinamide is a multitasking form of vitamin B3 that strengthens the skin barrier, reduces pores and dark spots, regulates oil, and improves signs of aging.
And the best part? It's gentle and well-tolerated by most skin types, including sensitive and reactive skin.
You might have heard of "niacin flush", or the reddening of skin that causes itchiness. Niacinamide has not been found to cause this.
In very rare cases, some individuals may not be able to tolerate niacinamide at all or experience an allergic reaction to it.
If you are experiencing flaking, irritation, and dryness with this ingredient, be sure to double check all your products as this ingredient can be found in all categories of skincare.
When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.
When you apply niacinamide to your skin, your body converts it into nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme that is already found in your cells as "fuel" and powers countless biological processes.
In your skin, NAD helps repair cell damage, produce new healthy cells, support collagen production, strengthen the skin barrier, and fight environmental stressors (like UV and pollution).
Our natural NAD levels start to decline with age, leading to slower skin repair, visible aging, and a weaker skin barrier. By providing your skin niacinamide, you're recharging your skin's NAD levels. This leads to stronger, healthier, and younger looking skin.
Another name for vitamin B3 is nicotinamide. This vitamin is water-soluble and our bodies don't store it. We obtain Vitamin B3 from either food or skincare. Meat, fish, wheat, yeast, and leafy greens contain vitamin B3.
The type of niacinamide used in skincare is synthetically created.
Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).
It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.
On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.
Another perk of this ingredient is that it stays functional across a wide pH range (3-10).
You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.
Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.
Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.
Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.
Phytic Acid is a gentle AHA and antioxidant. AHAs are chemical exfoliants that help remove dead skin cells. Phytic Acid has a slight and mild exfoliating effect.
The chemical makeup makes it classified as an AHA, much like lactic acid.
In some cases, it is a chelating agent. Chelating agents help prevent metals from binding to water, helping to stabilize the ingredients in a product.
An interesting fact about phytic acid is that it is considered an antinutrient. People do not have the enzyme needed to properly breakdown and digest phytic acid. When ingested, phytic acid binds to minerals and prevents them from being absorbed.
Read more about some other popular AHA's here:
Tocopherol is a fat-soluble antioxidant known as Vitamin E.
You'll find this ingredient in the vast majority of skincare (for good reason). It works to neutralize free radicals, or unstable molecules generated by UV exposure, pollution, and other environmental stressors, before they can cause oxidative damage to your skin cells.
Topically applied tocopherol has been shown to protect against UV damage by ramping up the skin's own natural defense enzymes.
It also acts as a skin conditioning agent; some studies show that regular topical use can improve the skin's water-binding capacity over 2-4 weeks.
This ingredient is especially loved for being a team player. When combined with Vitamin C, the photoprotective effect of both ingredients roughly doubles and the combo also helps reduce UV-induced DNA damage.
This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.
In formulations, it also serves as a stabilizer that helps protect other oxidation-prone ingredients from degrading.
Concentrations usually range from 0.1-1% in most leave-on products.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!