Peptide Skincare & BeautySkin science and ingredient guides

Skin science article

Revision Skincare Youthfull Lip Replenisher Versus PCA Skin Hyaluronic Acid Lip Booster

Revision Skincare Youthfull Lip Replenisher Versus PCA Skin Hyaluronic Acid Lip Booster This anti-aging lip moisturizer is formulated around Sodium Hyaluronate and Palmitoyl Tripeptide-1 to soften the look of wrinkles and hydrate lips. What's inside Key Ingred

Revision Skincare Youthfull Lip Replenisher Versus PCA Skin Hyaluronic Acid Lip Booster

This anti-aging lip moisturizer is formulated around Sodium Hyaluronate and Palmitoyl Tripeptide-1 to soften the look of wrinkles and hydrate lips.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Hydrogenated Polyisobutene

Jojoba Esters

Phenyl Trimethicone

Tribehenin

Helianthus Annuus Seed Oil Unsaponifiables

Ethylhexyl Palmitate

Butyrospermum Parkii Butter

Butyrospermum Parkii Butter Unsaponifiables

Sodium Hyaluronate

Sucrose Cocoate

Tetrahexyldecyl Ascorbate

Tocopheryl Acetate

Camellia Sinensis Leaf Extract

Palmitoyl Tripeptide-1

Palmitoyl Tripeptide-38

Dipalmitoyl Hydroxyproline

Portulaca Pilosa Extract

Caprylic/Capric Triglyceride

Butylene Glycol

Cetearyl Ethylhexanoate

Sorbitan Isostearate

Silica Dimethyl Silylate

Glyceryl Caprylate

Mentha Arvensis Leaf Oil

Hydrogenated Polyisobutene, Jojoba Esters, Phenyl Trimethicone, Tribehenin, Helianthus Annuus Seed Oil Unsaponifiables, Ethylhexyl Palmitate, Butyrospermum Parkii Butter, Butyrospermum Parkii Butter Unsaponifiables, Sodium Hyaluronate, Sucrose Cocoate, Tetrahexyldecyl Ascorbate, Tocopheryl Acetate, Camellia Sinensis Leaf Extract, Palmitoyl Tripeptide-1, Palmitoyl Tripeptide-38, Dipalmitoyl Hydroxyproline, Portulaca Pilosa Extract, Caprylic/Capric Triglyceride, Butylene Glycol, Cetearyl Ethylhexanoate, Sorbitan Isostearate, Silica Dimethyl Silylate, Glyceryl Caprylate, Mentha Arvensis Leaf Oil

Petrolatum

Ethylene/Propylene/Styrene Copolymer

Beeswax

Tocopherol

Aroma

Ricinus Communis Seed Oil

Sodium Saccharin

Butylene/Ethylene/Styrene Copolymer

BHT

Trihydroxystearin

Amorphophallus Konjac Root Powder

Petrolatum, Hydrogenated Polyisobutene, Ethylene/Propylene/Styrene Copolymer, Beeswax, Ethylhexyl Palmitate, Cetearyl Ethylhexanoate, Tocopherol, Tribehenin, Aroma, Ricinus Communis Seed Oil, Sorbitan Isostearate, Sodium Saccharin, Portulaca Pilosa Extract, Butylene/Ethylene/Styrene Copolymer, BHT, Trihydroxystearin, Sucrose Cocoate, Sodium Hyaluronate, Palmitoyl Tripeptide-1, Palmitoyl Tripeptide-38, Amorphophallus Konjac Root Powder

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Cetearyl Ethylhexanoate is derived from cetearyl alcohol and sorbic acid.

It is an emollient and helps hydrate the skin. Emollients form a barrier on the skin to prevent water from escaping.

Ethylhexyl Palmitate, also known as octyl palmitate, is created from 2-ethylhexyl alcohol and palmitic acid.

In cosmetics, it plays many roles:

One thing worth noting: a controlled study found this ingredient applied under occlusion to acne-prone subjects increased microcomedones. Just keep in mind this was under occlusive conditions and don't reflect how most products are used day-to-day.

For most people, this is a well-tolerated and lightweight ingredient.

This ingredient may not be fungal acne safe because it is an ester of palmitic acid, a C16 fatty acid that falls within the C11-24 range that Malassezia can metabolize.

Hydrogenated Polyisobutene is a synthetic polymer. Polymers are compounds with high molecular weight. Hydrogenated Polyisobutene is an emollient and texture enhancer.

In one study, Hydrogenated Polyisobutene showed better skin hydration levels than Caprylic/Capric Triglyceride. As an emollient, it helps keep your skin soft and hydrated by trapping moisture in.

Hydrogenated Polyisobutene is often used as a mineral oil replacement.

Palmitoyl Tripeptide-1 (aka Pal-GHK) is a synthetic signal peptide made of three amino acids attached to palmitic acid.

That fatty acid attachment is the key: it boosts the peptide's ability to penetrate the skin barrier. This puts it closer to the dermal cells where it can actually make a difference.

Once there, it acts as a matrikine, a signaling peptide that prompts fibroblasts to produce more collagen, fibronectin, and hyaluronic acid.

In vitro studies show it can boost collagen production in skin cells even when UV-damaged skin samples were treated with it at a tiny concentration (it almost fully restored dermal collagen at 5ppm). It achieved this at 100x lower concentration than retinoic acid, which needed 500 ppm to do the same thing.

