Ingredient or product comparison
GHK-Cu Cosmetic Dosage for Collagen Boost: Protocol Comparison
Subcutaneous Injection 1–3 mg/kg bodyweight daily ~80% systemic absorption Twice daily (every 12 hours) Achieved within 30–60 minutes post-injection Preferred for systemic collagen remodeling. Highest bioavailability, measurable plasma levels, consistent tissu
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- Subcutaneous Injection
- 1–3 mg/kg bodyweight daily
- ~80% systemic absorption
- Twice daily (every 12 hours)
- Achieved within 30–60 minutes post-injection
- Preferred for systemic collagen remodeling. Highest bioavailability, measurable plasma levels, consistent tissue exposure
- Topical Application
- 0.05–0.1% (500–1000 μg/mL)
- 15–20% dermal penetration
- Twice daily to clean skin
- Dermal concentration peaks 2–4 hours post-application
- Effective for localized photoaging or scar remodeling. Lower systemic exposure, site-specific targeting
- Oral Administration
- Not recommended
- <5% (degraded in GI tract)
- N/A
- Negligible dermal tissue levels
- Avoid. GHK-Cu is cleaved by gastric peptidases before systemic absorption; oral dosing does not produce therapeutic collagen synthesis
- Microneedling + Topical
- 0.1–0.2% applied post-procedure
- 40–50% (barrier disruption increases penetration)
- Single application per microneedling session (every 4–6 weeks)
- Immediate dermal exposure via microchannels
- High-efficiency delivery for scar revision and textural remodeling. Combines mechanical stimulation with peptide deposition