SkinBetter Science Interufse Intensive Treatment Lines Versus SkinCeuticals P-Tiox Wrinkle Modulating Peptide Serum

SkinBetter Science Interufse Intensive Treatment Lines Versus SkinCeuticals P-Tiox Wrinkle Modulating Peptide Serum

This anti-aging serum is formulated around Acetyl Glucosamine and Tetrahexyldecyl Ascorbate to soften the look of wrinkles and refine skin texture.

This anti-aging serum is formulated around Dipeptide Diaminobutyroyl Benzylamide Diacetate and Acetyl Hexapeptide-8 to soften the look of wrinkles and refine skin texture.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

C12-15 Alkyl Benzoate

Glycerin

PEG-16 Macadamia Glycerides

Dimethicone

Acetyl Glucosamine

Alcohol Denat.

Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer

Sodium Citrate

Tetrahexyldecyl Ascorbate

Sodium Hyaluronate

Glycine

Hydroxyproline

Proline

Acetyl Hexapeptide-8

Hexapeptide-48 Hcl

Palmitoyl Tripeptide-1

Palmitoyl Tetrapeptide-7

Dipeptide Diaminobutyroyl Benzylamide Diacetate

Sodium Acetylated Hyaluronate

Pisum Sativum Extract

Glycine Soja Seed Extract

Glucosamine Hcl

Ophiopogon Japonicus Root Extract

Bambusa Vulgaris Leaf/Stem Extract

Hydrolyzed Lupine Protein

Oleic Acid

Sorbitan Isostearate

C18-36 Acid Glycol Ester

PEG-7 Trimethylolpropane Coconut Ether

Sorbitan Laurate

Hexylene Glycol

Polyisobutene

C18-36 Acid Triglyceride

Carbomer

Acrylates Copolymer

Citric Acid

Caprylyl Glycol

Ethylhexylglycerin

Potassium Sorbate

Phenoxyethanol

Water, C12-15 Alkyl Benzoate, Glycerin, PEG-16 Macadamia Glycerides, Dimethicone, Acetyl Glucosamine, Alcohol Denat., Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Sodium Citrate, Tetrahexyldecyl Ascorbate, Sodium Hyaluronate, Glycine, Hydroxyproline, Proline, Acetyl Hexapeptide-8, Hexapeptide-48 Hcl, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Sodium Acetylated Hyaluronate, Pisum Sativum Extract, Glycine Soja Seed Extract, Glucosamine Hcl, Ophiopogon Japonicus Root Extract, Bambusa Vulgaris Leaf/Stem Extract, Hydrolyzed Lupine Protein, Oleic Acid, Sorbitan Isostearate, C18-36 Acid Glycol Ester, PEG-7 Trimethylolpropane Coconut Ether, Sorbitan Laurate, Hexylene Glycol, Polyisobutene, C18-36 Acid Triglyceride, Carbomer, Acrylates Copolymer, Citric Acid, Caprylyl Glycol, Ethylhexylglycerin, Potassium Sorbate, Phenoxyethanol

Niacinamide

Gluconolactone

Butylene Glycol

PEG/PPG/Polybutylene Glycol-8/5/3 Glycerin

Pentylene Glycol

Methyl Gluceth-20

Potassium Hydroxide

Hydroxyethylcellulose

Salicylic Acid

Chlorphenesin

Phytic Acid

Adenosine

Sodium Benzoate

Laminaria Digitata Extract

Water, Niacinamide, Gluconolactone, Butylene Glycol, PEG/PPG/Polybutylene Glycol-8/5/3 Glycerin, Alcohol Denat., Pentylene Glycol, Methyl Gluceth-20, Glycerin, Potassium Hydroxide, Hydroxyethylcellulose, Salicylic Acid, Chlorphenesin, Phytic Acid, Adenosine, Sodium Benzoate, Laminaria Digitata Extract, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Acetyl Hexapeptide-8

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Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Acetyl Hexapeptide-8 (also known as Argireline) is a synthetic hexapeptide that is often called a "topical Botox alternative".

It works by mimicking how Botox relaxes muscles; it interferes with the signaling process that tells your facial muscles to contract. This can help soften expression lines like forehead wrinkles or crow's feet over time.

The comparison to Botox does have limits because the molecule is water-loving and relatively large.

Acetyl Hexapeptide-8 has a hard time absorbing deeply enough through the skin's outer barrier to actually reach the muscles.

So whether it truly works the way Botox does at a biological level is still up for debate, but early clinical outcomes are fairly encouraging.

A 12 week human study of a multi-ingredient regimen containing this ingredient saw:

While some studies have observed improvements in wrinkle appearance, it is important to note that more consistent results are seen in multi-ingredient formulations (vs just Acetyl Hexapeptide-8 alone).

Some research studies also used higher concentrations (up to 10%) while this ingredient is usually found in concentrations up to 0.005% in leave-on formulations.

Alcohol Denat. is an alcohol with a denaturant property. It is created by mixing ethanol with other additives.

The "denat" part just means "denatured"; common denaturants include Denatonium Benzoate, t-butyl alcohol, and Diethyl Phthalate. This step makes the alcohol undrinkable (and lets brand skip taxes related to beverage alcohol).

This ingredient gets a bad rep because it is irritating and drying due to its astringent property. Astringents draw out natural oils in tissue to constrict pores and dry out your skin.

However, alcohol denat. is not all that bad.

Due to its low molecular weight, alcohol denat. tends to evaporate quickly. One study on pig skin found half of applied alcohol evaporated in 10 seconds and less than 3% stayed on skin.

This also helps other ingredients become better absorbed upon application.

Studies are conflicted about whether this ingredient causes skin dehydration. One study from 2005 found adding emollients to propanol-based sanitizer decreased skin dryness and irritation. Another study found irritation only occurs if your skin is already damaged.

Small amounts of alcohol are generally tolerated by oily skin or people who live in humid environments.

The rule of thumb is this ingredient will probably not affect your skin much if it is near the end of an ingredients list.

One thing to note: People with ALDH2 (aldehyde dehydrogenase 2) deficiency may experience skin irritation from continued alcohol use. About 8% of the world's population have this deficiency.

The Cosmetic Ingredient Review Expert Panel has determined denatured alcohols to be safe for use in concentrations between 0.05% and 12% (depending on which denaturant is used).

Also...

This ingredient has antimicrobial and solvent properties.

The antimicrobial property helps preserve products and increase their shelf life. As a solvent, it helps dissolve other ingredients.

Look for formulas that contain glycerin, hyaluronic acid, or panthenol if you want to offset any drying effect.

This ingredient will trip away your skin's natural oils/lipids that help it lock in moisture. This can worsen dryness, trigger eczema flare-ups, and aggravate rosacea.

Be sure to patch test any product with this ingredient if you have dry or sensitive skin, eczema, or rosacea.

This small molecule peptide has similar benefits to Argireline, the "botox" peptide.

According to the manufacturer, this peptide mimics snake venom to freeze muscles. This prevents muscle movement and contractions to prohibit the formation of fine lines and wrinkles.

While this seems promising, research is lacking in proving this ingredient to be as effective as botox.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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