Human clinical data is promising, but modest:

A study of 23 female volunteers found a small but statistically significant increase (~4%) in skin thickness after treatment at 4 ppm.

A separate small trial of 15 women showed statistically significant reductions in wrinkle length, depth, and skin roughness after applying it twice daily for four weeks.

You'll likely see Pal-GHK paired with Palmitoyl Tetrapeptide-7 as part of the Matrixyl 3000 complex.

Fungal acne note: Usually a palmitic acid component can feed Malassezia in unbound form, but here is is covalently bonded to the peptide. This means it is very difficult for Malassezia to access, and therefore very unlikely to cause fungal acne.

This synthetic, signal peptide has unique skin conditioning properties in that is a matrikine-mimetic compound.

First of all, Palmitoyl Tripeptide-38 is a signal peptide; signal peptides tell the body to create more collagen.

What is a matrikine-mimetic compound?

This peptide has the ability to mimic matrikines in skin. Our skin created matrikines by breaking down matrix proteins into peptides.

Matrikines play a role in:

Though further research is needed, this ingredient seems pretty promising. In one study, women over the age of 40 with visible photoaging used a vitamin C serum with this ingredient for 56 days (15% ascorbid acid, 5 ppm palmitoyl tripeptide‐38). The results found improvement in skin roughness and skin tone.

This peptide is also part of the famous Matrixyl synthe’6, a blend of ingredients that also includes glycerin, water, and hydroxypropyl cyclodextrin.

We don't have a description for Portulaca Pilosa Extract yet.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Sorbitan Isostearate is an emulsifer. It is created from isostearic acid and sorbitol.

As an emulsifier, it keeps the water and oil ingredients from separating. This keeps formulas stable and smooth.

In a 24 hour occlusive patch test on 56 subjects, 10% sorbitan isostearate was completely non-irritating. Most formulas use less than 10%.

Because it's a fatty acid ester, it may not be fungal acne safe since the Malassezia yeast can utilize it as a nutrient source.

Sucrose cocoate is a mild multitasking ingredient made by esterifying sugar with the fatty acids of coconut oil.

It functions as a surfactant, emulsifier, and skin-conditioning ingredient all in one.

Typical use concentrations range from:

This ingredient is well-tolerated across skin types and has been classified safe for use in cosmetic products by the Cosmetic Ingredient Review Expert Panel. It's even considered gentle enough for use in baby care products like shampoos and lotions.

Fungal acne note: Sucrose cocoate is a fatty acid ester derived from coconut oil that contains fatty acids in the C12-18 range. This is the range that Malassezia can metabolize, meaning this ingredient may not be fungal acne safe.

Tribehenin is the triglyceride of glycerin and behenic acid. It is an emollient that helps soften and condition skin.

Safety-wise, this is a well-vetted ingredient. Repeated-insult patch tests of 0.38% tribehenin did not trigger sensitization.

This ingredient may not be fungal acne safe because behenic acid falls into the chain-length range that Malassezia yeasts can feed on.

Similar Comparisons

The reference edit

Ingredients, questions
& further reading.

Connected source records selected through this article’s public topic index.

01

Formula cabinet

Ingredients & structured notes

Ingredient index

Ingredients Explained

  1. 01These ingredients are found in both products.
  2. 02Ingredients higher up in an ingredient list are typically present in a larger amount.
  3. 03Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
  4. 04Topically, glycerin does several things at once:
  5. 05Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
  6. 06Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
  7. 07This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
  8. 08Just know very high concentrations (>40%) can feel tacky in low humidity.
  9. 09Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
  10. 10Panthenol is a common ingredient that helps hydrate and soothe the skin. It is found naturally in our skin and hair.
  11. 11There are two forms of panthenol: D and L.
  12. 12D-panthenol is also known as dexpanthenol. Most cosmetics use dexpanthenol or a mixture of D and L-panthenol.
  13. 13Panthenol is famous due to its ability to go deeper into the skin's layers. Using this ingredient has numerous pros (and no cons):
  14. 14Like hyaluronic acid, panthenol is a humectant. Humectants are able to bind and hold large amounts of water to keep skin hydrated.
  15. 15This ingredient works well for wound healing. It works by increasing tissue in the wound and helps close open wounds.
  16. 16Once oxidized, panthenol converts to pantothenic acid. Panthothenic acid is found in all living cells.
  17. 17This ingredient is also referred to as pro-vitamin B5.
  18. 18Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).
  19. 19It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.
  20. 20On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.
Source · skinsort.com
02

Product index

Related product references

Product

PCA Skin Daily Defense Mist

PCA Skin Daily Defense Mist PCA Skin Daily Defense Mist ingredients explained: Water, Aloe Barbadensis Leaf Juice, Glycerin, Propanediol, Phenoxyethanol, Caprylyl/Capryl Glucoside, Marrubiu…

Source: incidecoder.comView reference →

Product

PCA Skin Smoothing Toner

PCA Skin Smoothing Toner PCA Skin Smoothing Toner ingredients explained: Water/Aqua/Eau, Lactic Acid, Citric Acid, Glycerin, Aloe Barbadensis Leaf Juice, Hydrastis Canadensis (Goldenseal) E…

Source: incidecoder.comView reference →
03

Comparison edit

Read side by side