CeraVe Moisturizing Cream Versus The Derma Co Skin Renew Barrier Repair Peptide Moisturizer

CeraVe Moisturizing Cream Versus The Derma Co Skin Renew Barrier Repair Peptide Moisturizer

This barrier-repair moisturizer is formulated around Ceramide NP and Ceramide AP to strengthen the skin barrier and hydrate skin.

This barrier-repair moisturizer is formulated around Niacinamide and Ceramide NP to strengthen the skin barrier and soften the look of wrinkles.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Glycerin

Cetearyl Alcohol

Caprylic/Capric Triglyceride

Cetyl Alcohol

Ceteareth-20

Petrolatum

Potassium Phosphate

Ceramide NP

Ceramide AP

Ceramide EOP

Carbomer

Dimethicone

Behentrimonium Methosulfate

Sodium Lauroyl Lactylate

Sodium Hyaluronate

Cholesterol

Phenoxyethanol

Disodium EDTA

Dipotassium Phosphate

Tocopherol

Phytosphingosine

Xanthan Gum

Ethylhexylglycerin

Water, Glycerin, Cetearyl Alcohol, Caprylic/Capric Triglyceride, Cetyl Alcohol, Ceteareth-20, Petrolatum, Potassium Phosphate, Ceramide NP, Ceramide AP, Ceramide EOP, Carbomer, Dimethicone, Behentrimonium Methosulfate, Sodium Lauroyl Lactylate, Sodium Hyaluronate, Cholesterol, Phenoxyethanol, Disodium EDTA, Dipotassium Phosphate, Tocopherol, Phytosphingosine, Xanthan Gum, Ethylhexylglycerin

Propanediol

Coco-Caprylate/Caprate

Niacinamide

Betaine

Cyclopentasiloxane

Neopentyl Glycol Diheptanoate

Isododecane

Squalane

3-O-Ethyl Ascorbic Acid

PEG-7 Glyceryl Cocoate

Glyceryl Stearate

Palmitoyl Tripeptide-5

Polyacrylate-13

Polyisobutene

Polysorbate 20

Glyceryl Stearate Citrate

Centella Asiatica Extract

Xylitylglucoside

Anhydroxylitol

Xylitol

Allantoin

Acrylates/C10-30 Alkyl Acrylate Crosspolymer

Triethanolamine

Sodium Gluconate

Water, Propanediol, Coco-Caprylate/Caprate, Cetearyl Alcohol, Niacinamide, Betaine, Cyclopentasiloxane, Neopentyl Glycol Diheptanoate, Isododecane, Squalane, 3-O-Ethyl Ascorbic Acid, Ceramide NP, PEG-7 Glyceryl Cocoate, Phenoxyethanol, Ethylhexylglycerin, Glyceryl Stearate, Palmitoyl Tripeptide-5, Polyacrylate-13, Polyisobutene, Polysorbate 20, Glyceryl Stearate Citrate, Centella Asiatica Extract, Xylitylglucoside, Anhydroxylitol, Xylitol, Sodium Hyaluronate, Allantoin, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Triethanolamine, Sodium Gluconate

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Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Ceramide NP (formerly known as Ceramide 3) is one of the skin's naturally occurring lipids.

Since ceramides are the major lipid components of the skin, they are crucial for maintaining skin barrier and hydration. Ceramide NP most closely mirrors the dominant kind in human skin amongst ceramide subtypes.

This ceramide works by slotting into gaps within the stratum corneum's lipid matrix to limit trans-epidermal water loss (TEWL) and shield the skin against external irritants.

A study with 312 patients found that using a ceramide-containing routine for 4 weeks reduced the severity of atopic dermatitis by over 61%.

Another clinical study in subjects aged 60 and older found that a ceramide body wash and moisturizer improved skin dryness and itchy skin in 15 days.

Overall, ceramides are considered non-irritating and safety tests have found little to no observable adverse effects from using this ingredient.

Ceramide NP is usually sourced from plants (like soybean or rice bran), or produced synthetically.

Cetearyl alcohol is a waxy mixture of two fatty alcohols: cetyl alcohol and stearyl alcohol. It is an emollient and emulsifier.

Despite having "alcohol" in its name, it has nothing to do with drying solvent alcohols; the FDA also allows "alcohol-free" products to contain fatty alcohols like this ingredient.

It plays several roles in a formula:

Typical use levels for this ingredient sit around 1-10% and the Cosmetic Ingredient Review Expert Panel has affirmed safety at concentrations up to 25% in leave-on products.

Multiple assessments have found it to be non-irritating and non-sensitizing to most people.

However, there have been some cases of allergic contact dermatitis in patients with chronically compromised skin barriers.

Cetearyl alcohol has a comedogenic rating of 2 and irritancy rating of 1. Both of these numbers come from the 1989 study that used rabbit ears; a "2" means mildly comedogenic and a "1" means low irritancy.

Here's the catch: rabbit skin is more sensitive than human skin and throws a lot of false positives. A 1996 reappraisal found that ingredients rated 1-2 in the rabbit ear tests are generally safe for humans.

Remember comedogenic ratings are unable to assess the entire formula of a product or how it will react on your skin. Just be sure to patch test if you are unsure about certain ingredients.

This ingredient is not fungal acne safe. Cetearyl alcohol is a fatty alcohol with chain lengths that fall within the range that Malassezia can metabolize.

A 2019 study has also observed Malassezia growth in the presence of this ingredient, confirming it to be not-fungal acne safe.

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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