StriVectin SD Advanced ™ PLUS Intensive Moisturizer For Wrinkles & Stretch Marks Versus Le Mieux Collagen Peptide Serum

StriVectin SD Advanced ™ PLUS Intensive Moisturizer For Wrinkles & Stretch Marks Versus Le Mieux Collagen Peptide Serum

This anti-aging moisturizer is formulated around Palmitoyl Tripeptide-38 and Copper Tripeptide-1 to soften the look of wrinkles and refine skin texture.

This anti-aging serum is formulated around Palmitoyl Tripeptide-1 and Palmitoyl Tetrapeptide-7 to soften the look of wrinkles and refine skin texture.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Glycerin

Pentaerythrityl Tetraisostearate

Trimethylolpropane Tricaprylate/Tricaprate

Neopentyl Glycol Diheptanoate

Propanediol

Myristyl Nicotinate

Cetearyl Alcohol

Butylene Glycol

Bis-Stearyl Dimethicone

Glyceryl Stearate

Theobroma Grandiflorum Seed Butter

Dimethicone

Sorbitan Stearate

Stearoxymethicone/Dimethicone Copolymer

1,2-Hexanediol

Palmitoyl Tripeptide-38

Oryza Sativa Bran Extract

Palmitoyl Tetrapeptide-7

Astrocaryum Murumuru Seed Butter

Palmitoyl Tripeptide-1

Copper Tripeptide-1

Saccharide Isomerate

Panthenol

Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer

PEG-40 Stearate

Astrocaryum Vulgare Kernel Oil

Polysilicone-11

Butyrospermum Parkii Butter

Ceteareth-20

Bisabolol

Caprylhydroxamic Acid

Nicotiana Benthamiana Hexapeptide-40 Sh-Oligopeptide-1

Phaseolus Lunatus Seed Extract

Aloe Barbadensis Leaf Juice

Bacillus/Sea Salt Ferment Filtrate

Zingiber Officinale Root Extract

Rosmarinus Officinalis Leaf Extract

Polyglyceryl-4 Diisostearate/Polyhydroxystearate/Sebacate

Pentaclethra Macroloba Seed Oil/Behenic Acid/Aminopropanediol Amides/Esters

Helianthus Annuus Extract

Hydrolyzed Hyaluronic Acid

Evodia Rutaecarpa Fruit Extract

Sodium Hyaluronate Crosspolymer

Nymphaea Alba Flower Extract

Methylglucoside Phosphate

Cetyl Hydroxyethylcellulose

Adenosine

Isohexadecane

Sorbitan Isostearate

Hydroxypropyl Cyclodextrin

Copper Lysinate/Prolinate

Aminomethyl Propanol

Dicaprylyl Ether

Dipotassium Phosphate

Ethylhexyl Stearate

Sodium Isostearate

Polysorbate 60

Resveratrol

Xanthan Gum

Disodium EDTA

Parfum

Lactic Acid

Mica

Rutin

Tocopherol

Sodium Citrate

Citric Acid

CI 77891

CI 77491

Water, Glycerin, Pentaerythrityl Tetraisostearate, Trimethylolpropane Tricaprylate/Tricaprate, Neopentyl Glycol Diheptanoate, Propanediol, Myristyl Nicotinate, Cetearyl Alcohol, Butylene Glycol, Bis-Stearyl Dimethicone, Glyceryl Stearate, Theobroma Grandiflorum Seed Butter, Dimethicone, Sorbitan Stearate, Stearoxymethicone/Dimethicone Copolymer, 1,2-Hexanediol, Palmitoyl Tripeptide-38, Oryza Sativa Bran Extract, Palmitoyl Tetrapeptide-7, Astrocaryum Murumuru Seed Butter, Palmitoyl Tripeptide-1, Copper Tripeptide-1, Saccharide Isomerate, Panthenol, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, PEG-40 Stearate, Astrocaryum Vulgare Kernel Oil, Polysilicone-11, Butyrospermum Parkii Butter, Ceteareth-20, Bisabolol, Caprylhydroxamic Acid, Nicotiana Benthamiana Hexapeptide-40 Sh-Oligopeptide-1, Phaseolus Lunatus Seed Extract, Aloe Barbadensis Leaf Juice, Bacillus/Sea Salt Ferment Filtrate, Zingiber Officinale Root Extract, Rosmarinus Officinalis Leaf Extract, Polyglyceryl-4 Diisostearate/Polyhydroxystearate/Sebacate, Pentaclethra Macroloba Seed Oil/Behenic Acid/Aminopropanediol Amides/Esters, Helianthus Annuus Extract, Hydrolyzed Hyaluronic Acid, Evodia Rutaecarpa Fruit Extract, Sodium Hyaluronate Crosspolymer, Nymphaea Alba Flower Extract, Methylglucoside Phosphate, Cetyl Hydroxyethylcellulose, Adenosine, Isohexadecane, Sorbitan Isostearate, Hydroxypropyl Cyclodextrin, Copper Lysinate/Prolinate, Aminomethyl Propanol, Dicaprylyl Ether, Dipotassium Phosphate, Ethylhexyl Stearate, Sodium Isostearate, Polysorbate 60, Resveratrol, Xanthan Gum, Disodium EDTA, Parfum, Lactic Acid, Mica, Rutin, Tocopherol, Sodium Citrate, Citric Acid, CI 77891, CI 77491

Hyaluronic Acid

Acetyl Tetrapeptide-2

Palmitoyl Pentapeptide-4

Palmitoyl Tripeptide-5

Acetyl Octapeptide-3

Oryza Sativa Bran Water

Epigallocatechin Gallatyl Glucoside

Camellia Sinensis Leaf Extract

Hydrolyzed Avocado Protein

Glycine Soja Seed Extract

Teprenone

Caprylic/Capric Triglyceride

Ceramide Ns

Ceramide NP

Tocotrienols

Brassica Campestris Sterols

Sodium Palmitoyl Proline

Malus Domestica Fruit Cell Culture Extract

Dipalmitoyl Hydroxyproline

Sodium Carboxymethyl Beta-Glucan

Superoxide Dismutase

Glucosamine Hcl

Laminaria Digitata Extract

Saccharomyces Cerevisiae Extract

Sodium PCA

Enteromorpha Compressa Extract

Urea

Retinyl Palmitate

Isomalt

Caprylyl Glycol

Ethylhexylglycerin

Undecylenoyl Glycine

Capryloyl Glycine

Hyaluronic Acid, Acetyl Tetrapeptide-2, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Palmitoyl Pentapeptide-4, Palmitoyl Tripeptide-5, Acetyl Octapeptide-3, Oryza Sativa Bran Water, Epigallocatechin Gallatyl Glucoside, Camellia Sinensis Leaf Extract, Hydrolyzed Avocado Protein, Glycine Soja Seed Extract, Teprenone, Caprylic/Capric Triglyceride, Ceramide Ns, Ceramide NP, Tocotrienols, Brassica Campestris Sterols, Butyrospermum Parkii Butter, Sodium Palmitoyl Proline, Nymphaea Alba Flower Extract, Malus Domestica Fruit Cell Culture Extract, Dipalmitoyl Hydroxyproline, Sodium Carboxymethyl Beta-Glucan, Superoxide Dismutase, Glucosamine Hcl, Laminaria Digitata Extract, Saccharomyces Cerevisiae Extract, Sodium PCA, Enteromorpha Compressa Extract, Urea, Retinyl Palmitate, Isomalt, Caprylyl Glycol, Ethylhexylglycerin, Undecylenoyl Glycine, Capryloyl Glycine

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

This ingredient is also known as shea butter. It is a plant-derived extract from the nuts of the Africa shea tree and one of the most well-studied emollients.

Because it has a high concentration of fatty acids (primarily oleic, stearic, and linoleic) it is able to form a protective barrier on the skin's surface. This helps seal in moisture and prevents transepidermal water loss (TEWL).

In vitro research found an increase in skin hydration by 58% and a decrease in TEWL by 37.8% after 24 hours of applying this ingredient (pretty impressive for a single ingredient!).

Besides hydration, shea butter also contains triterpenes that have anti-inflammatory potential. In particule, lupeol cinnamate has shown the highest anti-inflammatory activity in vivo.

Shea butter also contains vitamins A and E which may contribute to antioxidant activity.

While Shea Butter has an SPF rating of about 3-4, it is not a sunscreen replacement.

This ingredient may not be fungal acne safe because its fatty acids fall within the C11-C24 range that the Malassezia yeast can metabolize.

This ingredient is also known as white water lily extract and used in skincare as an antioxidant and skin conditioning ingredient.

It's rich in polyphenols and flavonoids that help calm irritation and protect skin from environmental damage.

Studies show it can also support wound healing and even out skin tone/radiance over time.

Its dermatological benefits include anti-aging, anti-inflammatory, antibacterial, and skin-brightening effects. A cream with 3% extract meaningfully reduced inflammation markers on skin and a separate wound-healing study used 5% concentrations.

At this time, there's no meaningful documentation of it being a common contact allergen in patch-test literature, but (as with any plant extract), individual sensitivity is always possible.

Palmitoyl Tetrapeptide-7 (formerly Palmitoyl Tetrapeptide-3) is a synthetic peptide. Its main job is to fight what researchers call "inflammaging".

"Inflammaging" is the slow, low-grade chronic inflammation that quietly breaks down collagen as we age.

This ingredient calms down a specific inflammation signal in your skin cells (called IL-6). When left unchecked, this signal triggers enzymes that break down collagen and elastin.

Clinical testing showed statistically significant improvements in:

Studies also found the more of this ingredient used, the more your skin produces Collagen I, fibronectin, and hyaluronic acid.

You'll likely see this ingredient paired with Palmitoyl Tripeptide-1 in the well-known Matrixyl 3000 complex for enhanced anti-aging effects.

A 3% concentration applied twice daily for two months showed meaningful skin rejuvenation results in clinical panels.

Fungal acne note: Usually a palmitic acid component can feed Malassezia in unbound form, but here is is covalently bonded to the peptide. This means it is very difficult for Malassezia to access, and therefore very unlikely to cause fungal acne.

Palmitoyl Tripeptide-1 (aka Pal-GHK) is a synthetic signal peptide made of three amino acids attached to palmitic acid.

That fatty acid attachment is the key: it boosts the peptide's ability to penetrate the skin barrier. This puts it closer to the dermal cells where it can actually make a difference.

Once there, it acts as a matrikine, a signaling peptide that prompts fibroblasts to produce more collagen, fibronectin, and hyaluronic acid.

In vitro studies show it can boost collagen production in skin cells even when UV-damaged skin samples were treated with it at a tiny concentration (it almost fully restored dermal collagen at 5ppm). It achieved this at 100x lower concentration than retinoic acid, which needed 500 ppm to do the same thing.

Human clinical data is promising, but modest:

A study of 23 female volunteers found a small but statistically significant increase (~4%) in skin thickness after treatment at 4 ppm.

A separate small trial of 15 women showed statistically significant reductions in wrinkle length, depth, and skin roughness after applying it twice daily for four weeks.

You'll likely see Pal-GHK paired with Palmitoyl Tetrapeptide-7 as part of the Matrixyl 3000 complex.

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